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tp53.gb
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tp53.gb
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LOCUS NM_000546 2591 bp mRNA linear PRI 23-FEB-2019
DEFINITION Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA.
ACCESSION NM_000546
VERSION NM_000546.5 GI:371502114
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2591)
AUTHORS Marcel V, Tran PL, Sagne C, Martel-Planche G, Vaslin L,
Teulade-Fichou MP, Hall J, Mergny JL, Hainaut P and Van Dyck E.
TITLE G-quadruplex structures in TP53 intron 3: role in alternative
splicing and in production of p53 mRNA isoforms
JOURNAL Carcinogenesis 32 (3), 271-278 (2011)
PUBMED 21112961
REFERENCE 2 (bases 1 to 2591)
AUTHORS Marcel V, Perrier S, Aoubala M, Ageorges S, Groves MJ, Diot A,
Fernandes K, Tauro S and Bourdon JC.
TITLE Delta160p53 is a novel N-terminal p53 isoform encoded by
Delta133p53 transcript
JOURNAL FEBS Lett. 584 (21), 4463-4468 (2010)
PUBMED 20937277
REMARK GeneRIF: Delta133p53 transcript generates two different p53
isoforms, Delta133p53 and Delta160p53
REFERENCE 3 (bases 1 to 2591)
AUTHORS Anczukow O, Ware MD, Buisson M, Zetoune AB, Stoppa-Lyonnet D,
Sinilnikova OM and Mazoyer S.
TITLE Does the nonsense-mediated mRNA decay mechanism prevent the
synthesis of truncated BRCA1, CHK2, and p53 proteins?
JOURNAL Hum. Mutat. 29 (1), 65-73 (2008)
PUBMED 17694537
REMARK GeneRIF: the p53 protein encoded by the 770delT allele is as
abundant as the wild-type protein, as removal of the C-terminal p53
domain leads to a stabilized mutant protein, whose abundance is
markedly increased when NMD is inhibited.
REFERENCE 4 (bases 1 to 2591)
AUTHORS Bourdon JC.
TITLE p53 Family isoforms
JOURNAL Curr Pharm Biotechnol 8 (6), 332-336 (2007)
PUBMED 18289041
REMARK Review article
REFERENCE 5 (bases 1 to 2591)
AUTHORS Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K,
Vojtesek B, Bruzzoni-Giovanelli H and Fahraeus R.
TITLE Expression of p53 and p53/47 are controlled by alternative
mechanisms of messenger RNA translation initiation
JOURNAL Oncogene 25 (52), 6936-6947 (2006)
PUBMED 16983332
REMARK GeneRIF: harbouring alternative translation initiation sites, the
p53 mRNA gives rise to different levels of the p53 isoforms which
help to orchestrate the cell biological outcome of p53 activation
REFERENCE 6 (bases 1 to 2591)
AUTHORS Murray-Zmijewski F, Lane DP and Bourdon JC.
TITLE p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell
differentiation and response to stress
JOURNAL Cell Death Differ. 13 (6), 962-972 (2006)
PUBMED 16601753
REMARK Review article
REFERENCE 7 (bases 1 to 2591)
AUTHORS Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A,
Xirodimas DP, Saville MK and Lane DP.
TITLE p53 isoforms can regulate p53 transcriptional activity
JOURNAL Genes Dev. 19 (18), 2122-2137 (2005)
PUBMED 16131611
REMARK GeneRIF: p53 isoforms can regulate p53 transcriptional activity.
REFERENCE 8 (bases 1 to 2591)
AUTHORS Ghosh A, Stewart D and Matlashewski G.
TITLE Regulation of human p53 activity and cell localization by
alternative splicing
JOURNAL Mol. Cell. Biol. 24 (18), 7987-7997 (2004)
PUBMED 15340061
REMARK GeneRIF: mechanism of p53 regulation originating through
alternative splicing of the human p53 gene resulting in the
expression of a novel p53 mRNA
REFERENCE 9 (bases 1 to 2591)
AUTHORS Yin Y, Stephen CW, Luciani MG and Fahraeus R.
TITLE p53 Stability and activity is regulated by Mdm2-mediated induction
of alternative p53 translation products
JOURNAL Nat. Cell Biol. 4 (6), 462-467 (2002)
PUBMED 12032546
REMARK Erratum:[Nat Cell Biol 2002 Nov;4(11):912]
REFERENCE 10 (bases 1 to 2591)
AUTHORS Flaman JM, Waridel F, Estreicher A, Vannier A, Limacher JM, Gilbert
D, Iggo R and Frebourg T.
TITLE The human tumour suppressor gene p53 is alternatively spliced in
normal cells
JOURNAL Oncogene 12 (4), 813-818 (1996)
PUBMED 8632903
REFERENCE 11 (bases 1 to 2591)
AUTHORS Schneider,K., Zelley,K., Nichols,K.E. and Garber,J.
TITLE Li-Fraumeni Syndrome
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301488
REFERENCE 12 (bases 1 to 2591)
AUTHORS Dome,J.S. and Huff,V.
TITLE Wilms Tumor Predisposition
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301471
REFERENCE 13 (bases 1 to 2591)
AUTHORS Lamb,P. and Crawford,L.
TITLE Characterization of the human p53 gene
JOURNAL Mol. Cell. Biol. 6 (5), 1379-1385 (1986)
PUBMED 2946935
REFERENCE 14 (bases 1 to 2591)
AUTHORS Isobe,M., Emanuel,B.S., Givol,D., Oren,M. and Croce,C.M.
TITLE Localization of gene for human p53 tumour antigen to band 17p13
JOURNAL Nature 320 (6057), 84-85 (1986)
PUBMED 3456488
REFERENCE 15 (bases 1 to 2591)
AUTHORS Benchimol,S., Lamb,P., Crawford,L.V., Sheer,D., Shows,T.B.,
Bruns,G.A. and Peacock,J.
TITLE Transformation associated p53 protein is encoded by a gene on human
chromosome 17
JOURNAL Somat. Cell Mol. Genet. 11 (5), 505-510 (1985)
PUBMED 2994241
REFERENCE 16 (bases 1 to 2591)
AUTHORS Harlow,E., Williamson,N.M., Ralston,R., Helfman,D.M. and Adams,T.E.
TITLE Molecular cloning and in vitro expression of a cDNA clone for human
cellular tumor antigen p53
JOURNAL Mol. Cell. Biol. 5 (7), 1601-1610 (1985)
PUBMED 3894933
REFERENCE 17 (bases 1 to 2591)
AUTHORS Zakut-Houri,R., Bienz-Tadmor,B., Givol,D. and Oren,M.
TITLE Human p53 cellular tumor antigen: cDNA sequence and expression in
COS cells
JOURNAL EMBO J. 4 (5), 1251-1255 (1985)
PUBMED 4006916
REFERENCE 18 (bases 1 to 2591)
AUTHORS Matlashewski,G., Lamb,P., Pim,D., Peacock,J., Crawford,L. and
Benchimol,S.
TITLE Isolation and characterization of a human p53 cDNA clone:
expression of the human p53 gene
JOURNAL EMBO J. 3 (13), 3257-3262 (1984)
PUBMED 6396087
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA453049.1, X02469.1,
AK223026.1 and DQ186650.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 7, 2012 this sequence version replaced NM_000546.4.
Summary: This gene encodes a tumor suppressor protein containing
transcriptional activation, DNA binding, and oligomerization
domains. The encoded protein responds to diverse cellular stresses
to regulate expression of target genes, thereby inducing cell cycle
arrest, apoptosis, senescence, DNA repair, or changes in
metabolism. Mutations in this gene are associated with a variety of
human cancers, including hereditary cancers such as Li-Fraumeni
syndrome. Alternative splicing of this gene and the use of
alternate promoters result in multiple transcript variants and
isoforms. Additional isoforms have also been shown to result from
the use of alternate translation initiation codons from identical
transcript variants (PMIDs: 12032546, 20937277). [provided by
RefSeq, Dec 2016].
Transcript Variant: This variant (1) can initiate translation from
two in-frame AUG start codons. The isoform represented in this
variant (a, also known as p53alpha) results from translation
initiation at the upstream start codon. Both variants 1 and 2
encode isoform a, which is the longest isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: HG975427.1, DQ191317.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-67 DA453049.1 1-67
68-1384 X02469.1 1-1317
1385-2572 AK223026.1 478-1665
2573-2591 DQ186650.1 2257-2275
FEATURES Location/Qualifiers
source 1..2591
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.1"
gene 1..2591
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/note="tumor protein p53"
/db_xref="GeneID:7157"
/db_xref="HGNC:HGNC:11998"
/db_xref="MIM:191170"
exon 1..174
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
misc_feature 95..97
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/note="upstream in-frame stop codon"
exon 175..276
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
CDS 203..1384
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/note="isoform a is encoded by transcript variant 1; tumor
protein 53; mutant tumor protein 53; cellular tumor
antigen p53; phosphoprotein p53; transformation-related
protein 53; p53 tumor suppressor; antigen NY-CO-13; tumor
supressor p53"
/codon_start=1
/product="cellular tumor antigen p53 isoform a"
/protein_id="NP_000537.3"
/db_xref="GI:120407068"
/db_xref="CCDS:CCDS11118.1"
/db_xref="GeneID:7157"
/db_xref="HGNC:HGNC:11998"
/db_xref="MIM:191170"
/translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLM
LSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKT
YQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAM
AIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVV
PYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA
CPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRG
RERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDS
D"
misc_feature 203..1162
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with CCAR2.
{ECO:0000269|PubMed:25732823}"
misc_feature 203..451
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with HRMT1L2.
{ECO:0000269|PubMed:15186775}"
misc_feature 203..334
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Transcription activation (acidic)"
misc_feature 227..229
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by HIPK4.
{ECO:0000269|PubMed:18022393}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 245..247
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK5, PRPK, AMPK, NUAK1 and ATM.
{ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766,
ECO:0000269|PubMed:15701641, ECO:0000269|PubMed:15866171,
ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690,
ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932};
propagated from UniProtKB/Swiss-Prot (P04637.4);
phosphorylation site"
misc_feature 251..277
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: TADI"
misc_feature 254..256
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by CK1, VRK1 and VRK2.
{ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572,
ECO:0000269|PubMed:16704422}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 260..262
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CHEK2, CK1 and PLK3.
{ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225,
ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724,
ECO:0000269|PubMed:20041275}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 299..301
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK5 and CDK7.
{ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954};
propagated from UniProtKB/Swiss-Prot (P04637.4);
phosphorylation site"
misc_feature 311..313
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPKAPK5.
{ECO:0000269|PubMed:17254968}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 320..322
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/note="delta40p53alpha; Region: alternative start codon"
misc_feature 338..340
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK5, DYRK2, HIPK2 and PKC/PRKCG.
{ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126,
ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958,
ECO:0000269|PubMed:17591690}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 344..370
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: TADII"
misc_feature 365..367
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by TAF1 and GRK5.
{ECO:0000269|PubMed:15053879,
ECO:0000269|PubMed:20124405}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 398..532
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with WWOX"
misc_feature 500..1312
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with HIPK1. {ECO:0000250}"
misc_feature 500..1102
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Required for interaction with ZNF385A.
{ECO:0000269|PubMed:17719541}"
misc_feature 539..910
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Required for interaction with FBXO42.
{ECO:0000269|PubMed:19509332}"
misc_feature 548..1078
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with AXIN1. {ECO:0000250}"
misc_feature 560..562
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Interaction with DNA; propagated from
UniProtKB/Swiss-Prot (P04637.4); other site"
misc_feature 560..562
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, by KAT6A.
{ECO:0000269|PubMed:23431171}; propagated from
UniProtKB/Swiss-Prot (P04637.4); acetylation site"
misc_feature 749..751
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by AURKB.
{ECO:0000269|PubMed:20959462}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 923..946
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with the 53BP2 SH3 domain"
misc_feature 968..1084
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with E4F1.
{ECO:0000269|PubMed:10644996}"
misc_feature 1007..1009
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by AURKB.
{ECO:0000269|PubMed:20959462}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 1019..1042
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with DNA"
misc_feature 1052..1054
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by AURKB.
{ECO:0000269|PubMed:20959462}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 1100..1381
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with CARM1.
{ECO:0000269|PubMed:15186775}"
misc_feature 1115..1165
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Bipartite nuclear localization signal"
misc_feature 1115..1117
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000269|PubMed:12724314};
propagated from UniProtKB/Swiss-Prot (P04637.4);
acetylation site"
misc_feature 1145..1147
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by AURKA, CDK1 and CDK2.
{ECO:0000269|PubMed:10884347,
ECO:0000269|PubMed:14702041}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
misc_feature 1157..1282
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with HIPK2"
misc_feature 1163..1165
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000250|UniProtKB:P02340};
propagated from UniProtKB/Swiss-Prot (P04637.4);
acetylation site"
misc_feature 1175..1270
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Oligomerization"
misc_feature 1217..1252
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Nuclear export signal"
misc_feature 1277..1291
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Interaction with USP7"
misc_feature 1304..1363
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: Basic (repression of DNA-binding)"
misc_feature 1310..1318
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04637.4);
Region: [KR]-[STA]-K motif"
misc_feature 1310..1312
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6-dimethyllysine, alternate.
{ECO:0000269|PubMed:17108971,
ECO:0000269|PubMed:22864287}; N6-methyllysine, by SMYD2,
alternate. {ECO:0000269|PubMed:17108971,
ECO:0000269|PubMed:22864287}; propagated from
UniProtKB/Swiss-Prot (P04637.4); methylation site"
misc_feature 1316..1318
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-methyllysine, by SETD7.
{ECO:0000269|PubMed:15525938,
ECO:0000269|PubMed:16415881}; propagated from
UniProtKB/Swiss-Prot (P04637.4); methylation site"
misc_feature 1319..1321
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6-dimethyllysine, by EHMT1 and EHMT2,
alternate. {ECO:0000269|PubMed:20118233}; propagated from
UniProtKB/Swiss-Prot (P04637.4); methylation site"
misc_feature 1319..1321
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate.
{ECO:0000269|PubMed:10656795}; propagated from
UniProtKB/Swiss-Prot (P04637.4); acetylation site"
misc_feature 1343..1345
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine. {ECO:0000244|PubMed:19608861};
propagated from UniProtKB/Swiss-Prot (P04637.4);
acetylation site"
misc_feature 1346..1348
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6-dimethyllysine, alternate.
{ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725,
ECO:0000269|PubMed:22864287}; N6-methyllysine, by KMT5A,
alternate. {ECO:0000269|PubMed:17707234,
ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287};
propagated from UniProtKB/Swiss-Prot (P04637.4);
methylation site"
misc_feature 1346..1348
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, by KAT6A, alternate.
{ECO:0000244|PubMed:19608861, ECO:0000269|PubMed:10656795,
ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:23431171};
propagated from UniProtKB/Swiss-Prot (P04637.4);
acetylation site"
misc_feature 1376..1378
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK2, CDK2 and NUAK1.
{ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457,
ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932,
ECO:0000269|PubMed:22214662}; propagated from
UniProtKB/Swiss-Prot (P04637.4); phosphorylation site"
exon 277..298
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
exon 299..577
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
STS 305..503
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="GDB:177814"
/db_xref="UniSTS:154969"
STS 319..577
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="GDB:177797"
/db_xref="UniSTS:154963"
exon 578..761
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
STS 680..754
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="PMC340938P3"
/db_xref="UniSTS:273171"
exon 762..874
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
exon 875..984
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
STS 955..1153
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="PMC310707P2"
/db_xref="UniSTS:272633"
STS 959..1033
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="GDB:190076"
/db_xref="UniSTS:155620"
exon 985..1121
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
exon 1122..1195
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
exon 1196..1302
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
exon 1303..2591
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/inference="alignment:Splign:2.1.0"
STS 1454..1570
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="D17S1678"
/db_xref="UniSTS:82485"
STS 1911..2057
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="D17S1506E"
/db_xref="UniSTS:151711"
STS 2446..2522
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/standard_name="WI-20715"
/db_xref="UniSTS:59997"
regulatory 2555..2560
/regulatory_class="polyA_signal_sequence"
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
polyA_site 2572
/gene="TP53"
/gene_synonym="BCC7; BMFS5; LFS1; P53; TRP53"
/note="The 3' most polyA site has not been determined."
ORIGIN
1 gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt
61 ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt
121 gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca
181 gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc
241 tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc
301 ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg
361 gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt
421 ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct
481 gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt
541 cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat
601 gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc
661 cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt
721 gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca
781 tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg
841 acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca
901 ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac
961 catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg
1021 tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg
1081 ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag
1141 ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg
1201 tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc
1261 ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa
1321 gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga
1381 ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc
1441 tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac
1501 ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt
1561 tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac
1621 tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc
1681 agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg
1741 ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc
1801 acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta
1861 ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg
1921 gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct
1981 gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa
2041 tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac
2101 caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt
2161 ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc
2221 ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg
2281 gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc
2341 tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc
2401 ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc
2461 ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt
2521 tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg
2581 tctgaggggt g
//