diff --git a/pkg/executor/distsql_test.go b/pkg/executor/distsql_test.go
index c883b178d1eb3..42c4531925e67 100644
--- a/pkg/executor/distsql_test.go
+++ b/pkg/executor/distsql_test.go
@@ -698,3 +698,25 @@ func TestIndexLookUpWithSelectForUpdateOnPartitionTable(t *testing.T) {
 	tk.MustHavePlan("select b from t use index(k) where b > 2 order by b limit 1 for update", "IndexLookUp")
 	tk.MustQuery("select b from t use index(k) where b > 2 order by b limit 1 for update").Check(testkit.Rows("3"))
 }
+
+func TestCoprCacheWithoutExecutionInfo(t *testing.T) {
+	store := testkit.CreateMockStore(t)
+	tk := testkit.NewTestKit(t, store)
+	tk1 := testkit.NewTestKit(t, store)
+	tk.MustExec("use test")
+	tk.MustExec("drop table if exists t")
+	tk.MustExec("create table t(id int)")
+	tk.MustExec("insert into t values(1), (2), (3)")
+
+	require.NoError(t, failpoint.Enable("github.com/pingcap/tidb/pkg/store/mockstore/unistore/cophandler/mockCopCacheInUnistore", `return(123)`))
+	defer func() {
+		require.NoError(t, failpoint.Disable("github.com/pingcap/tidb/pkg/store/mockstore/unistore/cophandler/mockCopCacheInUnistore"))
+	}()
+
+	defer tk.MustExec("set @@tidb_enable_collect_execution_info=1")
+	ctx := context.WithValue(context.Background(), "CheckSelectRequestHook", func(_ *kv.Request) {
+		tk1.MustExec("set @@tidb_enable_collect_execution_info=0")
+	})
+	tk.MustQuery("select * from t").Check(testkit.Rows("1", "2", "3"))
+	tk.MustQueryWithContext(ctx, "select * from t").Check(testkit.Rows("1", "2", "3"))
+}
diff --git a/pkg/store/copr/coprocessor.go b/pkg/store/copr/coprocessor.go
index 770b6a3dd6546..184d714fd52c3 100644
--- a/pkg/store/copr/coprocessor.go
+++ b/pkg/store/copr/coprocessor.go
@@ -1685,7 +1685,14 @@ func (worker *copIteratorWorker) handleCopCache(task *copTask, resp *copResponse
 				resp.pbResp.Range = nil
 			}
 		}
-		resp.detail.CoprCacheHit = true
+		// `worker.enableCollectExecutionInfo` is loaded from the instance's config. Because it's not related to the request,
+		// the cache key can be same when `worker.enableCollectExecutionInfo` is true or false.
+		// When `worker.enableCollectExecutionInfo` is false, the `resp.detail` is nil, and hit cache is still possible.
+		// Check `resp.detail` to avoid panic.
+		// Details: https://github.com/pingcap/tidb/issues/48212
+		if resp.detail != nil {
+			resp.detail.CoprCacheHit = true
+		}
 		return nil
 	}
 	copr_metrics.CoprCacheCounterMiss.Add(1)