diff --git a/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.expected b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.expected
new file mode 100644
index 0000000000000..71cb70653bb5b
--- /dev/null
+++ b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.expected
@@ -0,0 +1,43 @@
+==================================== INPUT ====================================
+# expected-to-throw
+query relayResolverEdgeToInterfaceWithChildInterfaceAndNoImplementorsQuery {
+  resolver_field {
+    name
+  }
+}
+
+# %extensions%
+
+"""
+An interface with no concrete implementors
+"""
+interface SomeInterface {
+  name: String
+}
+
+interface ChildInterface implements SomeInterface {
+  name: String
+  age: Int
+}
+
+extend type Query {
+  resolver_field: SomeInterface
+    @relay_resolver(import_path: "./path/to/Resolver.js")
+}
+==================================== ERROR ====================================
+✖︎ Client Edges that reference client-defined interface types are not currently supported in Relay.
+
+  relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql:3:3
+    2 │ query relayResolverEdgeToInterfaceWithChildInterfaceAndNoImplementorsQuery {
+    3 │   resolver_field {
+      │   ^^^^^^^^^^^^^^
+    4 │     name
+
+
+✖︎ No types implement the client interface SomeInterface. Interfaces returned by a @RelayResolver must have at least one concrete implementation.
+
+  <generated>:2:44
+    1 │ # expected-to-throw
+    2 │ query relayResolverEdgeToInterfaceWithChildInterfaceAndNoImplementorsQuery {
+      │                                            ^^^^^^^^^^^^^
+    3 │   resolver_field {
diff --git a/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql
new file mode 100644
index 0000000000000..996b9886d6989
--- /dev/null
+++ b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql
@@ -0,0 +1,25 @@
+# expected-to-throw
+query relayResolverEdgeToInterfaceWithChildInterfaceAndNoImplementorsQuery {
+  resolver_field {
+    name
+  }
+}
+
+# %extensions%
+
+"""
+An interface with no concrete implementors
+"""
+interface SomeInterface {
+  name: String
+}
+
+interface ChildInterface implements SomeInterface {
+  name: String
+  age: Int
+}
+
+extend type Query {
+  resolver_field: SomeInterface
+    @relay_resolver(import_path: "./path/to/Resolver.js")
+}
diff --git a/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.expected b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.expected
new file mode 100644
index 0000000000000..52481f5e54510
--- /dev/null
+++ b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.expected
@@ -0,0 +1,38 @@
+==================================== INPUT ====================================
+# expected-to-throw
+query relayResolverEdgeToInterfaceWithNoImplementorsQuery {
+  resolver_field {
+    name
+  }
+}
+
+# %extensions%
+
+"""
+An interface with no implementors
+"""
+interface SomeInterface {
+  name: String
+}
+
+extend type Query {
+  resolver_field: SomeInterface
+    @relay_resolver(import_path: "./path/to/Resolver.js")
+}
+==================================== ERROR ====================================
+✖︎ Client Edges that reference client-defined interface types are not currently supported in Relay.
+
+  relay-resolver-edge-to-interface-with-no-implementors.graphql:3:3
+    2 │ query relayResolverEdgeToInterfaceWithNoImplementorsQuery {
+    3 │   resolver_field {
+      │   ^^^^^^^^^^^^^^
+    4 │     name
+
+
+✖︎ No types implement the client interface SomeInterface. Interfaces returned by a @RelayResolver must have at least one concrete implementation.
+
+  <generated>:2:35
+    1 │ # expected-to-throw
+    2 │ query relayResolverEdgeToInterfaceWithNoImplementorsQuery {
+      │                                   ^^^^^^^^^^^^^
+    3 │   resolver_field {
diff --git a/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.graphql b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.graphql
new file mode 100644
index 0000000000000..358021deb4e42
--- /dev/null
+++ b/compiler/crates/relay-compiler/tests/compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.graphql
@@ -0,0 +1,20 @@
+# expected-to-throw
+query relayResolverEdgeToInterfaceWithNoImplementorsQuery {
+  resolver_field {
+    name
+  }
+}
+
+# %extensions%
+
+"""
+An interface with no implementors
+"""
+interface SomeInterface {
+  name: String
+}
+
+extend type Query {
+  resolver_field: SomeInterface
+    @relay_resolver(import_path: "./path/to/Resolver.js")
+}
diff --git a/compiler/crates/relay-compiler/tests/compile_relay_artifacts_test.rs b/compiler/crates/relay-compiler/tests/compile_relay_artifacts_test.rs
index 6669a2d726067..df989150aae72 100644
--- a/compiler/crates/relay-compiler/tests/compile_relay_artifacts_test.rs
+++ b/compiler/crates/relay-compiler/tests/compile_relay_artifacts_test.rs
@@ -4,7 +4,7 @@
  * This source code is licensed under the MIT license found in the
  * LICENSE file in the root directory of this source tree.
  *
- * @generated SignedSource<<4c83edb5a97709b48ab136e569a1bc3e>>
+ * @generated SignedSource<<c12ec82876dcc0420715ee575dae6f2f>>
  */
 
 mod compile_relay_artifacts;
@@ -1104,6 +1104,20 @@ fn relay_resolver_backing_client_edge() {
     test_fixture(transform_fixture, "relay-resolver-backing-client-edge.graphql", "compile_relay_artifacts/fixtures/relay-resolver-backing-client-edge.expected", input, expected);
 }
 
+#[test]
+fn relay_resolver_edge_to_interface_with_child_interface_and_no_implementors() {
+    let input = include_str!("compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql");
+    let expected = include_str!("compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.expected");
+    test_fixture(transform_fixture, "relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.graphql", "compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-child-interface-and-no-implementors.expected", input, expected);
+}
+
+#[test]
+fn relay_resolver_edge_to_interface_with_no_implementors() {
+    let input = include_str!("compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.graphql");
+    let expected = include_str!("compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.expected");
+    test_fixture(transform_fixture, "relay-resolver-edge-to-interface-with-no-implementors.graphql", "compile_relay_artifacts/fixtures/relay-resolver-edge-to-interface-with-no-implementors.expected", input, expected);
+}
+
 #[test]
 fn relay_resolver_es_modules() {
     let input = include_str!("compile_relay_artifacts/fixtures/relay-resolver-es-modules.graphql");
diff --git a/compiler/crates/relay-transforms/src/client_edges.rs b/compiler/crates/relay-transforms/src/client_edges.rs
index a38759dfc9be4..1c4682c8ada56 100644
--- a/compiler/crates/relay-transforms/src/client_edges.rs
+++ b/compiler/crates/relay-transforms/src/client_edges.rs
@@ -363,7 +363,18 @@ impl<'program, 'sc> ClientEdgesTransform<'program, 'sc> {
             }
 
             match edge_to_type {
-                Type::Interface(_) => {
+                Type::Interface(interface_id) => {
+                    let interface = schema.interface(interface_id);
+                    let implementing_objects =
+                        interface.recursively_implementing_objects(Arc::as_ref(schema));
+                    if implementing_objects.is_empty() {
+                        self.errors.push(Diagnostic::error(
+                            ValidationMessage::RelayResolverClientInterfaceMustBeImplemented {
+                                interface_name: interface.name.item,
+                            },
+                            interface.name.location,
+                        ));
+                    }
                     if !has_output_type(resolver_directive) {
                         self.errors.push(Diagnostic::error(
                             ValidationMessage::ClientEdgeToClientInterface,
diff --git a/compiler/crates/relay-transforms/src/errors.rs b/compiler/crates/relay-transforms/src/errors.rs
index c99cb30c6ebf1..f93f1105094ee 100644
--- a/compiler/crates/relay-transforms/src/errors.rs
+++ b/compiler/crates/relay-transforms/src/errors.rs
@@ -168,7 +168,7 @@ pub enum ValidationMessage {
     },
 
     #[error(
-        "No types implement the client interface {interface_name}. For a client interface to be used as a @RelayResolver @outputType, at least one Object type must implement the interface."
+        "No types implement the client interface {interface_name}. Interfaces returned by a @RelayResolver must have at least one concrete implementation."
     )]
     RelayResolverClientInterfaceMustBeImplemented { interface_name: InterfaceName },
 
diff --git a/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.expected b/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.expected
index d7b9a7bb61baa..0507ac5f45373 100644
--- a/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.expected
+++ b/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.expected
@@ -16,6 +16,11 @@ interface ClientOnlyInterface implements Node {
   id: ID!
 }
 
+# Add a concrete type so that we don't trigger an unrelated compiler error.
+type BestFriend implements ClientOnlyInterface {
+  id: ID!
+}
+
 extend type User {
   best_friend: ClientOnlyInterface @relay_resolver(fragment_name: "BestFriendResolverFragment_name", import_path: "BestFriendResolver")
 }
diff --git a/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.graphql b/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.graphql
index 46c9dc032e4b3..9a3073baefde6 100644
--- a/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.graphql
+++ b/compiler/crates/relay-transforms/tests/client_edges/fixtures/client-edge-to-client-interface.invalid.graphql
@@ -15,6 +15,11 @@ interface ClientOnlyInterface implements Node {
   id: ID!
 }
 
+# Add a concrete type so that we don't trigger an unrelated compiler error.
+type BestFriend implements ClientOnlyInterface {
+  id: ID!
+}
+
 extend type User {
   best_friend: ClientOnlyInterface @relay_resolver(fragment_name: "BestFriendResolverFragment_name", import_path: "BestFriendResolver")
 }