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[User Story] Add MSI analysis #1443

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khurrammaqbool opened this issue Jun 5, 2024 · 3 comments · Fixed by #1444, #1454 or #1459 · May be fixed by #1463
Open
3 tasks

[User Story] Add MSI analysis #1443

khurrammaqbool opened this issue Jun 5, 2024 · 3 comments · Fixed by #1444, #1454 or #1459 · May be fixed by #1463
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User-Story A User-Story describing new functionality
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@khurrammaqbool
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khurrammaqbool commented Jun 5, 2024

Need

MSI analysis was requested to be included to the workflow in #972

Suggested approach

Add MSIsensor-pro. See https://github.com/xjtu-omics/msisensor-pro/wiki and Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, et al. MSIsensor-pro: fast, accurate, and matched-normal-sample-free detection of microsatellite instability. Genomics Proteomics Bioinformatics 2020,18(1). PDF for more details.

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System requirements assessed

  • Yes, I have reviewed the system requirements

Requirements affected by this story

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Risk assessment needed

  • Needed
  • Not needed

Risk assessment

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Can be closed when

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@khurrammaqbool khurrammaqbool added the User-Story A User-Story describing new functionality label Jun 5, 2024
@khurrammaqbool khurrammaqbool self-assigned this Jun 5, 2024
@mathiasbio mathiasbio added this to the Release 16 milestone Jun 5, 2024
@khurrammaqbool khurrammaqbool linked a pull request Jun 5, 2024 that will close this issue
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@khurrammaqbool khurrammaqbool linked a pull request Jun 24, 2024 that will close this issue
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@ivadym
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ivadym commented Jun 27, 2024

Can you make sure the System Requirements section is filled out and the Can be closed when section has all the relevant issues and PRs linked? If anything's missing, please open new issues

@khurrammaqbool khurrammaqbool linked a pull request Jun 28, 2024 that will close this issue
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@pbiology pbiology changed the title [User Story] ADD MSI analysis [User Story] Add MSI analysis Jul 1, 2024
@khurrammaqbool khurrammaqbool linked a pull request Jul 5, 2024 that will close this issue
54 tasks
@khurrammaqbool
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khurrammaqbool commented Sep 27, 2024

Store MSI score file in housekeeper to be able to fetch the scores from across the cases and analyse.

@khurrammaqbool
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khurrammaqbool commented Sep 27, 2024

Cases DRAGEN TN MSI BALSAMICv16 TN MSI
MSI1 80.359
MSI2 47.88
MSI3 60.979
MSI4 20.129
MSI5 48.28
MSI6 78.03
MSI7 81.579
MSI8 87.26
MSI9 70.68

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