diff --git a/CHANGELOG.md b/CHANGELOG.md
index 60a13ad70f..6e98fd24db 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -12,6 +12,7 @@ For experimental package changes, see the [experimental CHANGELOG](experimental/
 ### :rocket: (Enhancement)
 
 * feat(api): add `getActiveBaggage` API [#3385](https://github.com/open-telemetry/opentelemetry-js/pull/3385)
+* feat(instrumentation-grpc): set net.peer.name and net.peer.port on client spans [#3430](https://github.com/open-telemetry/opentelemetry-js/pull/3430)
 
 ### :bug: (Bug Fix)
 
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc-js/index.ts b/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc-js/index.ts
index 9473a17994..9147f455a0 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc-js/index.ts
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc-js/index.ts
@@ -49,7 +49,7 @@ import {
   getMetadata,
 } from './clientUtils';
 import { EventEmitter } from 'events';
-import { _extractMethodAndService, metadataCapture } from '../utils';
+import { _extractMethodAndService, metadataCapture, URI_REGEX } from '../utils';
 import { AttributeValues } from '../enums/AttributeValues';
 import { SemanticAttributes } from '@opentelemetry/semantic-conventions';
 
@@ -309,6 +309,18 @@ export class GrpcJsInstrumentation extends InstrumentationBase {
             [SemanticAttributes.RPC_METHOD]: method,
             [SemanticAttributes.RPC_SERVICE]: service,
           });
+        // set net.peer.* from target (e.g., "dns:otel-productcatalogservice:8080") as a hint to APMs
+        const parsedUri = URI_REGEX.exec(this.getChannel().getTarget());
+        if (parsedUri != null && parsedUri.groups != null) {
+          span.setAttribute(
+            SemanticAttributes.NET_PEER_NAME,
+            parsedUri.groups['name']
+          );
+          span.setAttribute(
+            SemanticAttributes.NET_PEER_PORT,
+            parseInt(parsedUri.groups['port'])
+          );
+        }
 
         instrumentation._metadataCapture.client.captureRequestMetadata(
           span,
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc/index.ts b/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc/index.ts
index dee3c9c3e3..436e04ada4 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc/index.ts
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/src/grpc/index.ts
@@ -45,6 +45,7 @@ import {
   _extractMethodAndService,
   _methodIsIgnored,
   metadataCapture,
+  URI_REGEX,
 } from '../utils';
 import { SemanticAttributes } from '@opentelemetry/semantic-conventions';
 import { AttributeValues } from '../enums/AttributeValues';
@@ -321,6 +322,18 @@ export class GrpcNativeInstrumentation extends InstrumentationBase<
             [SemanticAttributes.RPC_METHOD]: method,
             [SemanticAttributes.RPC_SERVICE]: service,
           });
+        // set net.peer.* from target (e.g., "dns:otel-productcatalogservice:8080") as a hint to APMs
+        const parsedUri = URI_REGEX.exec(this.getChannel().getTarget());
+        if (parsedUri != null && parsedUri.groups != null) {
+          span.setAttribute(
+            SemanticAttributes.NET_PEER_NAME,
+            parsedUri.groups['name']
+          );
+          span.setAttribute(
+            SemanticAttributes.NET_PEER_PORT,
+            parseInt(parsedUri.groups['port'])
+          );
+        }
 
         instrumentation._metadataCapture.client.captureRequestMetadata(
           span,
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/src/utils.ts b/experimental/packages/opentelemetry-instrumentation-grpc/src/utils.ts
index 473cc920a1..8d031107dd 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/src/utils.ts
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/src/utils.ts
@@ -19,6 +19,10 @@ import type * as grpcTypes from 'grpc';
 import type * as grpcJsTypes from '@grpc/grpc-js';
 import { IgnoreMatcher } from './types';
 
+// e.g., "dns:otel-productcatalogservice:8080" or "otel-productcatalogservice:8080" or "127.0.0.1:8080"
+export const URI_REGEX =
+  /(?:([A-Za-z0-9+.-]+):(?:\/\/)?)?(?<name>[A-Za-z0-9+.-]+):(?<port>[0-9+.-]+)$/;
+
 // Equivalent to lodash _.findIndex
 export const findIndex: <T>(args: T[], fn: (arg: T) => boolean) => number = (
   args,
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/test/helper.ts b/experimental/packages/opentelemetry-instrumentation-grpc/test/helper.ts
index 5b16525a5d..85b6a1c64e 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/test/helper.ts
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/test/helper.ts
@@ -515,6 +515,8 @@ export const runTests = (
       const validations = {
         name: `grpc.pkg_test.GrpcTester/${methodName}`,
         status: grpc.status.OK,
+        netPeerName: 'localhost',
+        netPeerPort: grpcPort,
       };
 
       assertSpan(moduleName, serverSpan, SpanKind.SERVER, validations);
@@ -699,6 +701,8 @@ export const runTests = (
             const validations = {
               name: `grpc.pkg_test.GrpcTester/${method.methodName}`,
               status: errorCode,
+              netPeerName: 'localhost',
+              netPeerPort: grpcPort,
             };
             const serverRoot = spans[0];
             const clientRoot = spans[1];
@@ -738,6 +742,8 @@ export const runTests = (
               const validations = {
                 name: `grpc.pkg_test.GrpcTester/${method.methodName}`,
                 status: errorCode,
+                netPeerName: 'localhost',
+                netPeerPort: grpcPort,
               };
               assertSpan(moduleName, serverSpan, SpanKind.SERVER, validations);
               assertSpan(moduleName, clientSpan, SpanKind.CLIENT, validations);
diff --git a/experimental/packages/opentelemetry-instrumentation-grpc/test/utils/assertionUtils.ts b/experimental/packages/opentelemetry-instrumentation-grpc/test/utils/assertionUtils.ts
index 64ed00df76..24d4bf7af8 100644
--- a/experimental/packages/opentelemetry-instrumentation-grpc/test/utils/assertionUtils.ts
+++ b/experimental/packages/opentelemetry-instrumentation-grpc/test/utils/assertionUtils.ts
@@ -38,7 +38,12 @@ export const assertSpan = (
   component: string,
   span: ReadableSpan,
   kind: SpanKind,
-  validations: { name: string; status: grpc.status | grpcJs.status }
+  validations: {
+    name: string;
+    status: grpc.status | grpcJs.status;
+    netPeerName?: string;
+    netPeerPort?: number;
+  }
 ) => {
   assert.strictEqual(span.spanContext().traceId.length, 32);
   assert.strictEqual(span.spanContext().spanId.length, 16);
@@ -56,6 +61,21 @@ export const assertSpan = (
     assert.ok(span.spanContext());
   }
 
+  if (
+    span.kind === SpanKind.CLIENT &&
+    validations.netPeerName !== undefined &&
+    validations.netPeerPort !== undefined
+  ) {
+    assert.strictEqual(
+      span.attributes[SemanticAttributes.NET_PEER_NAME],
+      validations.netPeerName
+    );
+    assert.strictEqual(
+      span.attributes[SemanticAttributes.NET_PEER_PORT],
+      validations.netPeerPort
+    );
+  }
+
   // validations
   assert.strictEqual(span.name, validations.name);
   assert.strictEqual(