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Use a 2-bit encoded reference #372

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marcelm opened this issue Nov 30, 2023 · 0 comments
Open

Use a 2-bit encoded reference #372

marcelm opened this issue Nov 30, 2023 · 0 comments

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@marcelm
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marcelm commented Nov 30, 2023

As discussed previously, we should try to switch to a 2-bit encoded reference to save memory. Any nucleotides that are not A, C, G, T would need to be mapped to a pseudo-randomly chosen nucleotide (as BWA does).
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