diff --git a/docs/changes/492.misc.rst b/docs/changes/492.misc.rst
new file mode 100644
index 00000000..fcb58ba5
--- /dev/null
+++ b/docs/changes/492.misc.rst
@@ -0,0 +1 @@
+PEP 621: Migrate from setup.cfg to pyproject.toml
diff --git a/pyproject.toml b/pyproject.toml
index 1b5842da..7836bebb 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,7 +1,70 @@
 [build-system]
-requires = ["setuptools>=46.4.0"]
+requires = ["setuptools>=61.2"]
 build-backend = "setuptools.build_meta"
 
+[project]
+name = "sphinx-autoapi"
+authors = [{name = "Eric Holscher", email = "eric@ericholscher.com"}]
+maintainers = [{name = "Ashley Whetter", email = "ashley@awhetter.co.uk"}]
+description = "Sphinx API documentation generator"
+license = {text = "MIT"}
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Environment :: Plugins",
+    "Framework :: Sphinx :: Extension",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: MIT License",
+    "Natural Language :: English",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3.11",
+]
+requires-python = ">=3.8"
+dependencies = [
+    'astroid>=2.7;python_version<"3.12"',
+    'astroid>=3.0.0a1;python_version>="3.12"',
+    "Jinja2",
+    "PyYAML",
+    "sphinx>=6.1.0,<8.1.0",
+    'stdlib_list;python_version<"3.10"',
+]
+dynamic = ["version"]
+
+[project.readme]
+file = "README.rst"
+content-type = "text/x-rst"
+
+[project.urls]
+Homepage = "http://github.com/readthedocs/sphinx-autoapi"
+Documentation = "https://sphinx-autoapi.readthedocs.io/en/latest/"
+
+[project.optional-dependencies]
+docs = [
+    "furo",
+    "sphinx",
+    "sphinx_design",
+]
+
+[tool.setuptools]
+include-package-data = true
+license-files = ["LICENSE.rst"]
+
+[tool.setuptools.packages.find]
+include = [
+    "autoapi",
+    "autoapi.*",
+]
+namespaces = false
+
+[tool.setuptools.dynamic]
+version = {attr = "autoapi.__version__"}
+
+[tool.distutils.bdist_wheel]
+universal = 1
+
 [tool.mypy]
 # Start off with these
 warn_unused_configs = true
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 9f8cb2d8..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,55 +0,0 @@
-[metadata]
-name = sphinx-autoapi
-version = attr: autoapi.__version__
-author = Eric Holscher
-author_email = eric@ericholscher.com
-maintainer = Ashley Whetter
-maintainer_email = ashley@awhetter.co.uk
-description = Sphinx API documentation generator
-long_description = file: README.rst
-long_description_content_type = text/x-rst
-url = http://github.com/readthedocs/sphinx-autoapi
-license = MIT
-license_files =
-    LICENSE.rst
-classifiers =
-    Development Status :: 4 - Beta
-    Environment :: Plugins
-    Framework :: Sphinx :: Extension
-    Intended Audience :: Developers
-    License :: OSI Approved :: MIT License
-    Natural Language :: English
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.8
-    Programming Language :: Python :: 3.9
-    Programming Language :: Python :: 3.10
-    Programming Language :: Python :: 3.11
-project_urls =
-    Documentation = https://sphinx-autoapi.readthedocs.io/en/latest/
-
-[options]
-packages = find:
-include_package_data = True
-python_requires = >=3.8
-install_requires =
-    astroid>=2.7;python_version<"3.12"
-    astroid>=3.0.0a1;python_version>="3.12"
-    Jinja2
-    PyYAML
-    sphinx>=6.1.0
-    stdlib_list;python_version<"3.10"
-
-[options.extras_require]
-docs =
-    furo
-    sphinx
-    sphinx_design
-
-[options.packages.find]
-include =
-    autoapi
-    autoapi.*
-
-[bdist_wheel]
-universal = 1
diff --git a/tests/python/pyexample/example/example.py b/tests/python/pyexample/example/example.py
index 4f88de68..3dc7f5e5 100644
--- a/tests/python/pyexample/example/example.py
+++ b/tests/python/pyexample/example/example.py
@@ -169,7 +169,7 @@ def fn_with_long_sig(
     signature,
     many,
     keyword,
-    arguments
+    arguments,
 ):
     """A function with a long signature."""