diff --git a/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts b/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
index 7e3cedf219e09..d186d00987317 100644
--- a/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
+++ b/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
@@ -9,7 +9,6 @@ import { ISubnet, IVpc, SubnetSelection } from './vpc';
 import * as iam from '../../aws-iam';
 import * as cxschema from '../../cloud-assembly-schema';
 import { Aws, ContextProvider, IResource, Lazy, Resource, Stack, Token } from '../../core';
-import { PARTITION_MAP } from '../../region-info/build-tools/fact-tables';
 
 /**
  * A VPC endpoint.
@@ -667,21 +666,8 @@ export class InterfaceVpcEndpointAwsService implements IInterfaceVpcEndpointServ
         'redshift', 'redshift-data', 's3', 'sagemaker.api', 'sagemaker.featurestore-runtime', 'sagemaker.runtime', 'securityhub',
         'servicecatalog', 'sms', 'sqs', 'states', 'sts', 'sync-states', 'synthetics', 'transcribe', 'transcribestreaming', 'transfer',
         'workspaces', 'xray'],
-      'us-isof-': ['ecr.api', 'ecr.dkr'],
-      'eu-isoe-': ['ecr.api', 'ecr.dkr'],
     };
-
-    const regionPartition = region.split('-').slice(0, 2).join('-');
-    const partitionDetails = PARTITION_MAP[`${regionPartition}-`];
-
-    // Check for specific service name under isolated region prefix
-    const serviceInExceptions = VPC_ENDPOINT_SERVICE_EXCEPTIONS[`${regionPartition}-`]?.includes(name);
-
-    if (serviceInExceptions) {
-      // Endpoints generated in reverse of domain suffix for the services mentioned in map
-      const reverseString = partitionDetails.domainSuffix.split('.').reverse().join('.');
-      return reverseString;
-    } else if (VPC_ENDPOINT_SERVICE_EXCEPTIONS[region]?.includes(name)) {
+    if (VPC_ENDPOINT_SERVICE_EXCEPTIONS[region]?.includes(name)) {
       return 'cn.com.amazonaws';
     } else {
       return 'com.amazonaws';
diff --git a/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts b/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
index 2e9ae880d7147..3c1c05ba8dfa8 100644
--- a/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
+++ b/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
@@ -694,37 +694,6 @@ describe('vpc endpoint', () => {
       });
 
     });
-
-    test.each([
-      ['us-isof-test-1', 'gov.ic.hci.csp'],
-      ['eu-isoe-test-1', 'uk.adc-e.cloud'],
-      ['us-east-1', 'com.amazonaws'],
-      ['us-gov-west-1', 'com.amazonaws'],
-      ['cn-northwest-1', 'cn.com.amazonaws'],
-      ['cn-north-1', 'cn.com.amazonaws'],
-    ])('test vpc interface endpoint for ECR can be created correctly in all regions', (region : string, domain: string) => {
-      //GIVEN
-      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region: region } });
-      const vpc = new Vpc(stack, 'VPC');
-
-      //WHEN
-      vpc.addInterfaceEndpoint('ECR Endpoint', {
-        service: InterfaceVpcEndpointAwsService.ECR,
-      });
-
-      vpc.addInterfaceEndpoint('ECR Docker Endpoint', {
-        service: InterfaceVpcEndpointAwsService.ECR_DOCKER,
-      });
-
-      //THEN
-      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
-        ServiceName: `${domain}.${region}.ecr.api`,
-      });
-      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
-        ServiceName: `${domain}.${region}.ecr.dkr`,
-      });
-    });
-
     test.each([
       ['transcribe', InterfaceVpcEndpointAwsService.TRANSCRIBE],
     ])('test vpc interface endpoint with .cn suffix for %s can be created correctly in China regions', (name: string, given: InterfaceVpcEndpointAwsService) => {