diff --git a/tcg/s390/tcg-target.c b/tcg/s390/tcg-target.c
index ee2e58d4daf..fbf97bb2e15 100644
--- a/tcg/s390/tcg-target.c
+++ b/tcg/s390/tcg-target.c
@@ -53,8 +53,6 @@
 
 #ifndef CONFIG_SOFTMMU
 #define TCG_GUEST_BASE_REG TCG_REG_R13
-#else
-#define TCG_GUEST_BASE_REG TCG_REG_R0
 #endif
 
 /* All of the following instructions are prefixed with their instruction
@@ -2344,10 +2342,12 @@ static void tcg_target_qemu_prologue(TCGContext *s)
                   TCG_STATIC_CALL_ARGS_SIZE + TCG_TARGET_CALL_STACK_OFFSET,
                   CPU_TEMP_BUF_NLONGS * sizeof(long));
 
+#ifndef CONFIG_SOFTMMU
     if (guest_base >= 0x80000) {
         tcg_out_movi(s, TCG_TYPE_PTR, TCG_GUEST_BASE_REG, guest_base);
         tcg_regset_set_reg(s->reserved_regs, TCG_GUEST_BASE_REG);
     }
+#endif
 
     tcg_out_mov(s, TCG_TYPE_PTR, TCG_AREG0, tcg_target_call_iarg_regs[0]);
     /* br %r3 (go to TB) */