diff --git a/packages/react-relay/multi-actor/__tests__/ActorChange-test.js b/packages/react-relay/multi-actor/__tests__/ActorChange-test.js
index 07f120bffb576..7196b99c87a80 100644
--- a/packages/react-relay/multi-actor/__tests__/ActorChange-test.js
+++ b/packages/react-relay/multi-actor/__tests__/ActorChange-test.js
@@ -131,7 +131,7 @@ type Props = $ReadOnly<{
 
 function ActorMessage(props: Props) {
   const data = useFragment(fragment, props.myFragment);
-  const [commit] = useMutation<$FlowFixMe>(mutation);
+  const [commit] = useMutation(mutation);
 
   // We're calling this hook only to verify that it won't throw.
   // `useRelayActorEnvironment` should be able to have access to `getEnvironmentForActor` function
@@ -146,7 +146,9 @@ function ActorMessage(props: Props) {
         onClick={() =>
           commit({
             variables: {
-              feedbackID: 'feedback:1234',
+              input: {
+                feedbackId: 'feedback:1234',
+              },
             },
           })
         }
diff --git a/packages/react-relay/multi-actor/__tests__/ActorChangeWithMutation-test.js b/packages/react-relay/multi-actor/__tests__/ActorChangeWithMutation-test.js
index cddec48250bfb..48b837b61e715 100644
--- a/packages/react-relay/multi-actor/__tests__/ActorChangeWithMutation-test.js
+++ b/packages/react-relay/multi-actor/__tests__/ActorChangeWithMutation-test.js
@@ -144,7 +144,7 @@ type Props = $ReadOnly<{
 
 function ActorComponent(props: Props) {
   const data = useFragment(fragment, props.fragmentKey);
-  const [commit] = useMutation<ActorChangeWithMutationTestMutation>(mutation);
+  const [commit] = useMutation(mutation);
 
   props.render({
     id: data.id,
diff --git a/packages/react-relay/relay-hooks/__tests__/useMutation-fast-refresh-test.js b/packages/react-relay/relay-hooks/__tests__/useMutation-fast-refresh-test.js
index 8dc8780d862cb..7413cd3ab02f0 100644
--- a/packages/react-relay/relay-hooks/__tests__/useMutation-fast-refresh-test.js
+++ b/packages/react-relay/relay-hooks/__tests__/useMutation-fast-refresh-test.js
@@ -42,7 +42,7 @@ describe('useLazyLoadQueryNode', () => {
 
   const variables = {
     input: {
-      commentId: '<id>',
+      feedbackId: '<id>',
     },
   };
   beforeEach(() => {
@@ -82,9 +82,7 @@ describe('useLazyLoadQueryNode', () => {
     ReactRefreshRuntime.injectIntoGlobalHook(global);
     let commit;
     const V1 = function (props: {}) {
-      const [commitFn, isMutationInFlight] = useMutation<any>(
-        CommentCreateMutation,
-      );
+      const [commitFn, isMutationInFlight] = useMutation(CommentCreateMutation);
       commit = commitFn;
       return isInFlightFn(isMutationInFlight);
     };
@@ -118,9 +116,7 @@ describe('useLazyLoadQueryNode', () => {
 
     // Trigger a fast fresh
     function V2(props: any) {
-      const [commitFn, isMutationInFlight] = useMutation<any>(
-        CommentCreateMutation,
-      );
+      const [commitFn, isMutationInFlight] = useMutation(CommentCreateMutation);
       commit = commitFn;
       return isInFlightFn(isMutationInFlight);
     }
diff --git a/packages/react-relay/relay-hooks/__tests__/useMutation-test.js b/packages/react-relay/relay-hooks/__tests__/useMutation-test.js
index dd280b182fe8d..4df992ffee7f8 100644
--- a/packages/react-relay/relay-hooks/__tests__/useMutation-test.js
+++ b/packages/react-relay/relay-hooks/__tests__/useMutation-test.js
@@ -94,7 +94,7 @@ beforeEach(() => {
   }) {
     const [mutation, setMutationFn] = useState(initialMutation);
     setMutation = setMutationFn;
-    const [commitFn, isMutationInFlight] = useMutation<any>(mutation);
+    const [commitFn, isMutationInFlight] = useMutation(mutation);
     commit = (config: any) =>
       ReactTestRenderer.act(() => {
         disposable = commitFn(config);
diff --git a/packages/react-relay/relay-hooks/useMutation.js b/packages/react-relay/relay-hooks/useMutation.js
index dd5ccc8e1397b..d7dfa82820748 100644
--- a/packages/react-relay/relay-hooks/useMutation.js
+++ b/packages/react-relay/relay-hooks/useMutation.js
@@ -14,13 +14,14 @@
 import type {
   DeclarativeMutationConfig,
   Disposable,
-  GraphQLTaggedNode,
   IEnvironment,
+  Mutation,
   MutationConfig,
   MutationParameters,
   PayloadError,
   SelectorStoreUpdater,
   UploadableMap,
+  Variables,
 } from 'relay-runtime';
 
 const useIsMountedRef = require('./useIsMountedRef');
@@ -50,13 +51,39 @@ export type UseMutationConfig<TMutation: MutationParameters> = {
   variables: TMutation['variables'],
 };
 
-function useMutation<TMutation: MutationParameters>(
-  mutation: GraphQLTaggedNode,
+type UseMutationConfigInternal<TVariables, TData, TRawResponse> = {
+  configs?: Array<DeclarativeMutationConfig>,
+  onError?: ?(error: Error) => void,
+  onCompleted?: ?(response: TData, errors: ?Array<PayloadError>) => void,
+  onNext?: ?() => void,
+  onUnsubscribe?: ?() => void,
+  optimisticResponse?: TRawResponse,
+  optimisticUpdater?: ?SelectorStoreUpdater<TData>,
+  updater?: ?SelectorStoreUpdater<TData>,
+  uploadables?: UploadableMap,
+  variables: TVariables,
+};
+
+function useMutation<TVariables: Variables, TData, TRawResponse = {...}>(
+  mutation: Mutation<TVariables, TData, TRawResponse>,
   commitMutationFn?: (
     environment: IEnvironment,
-    config: MutationConfig<TMutation>,
+    config: MutationConfig<{
+      variables: TVariables,
+      /* $FlowFixMe[incompatible-type-arg] error exposed when improving flow
+       * typing of useMutation */
+      response: TData,
+      /* $FlowFixMe[incompatible-type-arg] error exposed when improving flow
+       * typing of useMutation */
+      rawResponse?: TRawResponse,
+    }>,
+    /* $FlowFixMe[incompatible-type-arg] error exposed when improving flow typing
+     * of useMutation */
   ) => Disposable = defaultCommitMutation,
-): [(UseMutationConfig<TMutation>) => Disposable, boolean] {
+): [
+  (UseMutationConfigInternal<TVariables, TData, TRawResponse>) => Disposable,
+  boolean,
+] {
   const environment = useRelayEnvironment();
   const isMountedRef = useIsMountedRef();
   const environmentRef = useRef(environment);
@@ -94,18 +121,18 @@ function useMutation<TMutation: MutationParameters>(
   }, [environment, isMountedRef, mutation]);
 
   const commit = useCallback(
-    (config: UseMutationConfig<TMutation>) => {
+    (config: UseMutationConfigInternal<TVariables, TData, TRawResponse>) => {
       if (isMountedRef.current) {
         setMutationInFlight(true);
       }
       const disposable: Disposable = commitMutationFn(environment, {
         ...config,
         mutation,
-        onCompleted: (response, errors) => {
+        onCompleted: (response: TData, errors: ?Array<PayloadError>) => {
           cleanup(disposable);
           config.onCompleted?.(response, errors);
         },
-        onError: error => {
+        onError: (error: Error) => {
           cleanup(disposable);
           config.onError?.(error);
         },