diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419.py b/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419.py
index 311364095af1e..480f6a4daadd0 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_comprehensions/C419.py
@@ -55,3 +55,14 @@ async def f() -> bool:
 
 # should not be linted...
 sum({x.id for x in bar})
+
+
+# https://github.com/astral-sh/ruff/issues/12891
+from collections.abc import AsyncGenerator
+
+
+async def test() -> None:
+    async def async_gen() -> AsyncGenerator[bool, None]:
+        yield True
+
+    assert all([v async for v in async_gen()])  # OK
diff --git a/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs b/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
index 6897e224f3bbe..12dcb9842c2d8 100644
--- a/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
+++ b/crates/ruff_linter/src/rules/flake8_comprehensions/rules/unnecessary_comprehension_in_call.rs
@@ -100,14 +100,21 @@ pub(crate) fn unnecessary_comprehension_in_call(
     let Some(arg) = args.first() else {
         return;
     };
-    let (Expr::ListComp(ast::ExprListComp { elt, .. })
-    | Expr::SetComp(ast::ExprSetComp { elt, .. })) = arg
+    let (Expr::ListComp(ast::ExprListComp {
+        elt, generators, ..
+    })
+    | Expr::SetComp(ast::ExprSetComp {
+        elt, generators, ..
+    })) = arg
     else {
         return;
     };
     if contains_await(elt) {
         return;
     }
+    if generators.iter().any(|generator| generator.is_async) {
+        return;
+    }
     let Some(Ok(builtin_function)) = checker
         .semantic()
         .resolve_builtin_symbol(func)