diff --git a/Cargo.lock b/Cargo.lock
index 16aed3dc49ca0..91a6ebe4446a4 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -3673,6 +3673,7 @@ dependencies = [
  "rustc_macros",
  "rustc_metadata",
  "rustc_middle",
+ "rustc_monomorphize",
  "rustc_query_system",
  "rustc_serialize",
  "rustc_session",
diff --git a/compiler/rustc_codegen_cranelift/src/abi/mod.rs b/compiler/rustc_codegen_cranelift/src/abi/mod.rs
index 6e846d721f2e2..b33587f8948b9 100644
--- a/compiler/rustc_codegen_cranelift/src/abi/mod.rs
+++ b/compiler/rustc_codegen_cranelift/src/abi/mod.rs
@@ -8,8 +8,11 @@ use std::borrow::Cow;
 
 use cranelift_codegen::ir::SigRef;
 use cranelift_module::ModuleError;
+use rustc_codegen_ssa::errors::CompilerBuiltinsCannotCall;
 use rustc_middle::middle::codegen_fn_attrs::CodegenFnAttrFlags;
 use rustc_middle::ty::layout::FnAbiOf;
+use rustc_middle::ty::print::with_no_trimmed_paths;
+use rustc_monomorphize::is_call_from_compiler_builtins_to_upstream_monomorphization;
 use rustc_session::Session;
 use rustc_span::source_map::Spanned;
 use rustc_target::abi::call::{Conv, FnAbi};
@@ -372,6 +375,17 @@ pub(crate) fn codegen_terminator_call<'tcx>(
             ty::Instance::expect_resolve(fx.tcx, ty::ParamEnv::reveal_all(), def_id, fn_args)
                 .polymorphize(fx.tcx);
 
+        if is_call_from_compiler_builtins_to_upstream_monomorphization(fx.tcx, instance) {
+            if target.is_some() {
+                let caller = with_no_trimmed_paths!(fx.tcx.def_path_str(fx.instance.def_id()));
+                let callee = with_no_trimmed_paths!(fx.tcx.def_path_str(def_id));
+                fx.tcx.dcx().emit_err(CompilerBuiltinsCannotCall { caller, callee });
+            } else {
+                fx.bcx.ins().trap(TrapCode::User(0));
+                return;
+            }
+        }
+
         if fx.tcx.symbol_name(instance).name.starts_with("llvm.") {
             crate::intrinsics::codegen_llvm_intrinsic_call(
                 fx,
diff --git a/compiler/rustc_codegen_cranelift/src/base.rs b/compiler/rustc_codegen_cranelift/src/base.rs
index 2415c2c90b22c..047dc56a32ead 100644
--- a/compiler/rustc_codegen_cranelift/src/base.rs
+++ b/compiler/rustc_codegen_cranelift/src/base.rs
@@ -8,6 +8,7 @@ use rustc_index::IndexVec;
 use rustc_middle::ty::adjustment::PointerCoercion;
 use rustc_middle::ty::layout::FnAbiOf;
 use rustc_middle::ty::print::with_no_trimmed_paths;
+use rustc_monomorphize::is_call_from_compiler_builtins_to_upstream_monomorphization;
 
 use crate::constant::ConstantCx;
 use crate::debuginfo::FunctionDebugContext;
@@ -999,6 +1000,12 @@ fn codegen_panic_inner<'tcx>(
     let def_id = fx.tcx.require_lang_item(lang_item, span);
 
     let instance = Instance::mono(fx.tcx, def_id).polymorphize(fx.tcx);
+
+    if is_call_from_compiler_builtins_to_upstream_monomorphization(fx.tcx, instance) {
+        fx.bcx.ins().trap(TrapCode::User(0));
+        return;
+    }
+
     let symbol_name = fx.tcx.symbol_name(instance).name;
 
     fx.lib_call(
diff --git a/compiler/rustc_codegen_cranelift/src/lib.rs b/compiler/rustc_codegen_cranelift/src/lib.rs
index 7e2e1f7c6ac07..a59a39074f8c0 100644
--- a/compiler/rustc_codegen_cranelift/src/lib.rs
+++ b/compiler/rustc_codegen_cranelift/src/lib.rs
@@ -21,6 +21,7 @@ extern crate rustc_hir;
 extern crate rustc_incremental;
 extern crate rustc_index;
 extern crate rustc_metadata;
+extern crate rustc_monomorphize;
 extern crate rustc_session;
 extern crate rustc_span;
 extern crate rustc_target;
diff --git a/compiler/rustc_codegen_ssa/Cargo.toml b/compiler/rustc_codegen_ssa/Cargo.toml
index 7851b9e8e038c..baf10622a6df6 100644
--- a/compiler/rustc_codegen_ssa/Cargo.toml
+++ b/compiler/rustc_codegen_ssa/Cargo.toml
@@ -25,6 +25,7 @@ rustc_index = { path = "../rustc_index" }
 rustc_macros = { path = "../rustc_macros" }
 rustc_metadata = { path = "../rustc_metadata" }
 rustc_middle = { path = "../rustc_middle" }
+rustc_monomorphize = { path = "../rustc_monomorphize" }
 rustc_query_system = { path = "../rustc_query_system" }
 rustc_serialize = { path = "../rustc_serialize" }
 rustc_session = { path = "../rustc_session" }
diff --git a/compiler/rustc_codegen_ssa/messages.ftl b/compiler/rustc_codegen_ssa/messages.ftl
index 5ba66d1be4329..d159fe58d3eef 100644
--- a/compiler/rustc_codegen_ssa/messages.ftl
+++ b/compiler/rustc_codegen_ssa/messages.ftl
@@ -16,6 +16,9 @@ codegen_ssa_cgu_not_recorded =
 
 codegen_ssa_check_installed_visual_studio = please ensure that Visual Studio 2017 or later, or Build Tools for Visual Studio were installed with the Visual C++ option.
 
+codegen_ssa_compiler_builtins_cannot_call =
+    `compiler_builtins` cannot call functions through upstream monomorphizations; encountered invalid call from `{$caller}` to `{$callee}`
+
 codegen_ssa_copy_path = could not copy {$from} to {$to}: {$error}
 
 codegen_ssa_copy_path_buf = unable to copy {$source_file} to {$output_path}: {$error}
diff --git a/compiler/rustc_codegen_ssa/src/common.rs b/compiler/rustc_codegen_ssa/src/common.rs
index 44a2434238dad..71fca403defb5 100644
--- a/compiler/rustc_codegen_ssa/src/common.rs
+++ b/compiler/rustc_codegen_ssa/src/common.rs
@@ -2,6 +2,7 @@
 
 use rustc_hir::LangItem;
 use rustc_middle::mir;
+use rustc_middle::ty::Instance;
 use rustc_middle::ty::{self, layout::TyAndLayout, Ty, TyCtxt};
 use rustc_span::Span;
 
@@ -120,11 +121,11 @@ pub fn build_langcall<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
     bx: &Bx,
     span: Option<Span>,
     li: LangItem,
-) -> (Bx::FnAbiOfResult, Bx::Value) {
+) -> (Bx::FnAbiOfResult, Bx::Value, Instance<'tcx>) {
     let tcx = bx.tcx();
     let def_id = tcx.require_lang_item(li, span);
     let instance = ty::Instance::mono(tcx, def_id);
-    (bx.fn_abi_of_instance(instance, ty::List::empty()), bx.get_fn_addr(instance))
+    (bx.fn_abi_of_instance(instance, ty::List::empty()), bx.get_fn_addr(instance), instance)
 }
 
 // To avoid UB from LLVM, these two functions mask RHS with an
diff --git a/compiler/rustc_codegen_ssa/src/errors.rs b/compiler/rustc_codegen_ssa/src/errors.rs
index 3572ee301c818..b843d1bdf2350 100644
--- a/compiler/rustc_codegen_ssa/src/errors.rs
+++ b/compiler/rustc_codegen_ssa/src/errors.rs
@@ -1030,3 +1030,10 @@ pub struct FailedToGetLayout<'tcx> {
 pub struct ErrorCreatingRemarkDir {
     pub error: std::io::Error,
 }
+
+#[derive(Diagnostic)]
+#[diag(codegen_ssa_compiler_builtins_cannot_call)]
+pub struct CompilerBuiltinsCannotCall {
+    pub caller: String,
+    pub callee: String,
+}
diff --git a/compiler/rustc_codegen_ssa/src/mir/block.rs b/compiler/rustc_codegen_ssa/src/mir/block.rs
index 9bb2a52826585..09286a8ed24ba 100644
--- a/compiler/rustc_codegen_ssa/src/mir/block.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/block.rs
@@ -5,6 +5,7 @@ use super::{CachedLlbb, FunctionCx, LocalRef};
 
 use crate::base;
 use crate::common::{self, IntPredicate};
+use crate::errors::CompilerBuiltinsCannotCall;
 use crate::meth;
 use crate::traits::*;
 use crate::MemFlags;
@@ -16,6 +17,7 @@ use rustc_middle::mir::{self, AssertKind, BasicBlock, SwitchTargets, UnwindTermi
 use rustc_middle::ty::layout::{HasTyCtxt, LayoutOf, ValidityRequirement};
 use rustc_middle::ty::print::{with_no_trimmed_paths, with_no_visible_paths};
 use rustc_middle::ty::{self, Instance, Ty};
+use rustc_monomorphize::is_call_from_compiler_builtins_to_upstream_monomorphization;
 use rustc_session::config::OptLevel;
 use rustc_span::{source_map::Spanned, sym, Span};
 use rustc_target::abi::call::{ArgAbi, FnAbi, PassMode, Reg};
@@ -157,8 +159,28 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
         destination: Option<(ReturnDest<'tcx, Bx::Value>, mir::BasicBlock)>,
         mut unwind: mir::UnwindAction,
         copied_constant_arguments: &[PlaceRef<'tcx, <Bx as BackendTypes>::Value>],
+        instance: Option<Instance<'tcx>>,
         mergeable_succ: bool,
     ) -> MergingSucc {
+        let tcx = bx.tcx();
+        if let Some(instance) = instance {
+            if is_call_from_compiler_builtins_to_upstream_monomorphization(tcx, instance) {
+                if destination.is_some() {
+                    let caller = with_no_trimmed_paths!(tcx.def_path_str(fx.instance.def_id()));
+                    let callee = with_no_trimmed_paths!(tcx.def_path_str(instance.def_id()));
+                    tcx.dcx().emit_err(CompilerBuiltinsCannotCall { caller, callee });
+                } else {
+                    info!(
+                        "compiler_builtins call to diverging function {:?} replaced with abort",
+                        instance.def_id()
+                    );
+                    bx.abort();
+                    bx.unreachable();
+                    return MergingSucc::False;
+                }
+            }
+        }
+
         // If there is a cleanup block and the function we're calling can unwind, then
         // do an invoke, otherwise do a call.
         let fn_ty = bx.fn_decl_backend_type(fn_abi);
@@ -480,6 +502,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         let ty = location.ty(self.mir, bx.tcx()).ty;
         let ty = self.monomorphize(ty);
         let drop_fn = Instance::resolve_drop_in_place(bx.tcx(), ty);
+        let instance = drop_fn.clone();
 
         if let ty::InstanceDef::DropGlue(_, None) = drop_fn.def {
             // we don't actually need to drop anything.
@@ -582,6 +605,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             Some((ReturnDest::Nothing, target)),
             unwind,
             &[],
+            Some(instance),
             mergeable_succ,
         )
     }
@@ -658,10 +682,11 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             }
         };
 
-        let (fn_abi, llfn) = common::build_langcall(bx, Some(span), lang_item);
+        let (fn_abi, llfn, instance) = common::build_langcall(bx, Some(span), lang_item);
 
         // Codegen the actual panic invoke/call.
-        let merging_succ = helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], false);
+        let merging_succ =
+            helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], Some(instance), false);
         assert_eq!(merging_succ, MergingSucc::False);
         MergingSucc::False
     }
@@ -677,7 +702,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         self.set_debug_loc(bx, terminator.source_info);
 
         // Obtain the panic entry point.
-        let (fn_abi, llfn) = common::build_langcall(bx, Some(span), reason.lang_item());
+        let (fn_abi, llfn, instance) = common::build_langcall(bx, Some(span), reason.lang_item());
 
         // Codegen the actual panic invoke/call.
         let merging_succ = helper.do_call(
@@ -689,6 +714,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             None,
             mir::UnwindAction::Unreachable,
             &[],
+            Some(instance),
             false,
         );
         assert_eq!(merging_succ, MergingSucc::False);
@@ -738,7 +764,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                 let msg = bx.const_str(&msg_str);
 
                 // Obtain the panic entry point.
-                let (fn_abi, llfn) =
+                let (fn_abi, llfn, instance) =
                     common::build_langcall(bx, Some(source_info.span), LangItem::PanicNounwind);
 
                 // Codegen the actual panic invoke/call.
@@ -751,6 +777,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                     target.as_ref().map(|bb| (ReturnDest::Nothing, *bb)),
                     unwind,
                     &[],
+                    Some(instance),
                     mergeable_succ,
                 )
             } else {
@@ -798,6 +825,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             ty::FnPtr(_) => (None, Some(callee.immediate())),
             _ => bug!("{} is not callable", callee.layout.ty),
         };
+
         let def = instance.map(|i| i.def);
 
         if let Some(ty::InstanceDef::DropGlue(_, None)) = def {
@@ -1106,6 +1134,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             destination,
             unwind,
             &copied_constant_arguments,
+            instance,
             mergeable_succ,
         )
     }
@@ -1664,7 +1693,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
 
         self.set_debug_loc(&mut bx, mir::SourceInfo::outermost(self.mir.span));
 
-        let (fn_abi, fn_ptr) = common::build_langcall(&bx, None, reason.lang_item());
+        let (fn_abi, fn_ptr, _instance) = common::build_langcall(&bx, None, reason.lang_item());
         let fn_ty = bx.fn_decl_backend_type(fn_abi);
 
         let llret = bx.call(fn_ty, None, Some(fn_abi), fn_ptr, &[], funclet.as_ref());
diff --git a/compiler/rustc_codegen_ssa/src/size_of_val.rs b/compiler/rustc_codegen_ssa/src/size_of_val.rs
index 087836ca37de0..e2e95cede60a5 100644
--- a/compiler/rustc_codegen_ssa/src/size_of_val.rs
+++ b/compiler/rustc_codegen_ssa/src/size_of_val.rs
@@ -62,7 +62,8 @@ pub fn size_and_align_of_dst<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
             let msg = bx.const_str(&msg_str);
 
             // Obtain the panic entry point.
-            let (fn_abi, llfn) = common::build_langcall(bx, None, LangItem::PanicNounwind);
+            let (fn_abi, llfn, _instance) =
+                common::build_langcall(bx, None, LangItem::PanicNounwind);
 
             // Generate the call.
             // Cannot use `do_call` since we don't have a MIR terminator so we can't create a `TerminationCodegenHelper`.
diff --git a/compiler/rustc_monomorphize/src/collector.rs b/compiler/rustc_monomorphize/src/collector.rs
index cd9eb4916ce5d..cf4a62a5edfef 100644
--- a/compiler/rustc_monomorphize/src/collector.rs
+++ b/compiler/rustc_monomorphize/src/collector.rs
@@ -1020,7 +1020,7 @@ fn visit_instance_use<'tcx>(
 
 /// Returns `true` if we should codegen an instance in the local crate, or returns `false` if we
 /// can just link to the upstream crate and therefore don't need a mono item.
-fn should_codegen_locally<'tcx>(tcx: TyCtxt<'tcx>, instance: &Instance<'tcx>) -> bool {
+pub(crate) fn should_codegen_locally<'tcx>(tcx: TyCtxt<'tcx>, instance: &Instance<'tcx>) -> bool {
     let Some(def_id) = instance.def.def_id_if_not_guaranteed_local_codegen() else {
         return true;
     };
diff --git a/compiler/rustc_monomorphize/src/lib.rs b/compiler/rustc_monomorphize/src/lib.rs
index 7f36ae91f1a03..6de545416438f 100644
--- a/compiler/rustc_monomorphize/src/lib.rs
+++ b/compiler/rustc_monomorphize/src/lib.rs
@@ -11,7 +11,10 @@ use rustc_hir::lang_items::LangItem;
 use rustc_middle::query::{Providers, TyCtxtAt};
 use rustc_middle::traits;
 use rustc_middle::ty::adjustment::CustomCoerceUnsized;
+use rustc_middle::ty::Instance;
+use rustc_middle::ty::TyCtxt;
 use rustc_middle::ty::{self, Ty};
+use rustc_span::def_id::LOCAL_CRATE;
 use rustc_span::ErrorGuaranteed;
 
 mod collector;
@@ -20,6 +23,8 @@ mod partitioning;
 mod polymorphize;
 mod util;
 
+use collector::should_codegen_locally;
+
 rustc_fluent_macro::fluent_messages! { "../messages.ftl" }
 
 fn custom_coerce_unsize_info<'tcx>(
@@ -45,6 +50,22 @@ fn custom_coerce_unsize_info<'tcx>(
     }
 }
 
+/// Returns whether a call from the current crate to the [`Instance`] would produce a call
+/// from `compiler_builtins` to a symbol the linker must resolve.
+///
+/// Such calls from `compiler_bultins` are effectively impossible for the linker to handle. Some
+/// linkers will optimize such that dead calls to unresolved symbols are not an error, but this is
+/// not guaranteed. So we used this function in codegen backends to ensure we do not generate any
+/// unlinkable calls.
+pub fn is_call_from_compiler_builtins_to_upstream_monomorphization<'tcx>(
+    tcx: TyCtxt<'tcx>,
+    instance: Instance<'tcx>,
+) -> bool {
+    !instance.def_id().is_local()
+        && tcx.is_compiler_builtins(LOCAL_CRATE)
+        && !should_codegen_locally(tcx, &instance)
+}
+
 pub fn provide(providers: &mut Providers) {
     partitioning::provide(providers);
     polymorphize::provide(providers);