diff --git a/pkgs/tools/X11/xpra/default.nix b/pkgs/tools/X11/xpra/default.nix
index 625dde8f825cc..76049c51d21d2 100644
--- a/pkgs/tools/X11/xpra/default.nix
+++ b/pkgs/tools/X11/xpra/default.nix
@@ -1,6 +1,5 @@
 { lib
 , fetchFromGitHub
-, substituteAll
 , pkg-config
 , runCommand
 , writeText
@@ -38,6 +37,7 @@
 , xdg-utils
 , xorg
 , xorgserver
+, xxHash
 }:
 
 let
@@ -70,20 +70,16 @@ let
   '';
 in buildPythonApplication rec {
   pname = "xpra";
-  version = "5.0.9";
+  version = "6.1.2";
 
   src = fetchFromGitHub {
     owner = "Xpra-org";
     repo = "xpra";
     rev = "v${version}";
-    hash = "sha256-gwo5plCAryGC8/BKVEqyMkgB+3FM8HXG6sESomDOtNM=";
+    hash = "sha256-SmX0zwScyosiidBdW18vP3tV7BJfYfOmXwuRUbb+gX8=";
   };
 
   patches = [
-    (substituteAll {  # correct hardcoded paths
-      src = ./fix-paths.patch;
-      inherit libfakeXinerama;
-    })
     ./fix-41106.patch  # https://github.com/NixOS/nixpkgs/issues/41106
     ./fix-122159.patch # https://github.com/NixOS/nixpkgs/issues/122159
   ];
@@ -137,6 +133,7 @@ in buildPythonApplication rec {
     pango
     x264
     x265
+    xxHash
   ] ++ lib.optional withNvenc nvencHeaders;
 
   propagatedBuildInputs = with python3.pkgs; ([
diff --git a/pkgs/tools/X11/xpra/fix-122159.patch b/pkgs/tools/X11/xpra/fix-122159.patch
index 5fe2ce3892fd8..58efa07e790d7 100644
--- a/pkgs/tools/X11/xpra/fix-122159.patch
+++ b/pkgs/tools/X11/xpra/fix-122159.patch
@@ -1,16 +1,18 @@
 diff --git a/xpra/scripts/main.py b/xpra/scripts/main.py
-index 58c8bf6464..36f4b3cd3d 100755
+index 7806612e05..4c7a0ec2dd 100755
 --- a/xpra/scripts/main.py
 +++ b/xpra/scripts/main.py
-@@ -389,11 +389,7 @@ def run_mode(script_file:str, cmdline, error_cb, options, args, mode:str, defaul
-         "seamless", "desktop", "shadow", "shadow-screen", "expand",
-         "upgrade", "upgrade-seamless", "upgrade-desktop",
-         ) and not display_is_remote and use_systemd_run(options.systemd_run):
--        #make sure we run via the same interpreter,
--        #inject it into the command line if we have to:
+@@ -444,13 +444,7 @@ def run_mode(script_file: str, cmdline, error_cb, options, args, full_mode: str,
+             "seamless", "desktop", "shadow", "shadow-screen", "expand",
+             "upgrade", "upgrade-seamless", "upgrade-desktop",
+     ) and not display_is_remote and options.daemon and use_systemd_run(options.systemd_run):
+-        # make sure we run via the same interpreter,
+-        # inject it into the command line if we have to:
          argv = list(cmdline)
--        if argv[0].find("python")<0:
--            argv.insert(0, "python%i.%i" % (sys.version_info.major, sys.version_info.minor))
-         return systemd_run_wrap(mode, argv, options.systemd_run_args, user=getuid()!=0)
+-        if argv[0].find("python") < 0:
+-            major, minor = sys.version_info.major, sys.version_info.minor
+-            python = which("python%i.%i" % (major, minor)) or which("python%i" % major) or which("python") or "python"
+-            argv.insert(0, python)
+         return systemd_run_wrap(mode, argv, options.systemd_run_args, user=getuid() != 0)
      configure_env(options.env)
      configure_logging(options, mode)
diff --git a/pkgs/tools/X11/xpra/fix-41106.patch b/pkgs/tools/X11/xpra/fix-41106.patch
index a1a74a01c3fe9..84061106323c6 100644
--- a/pkgs/tools/X11/xpra/fix-41106.patch
+++ b/pkgs/tools/X11/xpra/fix-41106.patch
@@ -1,11 +1,11 @@
-diff --git a/xpra/server/server_util.py b/xpra/server/server_util.py
-index 2e83712bb8..2dd0bf73d2 100644
---- a/xpra/server/server_util.py
-+++ b/xpra/server/server_util.py
-@@ -166,6 +166,10 @@ def xpra_env_shell_script(socket_dir, env : Dict[str,str]) -> str:
-     return "\n".join(script)
+diff --git a/xpra/server/util.py b/xpra/server/util.py
+index 401a9fb959..678e2ce745 100644
+--- a/xpra/server/util.py
++++ b/xpra/server/util.py
+@@ -175,6 +175,10 @@ def xpra_env_shell_script(socket_dir: str, env: dict[str, str]) -> str:
  
- def xpra_runner_shell_script(xpra_file:str, starting_dir:str) -> str:
+ 
+ def xpra_runner_shell_script(xpra_file: str, starting_dir: str) -> str:
 +    # Nixpkgs contortion:
 +    # xpra_file points to a shell wrapper, not to the python script.
 +    dirname, basename = os.path.split(xpra_file)
diff --git a/pkgs/tools/X11/xpra/fix-paths.patch b/pkgs/tools/X11/xpra/fix-paths.patch
deleted file mode 100644
index 43210f4f15d6f..0000000000000
--- a/pkgs/tools/X11/xpra/fix-paths.patch
+++ /dev/null
@@ -1,37 +0,0 @@
-diff --git a/xpra/x11/fakeXinerama.py b/xpra/x11/fakeXinerama.py
-index a5289e0e43..527cdf90c9 100755
---- a/xpra/x11/fakeXinerama.py
-+++ b/xpra/x11/fakeXinerama.py
-@@ -23,31 +23,7 @@ fakeXinerama_config_files = [
-            ]
- 
- def find_libfakeXinerama():
--    libname = "fakeXinerama"
--    try:
--        from ctypes.util import find_library
--        flibname = find_library("fakeXinerama")
--        if flibname:
--            libname = flibname
--    except Exception:
--        pass
--    if POSIX:
--        for lib_dir in os.environ.get("LD_LIBRARY_PATH", "/usr/lib").split(os.pathsep):
--            lib_path = os.path.join(lib_dir, libname)
--            if not os.path.exists(lib_dir):
--                continue
--            if os.path.exists(lib_path) and os.path.isfile(lib_path):
--                return lib_path
--    if LINUX:
--        try:
--            libpath = find_lib_ldconfig("fakeXinerama")
--            if libpath:
--                return libpath
--        except Exception as e:
--            log("find_libfakeXinerama()", exc_info=True)
--            log.error("Error: cannot launch ldconfig -p to locate libfakeXinerama:")
--            log.estr(e)
--    return find_lib("libfakeXinerama.so.1")
-+    return "@libfakeXinerama@/lib/libfakeXinerama.so.1.0"
- 
- current_xinerama_config = None
-