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Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants

This repo contains data and code for the analyses presented in Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants, PNAS, 2024.

Directory structure

Rcivaclib and civaclib: R and Python code, respectively.

bin: Bin scripts

data: Raw data and code to generate antigenic maps.

figures: Code to generate the figures shown in the paper, as well as the resulting figures.

test: Tests.

Dependencies

All dependencies for R are listed in the DEPENDENCIES file. Apart from the dependencies available through CRAN, the following packages specific to antigenic cartography and titer analysis are required:

Racmacs

Available from github.com/shwilks/Racmacs, or through CRAN.

titertools

Available from github.com/shwilks/titertools.

Furthermore, for Python, the following libraries need to be installed: neutcurve, pandas, numpy.