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Primitive hematopoiesis is the first (transient) wave of emerging hematopoietic cells during embryonic development and generates predominantly primitive erythroid cells, macrophages and megakaryocytes within the blood islands in the yolk sac (Palis et al., 1999). Hematopoietic cells, including definitive hematopoietic stem cells (HSCs), with multi-lineage potential and capacity to engraft and reconstitute the blood system, emerge in the definitive wave of hematopoiesis, and originate from different sites within the embryo proper, including the ventral wall of the dorsal aorta within the aorta-gonad-mesonephros region (de Bruijn et al., 2002, Medvinsky and Dzierzak, 1996). Expression of endothelial markers on early hematopoietic cells demonstrates a direct link of hematopoietic and endothelial cells and a common endothelial progenitor (Bertrand et al., 2005, de Bruijn et al., 2002). Lineage-tracing studies provided further evidence for a specialized hemato-endothelial progenitor cell population (Zovein et al., 2009) that was broadly termed hemogenic endothelium (HE).
I am currently working on single-cell annotation of the publication here below:
PMID: 30787436 (2019)
"A single-cell molecular map of mouse gastrulation and early organogenesis"
At around E8.25, some endothelial cells (haemogenic endothelium) undergo an endothelial-to-haematopoietic transition and become Erythroid-Myeloid Progenitors (EMPs), which migrate to the foetal liver (FL) and give rise to definitive erythrocytes.
, and in order to capture this information, it seems that we need a new class 'hemogenic endothelium' ? and/or maybe better to ask CL for adding 'Haematoendothelial progenitors' ? see definition here below
def: "A specialized hemato-endothelial progenitor cell population that originates from mesodermal precursors with functional heterogeneity and distinct primitive and definitive hematopoietic capacities. By endothelial-to-hematopoietic transition (EHT), gives rise to hematopoietic cells."
Hello Team,
PMID: 31839543 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962646/
I am currently working on single-cell annotation of the publication here below:
PMID: 30787436 (2019)
"A single-cell molecular map of mouse gastrulation and early organogenesis"
, and in order to capture this information, it seems that we need a new class 'hemogenic endothelium' ? and/or maybe better to ask CL for adding 'Haematoendothelial progenitors' ? see definition here below
Preferred term label:
hemogenic endothelium
Synonyms
haemogenic endothelium (HE)
Definition (free text, please give PubMed ID)
PMID: 31839543
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962646/
def: "A specialized hemato-endothelial progenitor cell population that originates from mesodermal precursors with functional heterogeneity and distinct primitive and definitive hematopoietic capacities. By endothelial-to-hematopoietic transition (EHT), gives rise to hematopoietic cells."
Parent term (use https://www.ebi.ac.uk/ols/ontologies/uberon)
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0002050 ! embryonic structure
Thank you for your help and advice
Anne
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