diff --git a/requirements.txt b/requirements.txt
index 5ed1d8e5..ad17edb0 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -16,7 +16,7 @@ colorama==0.3.9
 commonmark==0.9.1
 connexion==2.3.0
 crc32c==1.7
-cryptography==2.3.1
+cryptography==3.2
 dcplib==3.12.0
 docutils==0.15.2
 Flask==1.1.1
@@ -27,7 +27,7 @@ hca==6.4.0
 idna==2.8
 inflection==0.3.1
 itsdangerous==1.1.0
-Jinja2==2.10.3
+Jinja2==2.11.3
 jmespath==0.9.4
 jsonpointer==1.14
 jsonschema==2.6.0
@@ -40,13 +40,13 @@ puremagic==1.4
 pyasn1==0.4.7
 pyasn1-modules==0.2.7
 pycparser==2.19
-PyJWT==1.7.1
+PyJWT==2.4.0
 python-dateutil==2.8.0
-PyYAML==5.1.1
+PyYAML==5.4
 requests==2.22.0
 requests-http-signature==0.1.0
 requests-oauthlib==1.2.0
-rsa==3.4.2
+rsa==4.7
 s3transfer==0.2.1
 six==1.12.0
 SQLAlchemy==1.3.10
@@ -54,5 +54,5 @@ swagger-ui-bundle==0.0.5
 tenacity==5.0.4
 termcolor==1.1.0
 tweak==1.0.3
-urllib3==1.24.3
+urllib3==1.26.5
 Werkzeug==0.15.6