test_sent

Furthermore
,
when
all
deliveries
were
analyzed
,
regardless
of
risk
status
but
limited
to
gestational
age
>
or
=
36
weeks
,
the
rates
did
not
change
(
12.6
%
,
280
of
2214
;
primary
9.2
%
,
183
of
1994
)

As
the
ambient
temperature
increases
,
there
is
an
increase
in
insensible
fluid
loss
and
the
potential
for
dehydration

The
daily
high
temperature
ranged
from
71
to
104
degrees
F
and
AFI
values
ranged
from
1.7
to
24.7
cm
during
the
study
period

There
was
a
significant
correlation
between
the
2-
,
3-
,
and
4-day
mean
temperature
and
AFI
,
with
the
4-day
mean
being
the
most
significant
(
r
=
0.31
,
p
&
#
60
;
0.001
)

Fluctuations
in
ambient
temperature
are
inversely
correlated
to
changes
in
AFI

This
study
tested
the
hypothesis
that
to
reduce
the
rate
of
macrosomic
infants
in
gestational
diabetes
cases
,
good
glycemic
control
should
be
initiated
before
34
completed
gestational
weeks

In
the
``
early
''
and
``
late
''
groups
,
mean
gestational
age
at
the
beginning
of
treatment
was
30.0
+/-
3.8
and
36.2
+/-
1.2
weeks
,
and
duration
of
treatment
was
9.6
+/-
4.1
and
3.7
+/-
1.8
weeks
,
respectively

The
rate
of
macrosomic
and
large-for-gestational-age
infants
were
5
and
11
%
,
respectively
,
in
the
early
group
as
compared
to
25
and
29
%
in
the
``
late
''
group
(
p
&
#
60
;
0.05
)

In
our
study
,
we
specifically
analyzed
the
role
played
by
advanced
maternal
age
and
sonographically
discovered
abnormalities
in
the
detection
of
autosomal
trisomies

All
together
,
27
fetuses
had
this
disorder
,
representing
28.7
%
(
27
of
94
)
of
all
cytogenetic
aberrations
detected
at
our
center
over
the
same
period

The
most
common
indication
leading
to
diagnosis
was
abnormal
ultrasound
finding
(
48.2
%
)
,
followed
by
advanced
maternal
age
(
44.4
%
)

However
,
63
%
of
the
trisomic
fetuses
belonged
to
mothers
aged
35
years
and
above

Trisomy
18
fetuses
showed
hydramnios
,
intrauterine
growth
retardation
,
microcephaly
,
spina
bifida
,
and
nonimmune
hydrops
fetalis

The
objective
of
this
study
was
to
determine
if
the
rate
of
preeclampsia
is
increased
in
triplet
as
compared
to
twin
gestations

These
were
matched
for
maternal
age
,
parity
,
and
race
to
twin
gestations
(
N
=
53
)
from
the
same
population

The
rate
of
severe
preeclampsia
was
increased
significantly
in
the
triplet
group
12
of
53
(
22.6
%
)
as
compared
with
the
twin
group
3
of
53
(
5.7
%
)
(
OR
=
4.9
,
95
%
CI
1.2-23.5
,
p
=
0.02
)

We
conducted
a
survey
and
audit
of
thermal
equipment
use
in
very
low-birth-weight
infants
in
five
Ohio
neonatal
intensive
care
units
(
NICUs
)
to
document
regional
practice

The
infant
presented
with
extreme
pallor
,
hypotonia
,
hepatosplenomegaly
,
and
ascites

The
initial
hemoglobin
was
2.2
g/dL
,
the
Kleihauer-Betke
stain
was
27.6
%
(
highest
level
ever
reported
)

Right
temporal
and
cerebellar
hemorrhages
were
present

Sequelae
include
severe
developmental
delay
and
asymmetric
double
hemiplegia

A
subchorial
placental
hematoma
,
which
detected
as
a
subchorial
placental
lucencies
by
ultrasonography
,
can
be
a
cause
of
reversible
nonimmune
hydrops
fetalis

SETTING
:
Clinic
populations
in
the
continental
United
States

Sibpair
analysis
(
n=54
)
resulted
in
maximum
lod
scores
(
MLSs
)
of
1.5
,
2.6
,
3.2
,
and
2.3
for
these
markers
,
with
a
peak
multipoint
MLS
of
3.5

A
priori
stratification
by
APOE
genotype
identified
27
families
that
had
at
least
1
member
with
AD
whose
genotype
did
not
contain
an
APOE*4
allele

CONCLUSIONS
:
A
complete
genomic
screen
in
families
affected
with
late-onset
AD
identified
4
regions
of
interest
after
follow-up

Chromosome
12
gave
the
strongest
and
most
consistent
results
with
a
peak
multipoint
MLS
of
3.5
,
suggesting
that
this
region
contains
a
new
susceptibility
gene
for
AD

CONTEXT
:
A
mutation
in
the
BRCA1
gene
may
confer
substantial
risk
for
breast
and/or
ovarian
cancer

DESIGN
:
A
complete
sequence
analysis
of
the
BRCA1
coding
sequence
and
flanking
intronic
regions
was
performed
in
798
women
in
a
collaborative
effort
involving
institutions
from
the
United
States
,
Italy
,
Germany
,
Finland
,
and
Switzerland

PARTICIPANTS
:
Institutions
selected
798
persons
representing
families
(
1
person
for
each
family
)
thought
to
be
at
elevated
a
priori
risk
of
BRCA1
mutation
due
to
potential
risk
factors
,
such
as
multiple
cases
of
breast
cancer
,
early
age
of
breast
cancer
diagnosis
,
and
cases
of
ovarian
cancer

RESULTS
:
In
102
women
(
12.8
%
)
,
clearly
deleterious
mutations
were
detected

In
a
subset
of
71
Ashkenazi
Jewish
women
,
only
2
distinct
deleterious
mutations
were
found
:
185delAG
in
17
cases
and
5382insC
in
7
cases

CONCLUSIONS
:
Using
logistic
regression
analysis
,
we
provide
a
method
for
evaluating
the
probability
of
a
woman
's
carrying
a
deleterious
BRCA1
mutation
for
a
wide
range
of
cases
,
which
can
be
an
important
tool
for
clinicians
as
they
incorporate
genetic
susceptibility
testing
into
their
medical
practice

CONTEXT
:
Approximately
9
%
of
prostate
cancer
cases
have
been
estimated
to
result
from
inheritance
of
mutated
prostate
cancer
susceptibility
genes

Few
data
exist
as
to
whether
there
are
clinical
differences
between
prostate
cancers
that
are
inherited
and
those
that
occur
in
the
general
population

DESIGN
:
Retrospective
case
study
in
which
clinical
data
were
extracted
from
medical
and
pathological
records

FAMILIES
:
A
total
of
74
North
American
families
with
hereditary
prostate
cancer

CONCLUSIONS
:
Families
that
provide
evidence
for
segregation
of
an
altered
HPC1
gene
are
characterized
by
multiple
cases
of
prostate
cancer
that
,
in
most
respects
,
are
indistinguishable
from
nonhereditary
cases

However
,
except
for
genes
in
the
HLA
system
,
specific
susceptibility
loci
are
unknown
or
unconfirmed

OBJECTIVE
:
To
investigate
several
loci
spanning
3
candidate
regions
for
a
role
in
multiple
sclerosis
(
MS
)
susceptibility
in
2
ethnic
groups
using
both
single-locus
and
haplotype
analyses

DESIGN
:
Case-control
association
testing

Variation
within
the
MBP
locus
on
chromosome
18q23
showed
no
effect
in
MS

D19S574
showed
a
significant
effect
(
P=.015
)
in
Caucasian
patients
with
MS
due
to
the
increased
frequency
of
a
single
allele
(
P=.002
)

Interaction
effects
between
DR2
and
chromosome
19q13.2
or
MBP
in
MS
susceptibility
were
not
apparent

CONCLUSIONS
:
The
significant
chromosome
19q13.2
single-locus
and
multilocus
haplotype
associations
with
MS
in
Caucasian
and
Chinese
patient
samples
indicate
an
effect
from
a
nearby
disease
susceptibility
locus

These
initial
observations
are
an
encouraging
step
toward
the
description
of
non-HLA
genetic
susceptibility
to
MS

<
TO_SEE
>
CONTEXT
:
There
is
a
substantial
risk
of
a
second
cancer
for
persons
with
hereditary
retinoblastoma
,
which
is
enhanced
by
radiotherapy

A
radiation
risk
for
all
sarcomas
combined
was
evident
at
doses
above
5
Gy
,
rising
to
10.7-fold
at
doses
of
60
Gy
or
greater
(
P
&
#
60
;
.05
)

The
urine
screen
did
not
influence
management
decisions

Demographic
information
,
hours
from
rupture
of
membranes
to
delivery
,
gestational
age
,
and
birth
weight
at
delivery
were
compared
using
Fisher
's
exact
,
Mann-Whitney
U
,
and
randomization
tests
where
appropriate

Women
in
the
cocaine
positive
group
were
of
higher
parity
(
3
,
(
0-7
)
vs.
1
,
(
0-6
)
,
p
=
0.001
)
and
tended
to
be
older
(
27
,
(
23-42
)
vs.
25
,
(
14-40
)
)

Cocaine-positive
women
presented
at
an
earlier
gestational
age
(
32
weeks
'
,
(
24-34
)
vs.
33
weeks
'
,
(
23-36
)
,
p
=
0.02
)
and
had
a
significantly
longer
membrane
rupture
to
delivery
interval
than
women
with
a
negative
urine
drug
screen
(
174
hr
,
(
6-475
)
vs.
33
hours
(
1-833
)
,
p
=
0.01
)

The
objective
of
this
article
is
to
explore
attitudes
of
an
inner-city
,
pregnant
cohort
about
general
and
HIV-related
prenatal
care

However
,
the
association
of
parvovirus
and
fetal
pleural
or
pericardial
effusions
has
not
been
reported

In
the
absence
of
structural
or
karyotypic
abnormalities
,
spontaneous
resolution
of
the
effusion
portends
for
a
successful
pregnancy
outcome

Results
of
early
rehabilitation
seem
to
be
influenced
by
duration
and
etiology
of
deafness
,
experience
with
hearing
aids
,
and
other
factors

Signals
have
qualitative
and
quantitative
aspects

Type
C
effects
(
those
effects
related
to
an
increased
frequency
of
'spontaneous
'
disease
)
are
difficult
to
study
,
however
,
and
continue
to
pose
a
pharmacoepidemiological
challenge

Seven
basic
considerations
can
be
identified
that
determine
the
evidence
contained
in
a
signal
:
quantitative
strength
of
the
association
,
consistency
of
the
data
,
exposure
response
relationship
,
biological
plausibility
,
experimental
findings
,
possible
analogies
and
the
nature
and
quality
of
the
data

A
double-blind
,
crossover
design
was
used
to
compare
the
effects
of
methylphenidate
versus
placebo
on
an
electroencephalogram
,
AED
levels
,
and
the
CPT

There
were
no
significant
changes
in
AED
levels
or
electroencephalographic
findings

CONCLUSION
:
Methylphenidate
is
effective
in
treating
children
with
epilepsy
and
ADHD
and
safe
in
children
who
are
seizure
free

An
LRP
was
only
observed
on
no-go
trials
when
the
semantic
(
not
the
phonological
)
decision
determined
the
response
hand

These
results
provide
electrophysiological
evidence
for
early
semantic
activation
and
later
phonological
encoding

The
effects
of
alanine
and
glycine
substitution
for
tryptophan
upon
the
species
heterogeneity
of
gramicidin
A
analogs
incorporated
into
SDS
micelles
have
been
investigated

An
increase
in
the
SDS
concentration
reduces
the
number
of
different
species
present
in
micelles

In
the
case
of
the
12
base-pair
DNA
duplex
,
torsion-angle
molecular
dynamics
had
a
success
rate
of
52
%
while
Cartesian
molecular
dynamics
and
metric-matrix
distance
geometry
always
failed

They
have
been
combined
with
a
nonlinear
regression
analysis
method
and
tested
on
both
simulated
and
real
sets
of
biomedical
MRS
data
selected
with
respect
to
the
main
problems
usually
encountered
in
quantifying
biomedical
MRS
,
specifically
``
chemical
noise
,
''
resulting
from
overlapping
resonances
,
and
baseline
distortion

At
293
sites
,
we
randomly
assigned
8803
patients
who
had
had
myocardial
infarction
,
treatment
with
160
mg
aspirin
,
3
mg
warfarin
with
80
mg
aspirin
,
or
1
mg
warfarin
with
80
mg
aspirin

1-year
life-table
estimates
for
the
primary
event
were
8.6
%
(
95
%
CI
7.6-9.6
)
for
160
mg
aspirin
,
8.4
%
(
7.4-9.4
)
for
3
mg
warfarin
with
80
mg
aspirin
,
and
8.8
%
(
7.6-10
)
for
1
mg
warfarin
with
80
mg
aspirin

For
spontaneous
major
haemorrhage
(
not
procedure
related
)
,
1-year
life-table
estimates
were
0.74
%
(
0.43-1.1
)
in
the
160
mg
aspirin
group
and
1.4
%
(
0.94-1.8
)
in
the
3
mg
warfarin
with
80
mg
aspirin
group
(
p
=
0.014
log
rank
on
follow-up
)

METHODS
:
The
effect
of
roxithromycin
was
assessed
in
a
double-blind
,
randomised
,
prospective
,
multicentre
,
parallel-group
,
placebo-controlled
pilot
study
of
202
patients
with
unstable
angina
or
non-Q-wave
myocardial
infarction

The
treatment
was
for
30
days

INTERPRETATION
:
Antichlamydial
antibiotics
may
be
useful
in
therapeutic
intervention
in
addition
to
standard
medication
in
patients
with
coronary-artery
disease

343
eligible
patients
were
randomised
:
172
to
surgery
and
171
to
radical
radiotherapy

INTERPRETATION
:
There
is
no
treatment
of
choice
for
early-stage
cervical
carcinoma
in
terms
of
overall
or
disease-free
survival

This
article
discusses
many
of
the
nutritional
topics
important
to
the
intensivist

Nutritional
assessment
,
substrate
immunonutrition
,
and
disease
specific
issues
are
presented

These
levels
were
determined
in
patients
undergoing
three
types
of
therapy
:
non-in
vitro
fertilization
(
IVF
)
,
IVF-embryo
transfer
(
ET
)
,
and
frozen
ET

Sera
were
drawn
12
days
from
ovulation
in
non-IVF
cycles
or
9
days
after
ET
and
were
assayed
for
PIBF
and
beta
human
chorionic
gondotropin

Comparison
of
the
frequency
of
lymphocyte
expression
of
PIBF
in
pregnant
versus
non-pregnant
women
were
made

RESULTS
:
PIBF
was
detected
in
29.5
%
of
non-pregnant
women
and
52.5
%
of
pregnant
women

It
is
generally
assumed
that
abiotic
synthesis
of
amino
acids
on
the
early
Earth
resulted
in
racemic
mixtures
(
L-
and
D-enantiomers
in
equal
abundance
)

But
the
origin
of
life
required
,
owing
to
conformational
constraints
,
the
almost
exclusive
selection
of
either
L-
or
D-enantiomers
,
and
the
question
of
why
living
systems
on
the
Earth
consist
of
L-enantiomers
rather
than
D-enantiomers
is
unresolved

Here
we
show
that
individual
amino-acid
enantiomers
from
Murchison
are
enriched
in
15N
relative
to
their
terrestrial
counterparts
,
so
confirming
an
extraterrestrial
source
for
an
L-enantiomer
excess
in
the
Solar
System
that
may
predate
the
origin
of
life
on
the
Earth

Home
care
workers
face
an
increasing
risk
for
workplace
violence

Miracidia
clearly
preferred
SCW
from
their
specific
host
snail
versus
other
sympatric
snail
species
and
did
not
respond
to
water
conditioned
with
fish
,
tadpoles
,
or
leeches

After
adjusting
for
stage
,
factors
such
as
poverty
,
other
socioeconomic
conditions
,
and
treatment
did
not
further
explain
the
remaining
survival
deficit

This
study
examined
the
aggressiveness
of
colon
tumors
in
blacks
and
whites
to
explore
its
role
in
the
racial
survival
differences

Similar
B/W
differences
were
observed
for
patients
with
advanced
disease
but
not
with
early
stage

A
key
feature
of
the
method
is
isolation
and
reverse
transcription
of
mRNA
followed
by
PCR
amplification
of
lysosomal
alpha-glucosidase
cDNA
with
M13-extended
primers

Dye
labeled
primers
are
used
for
cycle
sequencing
and
an
ABI
PRISM
377
DNA
sequencing
system
for
analysis

The
advantages
and
pitfalls
of
this
new
method
are
discussed
in
the
light
of
the
results
obtained
with
an
infantile
GSDII
patient

Very
few
autonomic
tests
have
been
done
on
pediatric
patients
thus
far

Twenty-four
patients
with
cerebral
palsy
and
24
control
subjects
between
the
ages
of
4
and
12
yr
were
enrolled
in
this
study

There
was
no
significant
difference
of
mean
latency
,
amplitude
,
or
amplitude
ratio
of
SSR
between
the
two
groups
under
electric
stimulus
,
startling
stimulus
,
and
deep
breathing
conditions

College
students
spend
4
hr
weekly
on
the
PM
&
#
38
;
R
consultation
service
as
team
members
under
resident
supervision

The
rehabilitation
consultation
service
is
particularly
effective
as
an
introduction
to
hospital-based
medical
practice
due
to
the
diagnostic
variety
of
the
patients
,
the
functional
approach
of
rehabilitation
,
and
student
exposure
to
multiple
hospital
settings

The
Biopsychosocial
Model
of
medical
practice
is
demonstrated
through
multiple
interdisciplinary
perspectives
of
needs
and
interventions
for
patients
with
obvious
functional
deficits

The
involved
upper
trapezius
muscles
were
treated
with
three
different
methods
according
to
a
random
assignment
:
group
A
muscles
(
n
=
18
)
were
given
placebo
treatment
(
control
group
)
;
group
B
muscles
(
n
=
20
)
were
treated
with
electrical
nerve
stimulation
(
ENS
)
therapy
;
and
group
C
muscles
(
n
=
22
)
were
given
electrical
muscle
stimulation
(
EMS
)
therapy

The
effectiveness
of
treatment
was
assessed
by
conducting
three
measurements
on
each
muscle
before
and
immediately
after
treatment
:
subjective
pain
intensity
(
(
PI
)
with
a
visual
analog
scale
)
,
pressure
pain
threshold
(
(
PT
)
with
algometry
)
,
and
range
of
motion
(
(
ROM
)
with
a
goniometer
)
of
upper
trapezius
muscle
(
lateral
bending
of
cervical
spine
to
the
opposite
side
)

When
the
effectiveness
of
treatment
was
compared
with
that
of
the
placebo
group
(
group
A
)
,
there
was
significant
improvement
in
PI
and
PT
in
group
B
(
P
&
#
60
;
0.01
)
but
not
in
group
C
(
P
>
0.05
)

When
each
group
was
divided
into
two
additional
subgroups
based
on
the
initial
PI
,
it
was
found
that
ENS
could
reduce
PI
and
increase
PT
significantly
(
P
&
#
60
;
0.05
)
,
but
did
not
significantly
(
P
>
0.05
)
improve
ROM
,
as
compared
with
the
placebo
group
for
both
subgroups

It
could
reduce
PI
significantly
more
(
P
&
#
60
;
0.05
)
than
placebo
controls
only
for
the
subgroup
with
mild
to
moderate
pain
,
but
not
with
severe
pain

For
pain
relief
,
ENS
was
significantly
better
(
P
&
#
60
;
0.05
)
than
EMS
;
but
for
the
improvement
of
ROM
,
EMS
was
significantly
better
(
P
&
#
60
;
0.05
)
than
ENS

It
is
concluded
that
ENS
is
more
effective
for
immediate
relief
of
myofascial
trigger
point
pain
than
EMS
,
and
EMS
has
a
better
effect
on
immediate
release
of
muscle
tightness
than
ENS

The
mean
training
time
per
week
was
3.2
+/-
0.8
h.
In
the
entire
group
of
female
dancers
,
no
significant
effects
of
dancing
on
radial
or
lumbar
bone
density
could
be
observed

For
additional
evaluation
,
females
were
divided
into
two
subgroups
,
osteoporotic
or
nonosteoporotic
,
based
on
x-rays
and
lumbar
bone
mineral
density
(
BMD
)
as
measured
by
qCT

DESIGN
:
Cross
sectional
survey

RESULTS
:
Prevalence
of
confirmed
infection
was
2.6
%
(
95
%
confidence
interval
1.6
%
to
3.6
%
)
in
all
women

Prevalence
on
the
basis
of
enzyme
immunoassay
was
1.6
%
(
0.8
%
to
2.7
%
)
,
with
a
sensitivity
of
60
%
and
a
specificity
of
100
%

Screening
all
women
aged
&
#
60
;
or
=
25
and
all
women
who
had
had
two
or
more
partners
in
the
past
year
would
have
detected
87
%
(
20/23
)
of
infections

It
offers
potential
as
a
non-invasive
screening
tool

This
clinical
commentary
discusses
the
current
management
of
the
syndrome
including
the
Abbe-McIndoe
procedure
,
the
most
commonly
used
method
of
surgical
correction
,
and
the
Frank
vaginal
dilation
method
,
the
most
common
nonsurgical
method
of
correction

OBJECTIVES
:
Obesity
is
an
important
clinical
problem
,
and
the
use
of
dexfenfluramine
hydrochloride
for
weight
reduction
has
been
widely
publicized
since
its
approval
by
the
Food
and
Drug
Administration

Our
purpose
was
to
systematically
review
data
on
brain
serotonin
neurotoxicity
in
animals
treated
with
fenfluramines
and
the
evidence
linking
fenfluramines
to
primary
pulmonary
hypertension
(
PPH
)

Appetite
suppressants-most
commonly
fenfluramines
-increase
the
risk
of
developing
PPH
(
odds
ratio
,
6.3
)
,
particularly
when
used
for
more
than
3
months
(
odds
ratio
,
>
20
)

It
is
not
known
if
such
damage
occurs
in
humans
or
if
there
are
clinical
consequences

Future
studies
should
address
the
long-term
consequences
of
prolonged
use
of
fenfluramines

The
manufacturer
claims
that
moxonidine
``
accurately
targets
imidazoline
receptors
at
the
cardiovascular
control
centre
in
the
brainstem
''
and
is
``
as
effective
as
current
first-line
therapies
for
essential
hypertension
``

This
article
discusses
dental
anxiety
and
phobia

The
author
presents
background
information
,
including
incidence
and
etiology

The
article
stresses
behavioral
treatment
modalities
that
eliminate
the
debilitating
phobia

The
effect
was
most
pronounced
in
the
central
part
of
the
treated
area
,
where
no
positive
fox
was
found
in
the
2
months
before
the
end
of
the
trial

The
study
was
controlled
for
other
factors
that
could
influence
the
parasite
's
prevalence
,
such
as
the
availability
of
intermediate
hosts

multilocularis
from
wild
hosts
has
been
demonstrated
,
the
question
of
its
long-term
efficacy
and
other
unresolved
problems
have
to
be
addressed
by
consecutive
studies
before
routine
application
can
be
recommended

In
contrast
,
purified
primary
normal
progenitors
maintained
under
the
same
conditions
die
rapidly

In
fact
,
time
course
studies
demonstrated
an
even
faster
onset
of
apoptosis
in
ceramide-treated
BCR-ABL+
BAF3
cells
as
compared
to
normal
controls

BCR-ABL+
cells
treated
with
ceramide
also
showed
a
rapid
and
sequential
increase
in
the
tyrosine
phosphorylation
of
p210
(
BCR-ABL
)
,
p46-56SHC
and
p120Cbl

These
findings
suggest
growth
factor
deprivation
and
treatment
with
TNF-alpha
or
ceramide
trigger
different
initial
events
both
of
which
can
lead
to
apoptosis
in
factor-dependent
hematopoietic
cells

Here
we
show
that
the
medial
temporal
region
is
active
during
encoding
and
that
the
hemisphere
activated
and
the
amount
of
activation
depend
on
the
type
of
stimulus
presented
(
objects
or
words
)
,
whether
the
stimulus
can
be
encoded
for
meaning
(
real
objects
and
words
versus
nonsense
objects
and
words
)
,
and
task
experience
(
first
versus
the
second
time
a
task
is
performed
)

Transiently
evolked
otoacoustic
emissions
(
TEOAE
)
have
been
reported
in
several
studies
as
absent
in
a
small
minority
of
normal
ears

In
order
to
understand
and
model
cochlear
processes
involved
in
TEOAE
generation
,
it
needs
to
be
known
whether
the
presence
of
normal
hearing
leads
automatically
to
generation
of
TEOAEs

The
present
study
set
out
to
establish
in
a
large
sample
if
any
ears
could
be
found
that
lacked
TEOAEs
despite
normal
hearing
threshold
levels
(
HTL
)

However
,
careful
visual
assessment
of
the
recorded
waveforms
for
the
remaining
ears
did
not
unequivocally
show
absence
of
TEOAE
characteristics
in
any
ear
with
normal
HTLs

The
function
of
the
short
form
was
examined
after
cotransfection
of
both
the
long
and
short
forms

These
results
clearly
show
that
the
short
form
acts
as
a
dominant
negative
inhibitor
through
the
formation
of
inactive
heterodimers
,
resulting
in
an
inhibition
of
Janus
kinase
2
(
JAK2
)
activation

The
present
study
also
investigates
the
possible
participation
of
cytoplasmic
receptors
in
the
signal
transduction
pathway
,
using
cotransfection
experiments
and
a
new
approach
that
selectively
determines
the
contribution
of
cytoplasmic
receptors
in
the
process
of
signal
transduction

This
partial
recovery
is
also
parallel
to
the
partial
activation
of
JAK2
,
indicating
that
the
signal
transduction
pathway
implicated
JAK2

BACKGROUND
:
Inadequate
dietary
intake
of
calcium
and
vitamin
D
may
contribute
to
the
high
prevalence
of
osteoporosis
among
older
persons

All
hand
instruments
,
handpieces
and
triplex
syringes
were
autoclaved
between
patients

The
human
DNA
mismatch
repair
(
MMR
)
genes
are
highly
conserved
homologues
of
the
Escherichia
coli
MutHLS
system
,
which
contribute
to
genomic
stability
by
surveillance
and
repair
of
replication
misincorporation
errors
and
exogenous
DNA
damage

Synergism
in
tumorigenesis
and
independent
segregation
of
the
MSI
phenotype
suggest
that
Msh2
and
p53
are
not
genetically
epistatic

Curtis
,
Radiat

106
,
252-270
,
1986
)
and
double-strand
break
(
DSB
)
(
J

However
,
some
recovery
was
seen
for
a
change
in
the
medium
(
growth
medium
to
conditioned
medium
)
up
to
5-6
h
postirradiation

Reanalysis
of
the
original
data
on
DSB
repair
shows
that
they
are
consistent
with
two
first-order
repair
rates
(
18
+/-
7
min
and
about
52
min
)

These
results
are
consistent
with
two
pools
of
DSBs
(
or
cells
)
,
each
with
their
own
t
(
rep
)

DESIGN
:
Randomized
controlled
trial

PARTICIPANTS
:
The
562
participating
adolescents
represented
92
%
of
students
in
mandatory
classes

INTERVENTION
:
After
random
assignment
to
1
of
3
groups
,
the
adolescents
listened
to
a
standardized
audiotape
depiction
of
an
office
visit
during
which
they
heard
a
physician
who
assured
unconditional
confidentiality
,
a
physician
who
assured
conditional
confidentiality
,
or
a
physician
who
did
not
mention
confidentiality

Granulocyte-colony
stimulating
factor
(
G-CSF
)
increases
the
release
of
neutrophils
from
the
bone
marrow
and
improves
neutrophil
function

METHODS
:
40
diabetic
patients
with
foot
infections
were
enrolled
in
a
double-blind
placebo-controlled
study

On
admission
,
patients
were
randomly
assigned
G-CSF
(
filgrastim
)
therapy
(
n
=
20
)
or
placebo
(
n
=
20
)
for
7
days

Neutrophils
from
the
peripheral
blood
of
these
participants
and
from
healthy
controls
were
stimulated
with
opsonised
zymosan
,
and
superoxide
production
was
measured
by
a
spectrophotometric
assay
(
reduction
of
ferricytochrome
C
)

<
TO_SEE
>
FINDINGS
:
G-CSF
therapy
was
associated
with
earlier
eradication
of
pathogens
from
the
infected
ulcer
(
median
4
(
range
2-10
)
vs
8
(
2-79
)
days
in
the
placebo
group
;
p
=
0.02
)
,
quicker
resolution
of
cellulitis
<
(
7
(
5-20
)
vs
12
(
5-93
)
days
;
p
=
0.03
)
,
shorter
hospital
stay
(
10
(
7-31
)
vs
17.5
(
9-100
)
days
;
p
=
0.02
)
,
and
a
shorter
duration
of
intravenous
antibiotic
treatment
(
8.5
(
5-30
)
vs
14.5
(
8-63
)
days
;
p
=
0.02
)

After
7
days
'
treatment
,
neutrophil
superoxide
production
was
significantly
higher
in
the
G-CSF
group
than
in
the
placebo
group
(
16.1
(
4.2-24.2
)
vs
7.3
(
2.1-11.5
)
nmol
per
10
(
6
)
neutrophils
in
30
min
;
p
&
#
60
;
0.0001
)

INTERPRETATION
:
G-CSF
treatment
was
associated
with
improved
clinical
outcome
of
foot
infection
in
diabetic
patients

The
absolute
difference
was
0.44
percent
,
with
a
one-sided
95
percent
upper
boundary
of
1.49
percent
,
which
exceeded
the
prespecified
upper
limit
of
0.40
percent
to
indicate
equivalence
in
30-day
mortality
between
the
two
regimens

The
respective
rates
of
any
stroke
and
of
hemorrhagic
stroke
were
1.92
and
1.12
percent
after
double-bolus
alteplase
,
as
compared
with
1.53
and
0.81
percent
after
an
accelerated
infusion
of
alteplase
(
P=0.24
and
P=0.23
,
respectively
)

CONCLUSIONS
:
Double-bolus
alteplase
was
not
shown
to
be
equivalent
,
according
to
the
prespecified
criteria
,
to
accelerated
infusion
with
regard
to
30-day
mortality

There
was
also
a
slightly
higher
rate
of
intracranial
hemorrhage
with
the
double-bolus
method

<
TO_SEE
>
METHODS
:
We
identified
valvular
heart
diseasein
24
women
treated
with
fenfluramine-phentermine
who
had
no
history
of
cardiac
disease

Both
right-sided
and
left-sided
heart
valves
were
involved

Eight
women
also
had
newly
documented
pulmonary
hypertension

The
heart
valves
had
a
glistening
white
appearance

Histopathological
findings
included
plaque-like
encasement
of
the
leaflets
and
chordal
structures
with
intact
valve
architecture

Successful
arthrodesis
was
achieved
in
all
five
feet
in
patients
with
rheumatoid
arthritis

Subjectively
,
patients
improved
from
an
average
of
0.69
before
arthrodesis
to
4.89
after
arthrodesis

The
patient
's
ability
to
wear
shoes
improved
from
0.87
to
3.1

Hallux
length
was
well
maintained
after
surgery
with
bone
grafting
,
but
it
was
more
difficult
to
obtain
the
alignment
goals

The
average
postoperative
metatarsophalangeal
dorsiflexion
angle
was
15.6
degrees
and
the
first
metatarsophalangeal
angle
was
3.1
degrees

OBJECTIVE
:
To
estimate
the
crude
incidence
rates
of
cerebrovascular
accidents
among
the
black
residents
of
Harare

PARTICIPANTS
:
Two
hundred
and
seventy-three
'first-ever
'
strokes
prospectively
identified
over
a
12-month
period

MAIN
OUTCOME
STUDY
FACTORS
:
Cerebrovascular
accident
first-week
fatality
rate
;
age-
and
sex-related
incidence

Fifty-one
per
cent
of
stroke
victims
were
below
the
age
of
54
years

Thirty-five
per
cent
of
patients
died
within
1
week
of
the
stroke

Overall
,
the
age-specific
rates
for
both
sexes
rose
with
age
,
with
the
rates
for
women
being
higher
at
all
age
strata
except
for
the
group
45-54
years

MAIN
OUTCOME
MEASURES
:
Mean
blood
pressure
and
rate
of
high
blood
pressure
of
children

CONCLUSION
:
Calcium
supplementation
during
pregnancy
is
associated
with
lower
systolic
blood
pressure
in
the
offspring
,
particularly
among
overweight
children

The
addition
of
peroxynitrite
to
CO2
produces
of
the
adduct
ONOO-CO2-
(
1
)

The
production
of
1
greatly
accelerates
the
decomposition
of
peroxynitrite
to
give
nitrate

Primary
efficacy
endpoint
was
the
percentage
improvement
in
Unified
Parkinson
's
Disease
Rating
Scale
(
UPDRS
)
motor
score

Ropinirole-treated
patients
had
a
significantly
greater
percentage
improvement
in
UPDRS
motor
score
than
patients
who
received
placebo
(
+24
%
vs
-3
%
;
p
&
#
60
;
0.001
)

Most
adverse
experiences
were
related
to
peripheral
dopaminergic
activity

Ropinirole
monotherapy
is
an
effective
and
well-tolerated
therapeutic
option
for
treatment
of
early
Parkinson
's
disease

In
the
present
study
,
parthenogenotes
were
obtained
by
the
activation
of
immature
oocytes
with
caffeine
before
treatment
with
1-methyladenine
(
1-MeAde
)
to
induce
oocyte
maturation

These
results
indicate
that
the
present
parthenogenesis
mechanism
shares
the
same
characteristics
as
that
achieved
by
post-GVBD
activation
in
the
suppression
of
polar
body
formation
as
a
key
means
for
successful
starfish
parthenogenesis

Fluoride
increased
the
vertebral
BV/TV
by
35
%
(
P
&
#
60
;
0.05
)
and
tibial
ash
weight
by
10
%
(
P
&
#
60
;
0.05
)

High-dose
fluoride
treatment
did
not
improve
,
but
decreased
,
bone
strength
in
rabbits
,
even
in
the
absence
of
impaired
mineralization

SETTING
:
Cullen
Eye
Institute
,
Baylor
College
of
Medicine
,
Houston
,
Texas
,
USA

Evidence
for
the
presence
of
a
serotonin1A
(
5-HT1A
)
receptor
subtype
in
the
salmonid
fish
brain
has
recently
been
presented

RESULTS
:
Mean
follow
up
time
was
similar
(
antibiotic
group
1.07
years
,
other
two
groups
1.03
years
)

More
of
those
initially
prescribed
antibiotics
initially
returned
to
the
surgery
with
sore
throat
(
38
%
v
27
%
,
adjusted
hazard
ratio
for
return
1.39
%
,
95
%
confidence
interval
1.03
to
1.89
)

Antibiotics
prescribed
for
sore
throat
during
the
previous
year
had
an
additional
effect
(
hazard
ratio
1.69
,
1.20
to
2.37
)

Longer
duration
of
illness
(
>
5
days
)
was
associated
with
increased
return
within
six
weeks
(
hazard
ratio
2.90
,
1.70
to
4.92
)

Prior
attendance
with
upper
respiratory
conditions
was
also
associated
with
increased
reattendance

There
was
no
difference
between
groups
in
early
return
(
13/238
(
5.5
%
)
v
27/437
(
6
%
)
)
,
or
complications
(
2/236
(
0.8
%
)
v
3/434
(
0.7
%
)
)

Both
current
and
previous
prescribing
for
sore
throat
increase
reattendance

This
study
was
designed
to
determine
and
compare
the
dose-response
characteristics
,
speed
of
onset
,
and
relative
potency
of
single-dose
epidural
fentanyl
(
F
)
and
sufentanil
(
S
)
for
postoperative
pain
relief

The
study
was
terminated
at
30
min
if
satisfactory
analgesia
was
not
achieved

Side
effects
were
recorded

A
dose-response
was
demonstrated
for
both
opioids

F
100
and
200
microg
and
S
20
and
30
microg
all
achieved
VAS
scores
&
#
60
;
10
mm
in
all
women
with
no
differences
in
time
to
50
%
reduction
in
VAS
(
mean
11-16
min
)
and
no
differences
in
duration
of
analgesia
(
mean
117-138
min
)

There
were
no
differences
among
groups
in
sedation
scores
or
side
effects

Our
data
suggest
that
the
relative
analgesic
potency
of
epidural
S
:
F
is
approximately
5
and
that
there
are
no
differences
between
the
opioids
in
the
onset
,
duration
,
and
effectiveness
of
analgesia
when
equianalgesic
doses
are
administered
postoperatively
after
lidocaine
anesthesia
for
C/S

Transesophageal
echocardiography
demonstrated
aliasing
on
color
flow
mapping
in
the
left
main
coronary
artery
in
1
case
and
proximal
right
coronary
artery
in
the
other
,
along
with
severely
depressed
left
ventricular
anterior
wall
and
right
ventricular
function
,
respectively

In
patients
with
chronic
neutropenia
,
splenomegaly
has
been
described
with
long-term
use
,
and
extramedullary
hematopoiesis
has
also
been
reported

<
TO_SEE
>
Every
effort
must
be
made
to
exclude
abdominal
tuberculosis
before
the
patient
is
diagnosed
as
having
Crohn
's
disease
and
is
treated
with
steroids

PURPOSE
:
The
American
Urological
Association
convened
the
Female
Stress
Urinary
Incontinence
Clinical
Guidelines
Panel
to
analyze
the
literature
regarding
surgical
procedures
for
treating
stress
urinary
incontinence
in
the
otherwise
healthy
female
subject
and
to
make
practice
recommendations
based
on
the
treatment
outcomes
data

MATERIALS
AND
METHODS
:
The
panel
searched
the
MEDLINE
data
base
for
all
articles
through
1993
on
surgical
treatment
of
female
stress
urinary
incontinence

Outcomes
data
were
extracted
from
articles
accepted
after
panel
review

The
evidence
supports
surgery
as
initial
therapy
and
as
a
secondary
form
of
therapy
after
failure
of
other
treatments
for
stress
urinary
incontinence

This
did
not
increase
with
an
infusion
of
30
mcg/kg
per
min
of
dobutamine
,
which
resulted
in
an
increase
in
the
cardiac
output
from
1.96
to
5.46
l/min

BACKGROUND
:
For
more
than
30
years
it
has
been
known
that
gastric
acid
secretion
is
inversely
related
to
the
extent
and
severity
of
corpal
gastritis

METHODS
:
Basal
acid
output
(
BAO
)
and
maximal
acid
output
(
MAO
)
were
assessed
in
11
H.
pylori-infected
dyspeptic
patients
(
8
women
and
3
men
;
mean
age
,
28
years
)
before
and
after
successful
anti-H

pylori
therapy

We
hypothesize
that
there
is
a
higher
incidence
of
preeclampsia
(
proteinuric
hypertension
)
in
women
conceiving
by
intrauterine
insemination
with
donor
sperm
versus
intrauterine
insemination
with
partner
sperm

Three
cases
of
mild
preeclampsia
were
found
in
the
partner
insemination
program
and
nine
cases
of
preeclampsia
(
five
severe
,
four
mild
)
in
the
donor
insemination
program
(
relative
risk
1.85
,
95
%
confidence
interval
1.20
to
2.85
)
.

The
antigenic
factor
would
appear
to
be
located
on
the
sperm
as
opposed
to
the
seminal
fluid
itself

Radical
reactions
can
cause
mutations
,
inactivation
or
a
decrease
in
the
turnover
of
mitochondrial
DNA
which
is
more
vulnerable
than
the
nuclear
genoma
to
the
attack
of
mutagenic
agents
,
acting
also
as
a
continuous
source
of
initial
and/or
promoting
factors
of
the
carcinogenetic
process

The
somatic
cells
become
senescent
because
during
cell
division
,
they
lose
the
mechanisms
for
the
lengthening
of
the
telomere

Switch
substrate
retrovectors
(
SSR
)
contain
a
long-terminal
repeat-driven
neomycin
(
Neo
)
gene
for
proviral
chromosomal
maintenance
(
pre-
and
post-S
recombination
)
and
a
CMV
promoter-driven
,
chimeric
hygromycin-thymidine
kinase
(
Hytk
)
gene
(
flanked
by
S
mu
and
S
gamma
2b
recombination
targets
)
to
select
for
(
ganciclovir
)
and
against
(
hygromycin
B
)
S
region
recombination

The
retro-substrates
'
strong
,
constitutive
promoters
ensure
that
variations
in
cellular
switch
recombinase
activities
are
independent
of
S
region
accessibility
control

SETTING
:
A
collaborative
study
between
the
Rotunda
Hospital
,
Dublin
and
the
Irish
National
Drug
Advisory
&
#
38
;
Treatment
Centre

The
pre-
and
postnatal
prevalence
of
abuse
was
matched
with
demographic
data

RESULTS
:
The
prevalence
of
chemical
substance
misuse
in
the
antenatal
population
was
2.8
%
and
5.6
%
in
the
postnatal
population

Cloacal
anomalies
are
extremely
rare
and
have
variable
presentations

OBJECTIVE
:
To
determine
whether
patients
with
myocardial
amyloidosis
due
either
to
AL
(
primary
)
amyloid
or
familial
amyloid
have
distinguishing
echocardiographic
or
electrocardiographic
features
;
and
to
compare
the
prevalence
of
heart
failure
and
survival
in
the
two
types
of
amyloidosis
in
relation
to
echocardiographic
findings

PATIENTS
:
36
patients
with
cardiac
amyloid
heart
disease
,
of
whom
12
had
familial
and
24
had
primary
AL
amyloidosis

Retinopathy
was
assessed
by
ophthalmoscopy
after
pupillary
dilation
and
classified
as
any
retinopathy
or
as
nonproliferative
and
proliferative

Diagnostic
peritoneal
lavage
is
an
easily
performed
and
inexpensive
test
that
may
be
useful
in
this
situation

Intra-abdominal
injury
was
present
in
32
(
73
%
)
of
these
patients

The
senior
surgery
resident
correctly
predicted
the
presence
of
intra-abdominal
injury
in
36
(
82
%
)
of
the
patients
(
sensitivity
=
90.0
%
,
specificity
=
58.3
%
,
positive
predictive
value
=
85.3
%
,
negative
predictive
value
=
63.6
%
,
phi
=
0.52
,
P
&
#
60
;
.01
)
in
the
emergency
department
before
DPL
and
celiotomy
were
performed

CONCLUSIONS
:
Clinical
judgment
is
highly
accurate
in
separating
patients
with
tangential
gunshot
wounds
to
the
abdomen
from
those
with
intra-abdominal
injury
but
may
miss
patients
with
intra-abdominal
hemorrhage

Diagnostic
peritoneal
lavage
is
highly
predictive
of
the
presence
of
intra-abdominal
injury

Also
,
its
was
determined
the
morphology
and
quantification
of
parasites

RESULTS
:
Parasites
were
identified
in
26.2
%
of
population

In
21
patients
B

hominis
(
group
C
)
was
observed
in
absence
of
other
enteropathogens

hominis
present
and
stool
characteristics

<
TO_SEE
>
BACKGROUND
:
The
cause
of
severe
acquired
hyperammonemia
,
an
uncommon
but
often
fatal
complication
of
organ
transplantation
and
chemotherapy
for
cancer
,
is
obscure

The
activity
of
hepatic
glutamine
synthetase
was
markedly
reduced
(
in
patient
1
,
12
%
of
the
mean
value
in
controls
;
in
patient
2
,
28
%
of
the
mean
value
in
controls
)
,
and
a
concomitant
reduction
in
the
amount
of
glutamine
synthetase
protein
was
observed

Postnatal
growth
was
prospectively
measured
from
birth
to
1
y
in
54
term
infants
born
small
for
gestational
age
(
SGA
)
,
fed
either
breast
milk
or
a
standard
term
infant
formula

Breastfeeding
was
associated
with
a
0.36
and
0.64
standard
deviation
(
SD
)
increase
in
weight
at
2
weeks
and
3
months
of
age
,
respectively
,
which
persisted
beyond
the
breastfeeding
period
(
0.64
SD
at
1
y
)

This
increased
growth
was
independent
of
potentially
confounding
obstetric
,
social
and
demographic
factors

However
,
it
may
be
even
more
important
that
the
nurses
themselves
have
a
healthy
lifestyle
,
thus
serving
as
role
models
for
patients

Descriptive
statistics
were
used
to
analyze
the
data
retrieved
from
the
questionnaires

RESULTS
:
More
than
70
%
of
the
critical
care
nurses
who
responded
engage
in
exercise
and
follow
a
healthy
,
low-fat
diet

Seventy-one
percent
said
that
they
anticipate
making
a
change
in
their
lifestyle
in
the
future
,
and
70
%
said
that
they
would
recommend
their
lifestyle
to
their
patients

(
2
)
Incorporating
a
healthy
lifestyle
was
easy
for
some
and
a
struggle
for
others

(
3
)
Critical
care
nurses
readily
listed
barriers
to
healthy
living

The
CYP1A1
MspI
heterozygous
genotype
was
present
in
18
percent
of
cases
and
16
percent
of
controls
,
and
one
percent
of
cases
and
controls
were
CYP1A1
MspI
homozygous
variant

The
GSTM1
null
genotype
was
detected
in
54
percent
of
cases
and
52
percent
of
controls

BACKGROUND
:
Thrombolytic
treatment
has
been
shown
to
accelerate
resolution
of
major
pulmonary
embolism
and
lead
to
a
rapid
improvement
of
right-side
hemodynamics

Symptom
onset
was
acute
(
&
#
60
;
48
hours
)
in
63
%
of
patients

Clinical
factors
associated
with
a
higher
death
rate
were
syncope
(
P=.012
)
,
arterial
hypotension
(
P=.021
)
,
history
of
congestive
heart
failure
(
P=.013
)
,
and
chronic
pulmonary
disease
(
P=.032
)

However
,
only
primary
thrombolysis
was
found
by
multivariate
analysis
to
be
an
independent
predictor
of
survival
(
odds
ratio
for
in-hospital
death
,
0.46
;
95
%
confidence
interval
,
0.21
to
1.00
)

A
66-year-old
male
engineer
diagnosed
with
malignant
pleural
mesothelioma
4
years
previously
had
thoracotomy
,
radiotherapy
,
and
chemotherapy

Review
of
the
literature
disclosed
no
previously
documented
similar
occurrence

Thirty-four
(
94
%
)
of
the
36
patients
enjoyed
sustained
moderate
or
marked
improvement
of
their
parkinsonian
symptoms
6
months
postoperatively

The
pallidal
radiofrequency
lesions
were
prolate
spheroid
shaped
and
were
composed
of
three
concentric
zones
in
the
early
postoperative
studies

Additional
edema
spreading
to
the
internal
capsule
was
noted
in
32
of
34
cases
and
to
the
optic
tract
in
11
of
34
cases

In
three
patients
no
lesion
was
identified
despite
sustained
clinical
improvement

The
lesion
was
located
in
the
posteroventral
GPi
in
all
cases
except
in
one
patient
in
whom
it
was
confined
to
the
GP
externus
(
GPe
)

This
49-year-old
woman
did
not
experience
sustained
benefit

The
authors
found
no
consistent
correlations
between
lesion
size
and
location
and
clinical
outcome
as
measured
by
a
global
outcome
score
,
the
Unified
Parkinson
's
Disease
Rating
Scale
motor
,
activities
of
daily
living
,
and
bradykinesia
``
off
''
scores
or
rating
of
dyskinesias

OBJECTIVE
:
We
determined
the
sensitivity
and
specificity
of
neonatal
brain-stem
auditory
evoked
potentials
(
BAEP
)
as
markers
for
subsequent
hearing
impairment
and
for
developmental
problems
found
later
in
infancy
and
childhood

Behavioral
audiometry
was
repeated
during
periodic
follow-up
until
reliable
responses
were
obtained
for
all
frequencies
,
and
standardized
developmental
testing
was
also
conducted

Therefore
the
sensitivity
of
neonatal
BAEP
testing
for
predicting
subsequent
hearing
loss
was
only
42
%

In
contrast
,
on
language
development
testing
,
19
children
demonstrated
receptive
language
delay

Because
neonatal
ECMO
is
associated
with
a
high
risk
of
hearing
and
receptive
language
disorders
,
parents
should
be
counseled
that
audiologic
and
developmental
follow-up
evaluations
in
surviving
children
are
essential
regardless
of
the
results
of
neonatal
BAEP
testing

It
assumes
that
a
single
pathway
is
sufficient
for
educating
general
internists
and
subspecialty-bound
trainees

BACKGROUND
:
Darier
disease
is
an
uncommon
genodermatosis
characterized
by
the
symmetrical
eruption
of
keratotic
reddish-brown
papules
occurring
in
the
seborrheic
areas
of
the
body

A
unilateral
,
or
localized
,
variant
has
been
identified

The
implications
of
these
cases
on
future
genetic
studies
are
also
discussed

The
average
age
at
onset
was
27
years

This
condition
was
aggravated
by
sunlight
,
heat
,
or
sweating
in
42
%
(
19/40
)
of
reported
cases
,
and
38
%
(
15/40
)
of
the
patients
responded
to
treatment
with
topical
tretinoin

Further
studies
of
localized
Darier
disease
may
therefore
prove
to
be
instrumental
in
the
search
for
the
Darier
disease
gene

In
addition
,
we
are
able
to
generate
plants
in
which
only
CPDs
or
6-4
products
are
photoreactivated
in
the
nuclear
genome
by
exposing
these
mutants
to
UV
light
and
then
allowing
them
to
repair
one
or
the
other
class
of
dimers

Minimal
or
no
cutaneous
signs
were
present

Moreover
,
the
girl
had
no
antibodies
against
this
toxin

The
serum
cytokine
profile
during
the
acute
phase
of
her
illness
showed
high
levels
of
tumor
necrosis
factor-alpha
,
interleukin-6
and
interferon-gamma
,
as
is
seen
during
activation
of
the
immune
system
by
TSS
toxin
1

Other
possible
causes
for
the
patient
's
illness
were
excluded

It
is
possible
that
some
cases
of
syndrome
of
hemorrhagic
shock
and
encephalopathy
represent
a
variant
of
TSS
in
small
children

After
completion
of
chemotherapy
and
normalization
of
tumor
markers
,
both
patients
presented
with
pulmonary
symptoms
attributable
to
their
massively
enlarging
mediastinal
teratomas
.

The
chicken
calmodulin
I
(
CaMI
)
gene
has
been
isolated
and
characterized
on
the
level
of
cDNA
and
genomic
DNA

The
deduced
amino
acid
(
aa
)
sequence
is
identical
to
the
one
of
chicken
CaMII
which
consists
of
148
aa

The
CaMI
gene
contains
six
exons

Its
intron/exon
organization
is
identical
to
that
of
the
chicken
CaMII
and
the
CaMI
and
CaMIII
genes
of
rat
and
human

The
gene
is
transcribed
into
four
mRNAs
of
0.8
,
1.4
,
1.7
and
4.4
kb
as
determined
by
Northern
blot
analysis

When
revascularizations
were
included
,
there
was
a
significant
trend
toward
higher
frequencies
of
events
with
increasing
calcium
quantity
(
P
&
#
60
;
.01
)

However
,
coronary
death
and
infarction
were
not
significantly
more
frequent
in
higher
quartiles

CONCLUSIONS
:
Calcium
quantities
from
the
3-mm
and
the
more
reproducible
6-mm
scanning
are
equally
accurate
for
predicting
events

Research
into
sexual
orientation-simplistically
referred
to
as
``
gay
gene
''
research-is
an
example
of
research
that
provokes
intense
controversy

Many
homosexual
people
have
been
forced
to
undergo
``
treatments
''
to
change
their
sexual
orientation

But
there
are
other
reasons
to
worry
about
such
research

The
efficiency
of
testicular
sperm
retrieval
by
testicular
fine
needle
aspiration
(
TEFNA
)
was
compared
with
open
biopsy
and
testicular
sperm
extraction
(
TESE
)
,
in
37
rigorously
selected
patients
with
non-obstructive
azoospermia

The
mean
age
of
the
male
patients
was
32.7
years
(
range
24-47
)

The
negative
predictive
value
of
high
serum
follicle
stimulating
hormone
(
FSH
)
concentrations
(
>
or
=10
IU/l
)
(
predicting
failure
to
find
spermatozoa
for
ICSI
)
was
low
(
38.4
%
)

The
positive
predictive
value
(
predicting
the
chance
to
find
spermatozoa
for
ICSI
)
of
normal-sized
testicle
was
not
different
from
that
of
small-sized
(
&
#
60
;
15
ml
)
testicle
(
50
%
)

Complications
included
one
case
of
testicular
bleeding
following
fine
needle
aspiration
,
treated
locally
,
and
two
cases
of
extratunical
haematomata
following
TESE
requiring
no
intervention

<
TO_SEE
>
In
patients
with
non-obstructive
azoospermia
,
TEFNA
has
a
significantly
lower
yield
compared
to
TESE

The
implantation
and
pregnancy
rates
per
embryo
transfer
were
13
and
29
%
respectively

Neither
serum
FSH
values
nor
testicular
size
were
predictive
of
the
chances
to
find
spermatozoa
for
ICSI

Some
complications
may
occur
even
following
TEFNA

Recently
,
the
putative
BCL-1
proto-oncogene
turned
out
to
be
none
other
than
the
cyclin
D1
gene

Although
the
observed
break
points
in
the
BCL-1
locus
are
not
tightly
clustered
,
its
rearrangement
has
been
documented
in
40-70
%
of
cases
of
mantle
cell
lymphoma
,
whereas
it
only
rarely
occurs
in
other
B
cell
lymphomas

In
PC12
cells
,
a
model
system
to
study
neurite
outgrowth
,
SHARP
genes
can
be
induced
by
NGF
with
the
kinetics
of
an
immediate-early
gene

The
embryonic
development
of
the
face
has
been
studied
in
many
reviews
,
this
work
purposes
only
to
clear
up
some
points
which
remain
obscure
concerning
cervico-facial
morphogenesis

In
the
first
part
of
this
study
only
the
facial
development
,
properly
speaking
,
is
considered
,
although
it
can
not
be
separate
of
cervical
development
to
which
a
second
study
will
be
reserved

Then
we
approach
among
other
things
the
way
to
consider
the
maxillary
process
with
regard
to
the
other
facial
processes

A
case-control
study
was
performed
in
eight
pairs
of
women
to
determine
whether
preeclamptic
women
developed
abnormalities
in
minor
hemoglobins
,
glycolytic
enzymes
,
or
other
blood
components
that
might
provide
insight
into
the
pathophysiology
of
preeclampsia
,
or
that
in
combination
might
be
used
as
a
marker
for
the
condition

These
variables
and
standard
clinical
tests
were
analyzed
as
discriminators
between
preeclamptic
and
control
women

The
subjects
were
matched
for
age
,
ethnicity
,
parity
,
and
gestational
age

Variables
differing
significantly
between
groups
included
increases
in
uric
acid
(
UA
)
,
low-density
lipoproteins
(
LDL
)
,
phosphoglycerate
kinase
(
PGK
)
,
and
mean
platelet
volume
(
MPV
)
,
and
decreases
in
glyceraldehyde
phosphate
dehydrogenase
(
G3PD
)
in
preeclamptic
women
compared
to
normal
controls

Discriminant
analysis
revealed
the
following
function
to
separate
the
groups
:
0.7764
(
UA
)
+
0.8086
(
PGK
)
-0.7032
(
G3PD
)
+
0.1399
(
LDL
)
-0.2386
(
MPV
)

The
results
are
consistent
with
perturbations
in
red
cell
glycolysis
in
preeclampsia

Mouse
monoclonal
antibodies
specific
for
thiabendazole
(
a
post-harvest
fungicide
and
veterinary
anthelmintic
)
were
covalently
linked
through
free
amine
groups
to
aminosilanized
silicon
dioxide
films
using
glutaraldehyde

Immobilized
antibody
layers
were
stabilized
with
sucrose
,
dehydrated
,
and
stored
refrigerated
with
desiccant

Exposed
regions
of
immobilized
antibody
were
then
removed
by
exposure
to
a
low
power
,
radio
frequency
oxygen
discharge

Challenge
with
enzyme
linked
antigen
of
oxygen
plasma
exposed
antibody
layers
demonstrated
that
plasma
treatment
completely
neutralized
antibody
capture
ability

Ellipsometry
measurements
of
oxygen
plasma
exposed
antibody
layers
indicated
complete
removal
of
immobilized
antibodies

Fluorescent
imaging
demonstrated
smallest
line
widths
of
2-3
microns

A
key
feature
is
that
these
immune
cells
can
be
selectively
engineered
to
recognize
specific
antigens
in
vitro

We
have
previously
determined
that
mast
cell
metabolic
responses
can
be
thermally
transduced
in
real
time
,
thus
indicating
the
possibility
of
whole
cell
thermoelectric
immunobiosensing

The
method
is
based
on
an
evanescent
wave
generated
from
a
tapered
configuration
of
decladded
optical
fibre
and
does
not
require
any
volumetric
measurement

Tapered
fibres
are
immobilized
with
the
purified
cell
surface
protein
of
L.
donovani
by
covalent
bonding

Fluorescent
intensity
from
the
fibre
has
been
shown
to
be
proportional
to
L.
donovani
specific
antibodies
present
in
the
test
sera

Direct
readings
can
be
obtained
after
signal
enhancement
through
a
photomultiplier
tube
within
5
min

The
system
,
when
tested
on
12
positive
sera
,
did
not
show
any
false
negative
result

The
four
structurally
different
intercalators
showed
significant
distinction
in
binding
kinetics
and
equilibrium
signals

The
accuracy
is
demonstrated
by
the
measurement
of
control
sera

Both
physiological
and
pathological
materials
correlate
well
with
the
declared
values

The
dry
stored
lactate
catheter
needs
about
10
min
for
hydration
and
is
characterized
by
response
times
t98
%
of
less
than
2
min

Often
,
the
binding
kinetics
may
be
described
by
a
single-fractal
analysis

It
is
of
interest
to
note
that
the
state
of
disorder
(
or
the
fractal
dimension
)
and
the
binding
rate
coefficient
both
increase
as
the
reaction
progresses
on
the
biosensor
surface

Also
,
the
magnitude
of
the
changes
in
the
binding
rate
coefficients
(
k1
and
k2
)
and
in
the
fractal
dimensions
(
Df1
and
Df2
)
as
different
parameters
are
changed
for
the
different
biosensor
applications
are
of
particular
value
,
since
they
provide
us
with
a
measure
or
extent
of
changes
in
the
binding
rate
coefficient
on
changing
different
experimental
parameter
values

It
is
of
interest
to
note
the
effect
of
different
parameters
on
the
extent
or
heterogeneity
that
exists
on
the
surface
and
how
this
influences
the
binding
rate
coefficients

If
no
microscopic
urinalysis
is
required
,
testing
turn-around
time
is
reduced
by
12.3
min/test
and
the
hospital
charge
is
reduced
from
U.S

In
all
simple
salines
,
irrespective
of
their
osmolarity
,
Lucifer
Yellow
CH
was
found
to
preferentially
migrate
in
the
posterior
direction
and
to
accumulate
in
the
oocyte
due
to
progressive
binding
to
yolk
spheres

Thus
,
with
this
sensitive
method
,
no
correlation
was
detectable
between
the
external
osmolarity
,
the
electrical
charge
and
the
preferential
direction
of
migration
of
a
microinjected
probe

The
AF-4
gene
on
human
chromosome
4q21
is
involved
in
reciprocal
translocations
to
the
ALL-1
gene
on
chromosome
11q23
,
which
are
associated
with
acute
lymphoblastic
leukaemias

A
set
of
recombinant
phage
carrying
genomic
fragments
for
the
coding
region
and
flanking
sequences
of
the
AF-4
gene
were
isolated

Phage
inserts
were
assembled
into
four
contigs
with
21
exons
,
and
an
intron
phase
map
was
produced
enabling
the
interpretation
of
translocation-generated
fusion
proteins

Polyclonal
antisera
directed
against
three
different
portions
of
the
AF-4
protein
were
produced
and
used
to
detect
a
116
kD
protein
in
cellular
extracts
of
human
B-lymphoblastoid
and
proB
cell
lines

Comparison
of
AF-4
protein
coding
sequences
with
the
LAF-4
and
FMR-2
sequences
revealed
five
highly
conserved
domains
of
potential
functional
relevance

In
the
present
study
,
we
report
the
molecular
cloning
of
three
isoforms
,
the
biochemical
analysis
and
the
immunohistochemical
characterization
of
one
of
the
proteins
identified
in
this
screen

We
identify
three
different
mRNA
forms
of
chLAMP
and
show
that
two
forms
with
distinct
5'-termini
are
differentially
transcribed
in
neural
development

Two
novel
cDNAs
,
DNAS1L2
and
DNAS1L3
,
are
predicted
to
encode
proteins
of
299
and
305
amino
acids
with
56
and
46
%
residue
identity
(
71
and
63
%
similarity
)
,
respectively
,
to
deoxyribonuclease
I
(
DNase
I
)

Northern
analysis
revealed
DNAS1L3
expression
nearly
exclusively
in
liver
,
while
DNAS1L2
expression
was
detected
in
brain
by
RT-PCR

Thus
,
to
date
,
four
DNase
I-like
genes
that
show
different
tissue
expression
patterns
are
known

In
the
second
group
,
a
rebound
in
virus
levels
in
plasma
followed
the
initial
sharp
decline
observed
at
the
start
of
therapy

This
was
associated
with
the
emergence
of
drug-resistant
variants

Sequence
analysis
of
the
protease
gene
during
the
course
of
therapy
revealed
that
in
this
second
group
there
was
a
sequential
acquisition
of
protease
mutations
at
amino
acids
46
,
82
,
54
,
71
,
89
,
and
90

Recombinant
HIV-1
variants
containing
two
or
three
mutations
in
the
protease
gene
were
constructed
either
with
mutations
at
the
p7/p1
cleavage
site
or
with
wild-type
(
WT
)
gag
sequences

Introduction
of
an
additional
mutation
at
the
gag
p7/p1
protease
cleavage
site
compensated
for
the
partially
defective
protease
gene

Optimal
rates
of
virus
replication
require
protease
cleavage
of
precursor
polyproteins

A
mutation
in
the
cleavage
site
that
enhanced
the
availability
of
a
protein
that
was
rate
limiting
for
virus
maturation
would
confer
on
that
virus
a
significant
growth
advantage
and
may
explain
the
uniform
emergence
of
viruses
with
alterations
at
the
p7/p1
cleavage
site

Activation
of
Raf-1
kinase
resulted
in
a
delayed
and
sustained
increase
of
HMGI-C
expression
in
the
Pa-4
cells

The
induction
of
HMGI-C
mRNA
level
is
sensitive
to
both
the
protein
synthesis
inhibitor
cycloheximide
and
transcription
inhibitor
actinomycin
D

The
predicted
protein
,
pendrin
,
is
closely
related
to
a
number
of
known
sulphate
transporters

The
procedure
involves
directed
microdissection
of
one
defined
subchromosomal
area
,
its
DOP-PCR-amplification
and
cloning

Linkage
analysis
assigned
six
of
them
to
their
predefined
subchromosomal
origin
on
BTA
6
corresponding
to
the
specific
rehybridization
signal
of
the
DOP-PCR
product
generated
from
the
microdissected
chromosome
area
6q21-31

Phylogeographic
structure
was
determined
for
the
yellow
mongoose
,
Cynictis
penicillata
,
using
mtDNA
RFLPs
and
control
region
sequences

The
lipophilic
character
of
dioxins
prevents
their
excretion
in
the
urine
and
causes
their
accumulation
in
body
fat

Recent
experimental
data
also
indicate
that
dioxins
can
cause
dysfunction
of
the
sexual
and
thyroid
hormone
systems
and
that
the
administration
of
dioxins
induces
several
conditions
related
to
hormonal
dysfunction

Chronic
exposure
of
female
Rhesus
monkeys
increases
the
incidence
and
severity
of
endometriosis

The
administration
of
dioxins
during
pregnancy
and
nursing
causes
altered
development
of
the
reproductive
system
,
decreased
spermatogenesis
,
hypothyroidism
and
disturbed
psychomotor
development
in
the
offspring

New
diagnostic
criteria
lowered
the
cut
off
value
to
126
mg/dl
,
in
order
to
detect
more
rapidly
diabetes
and
its
complications

These
last
drugs
seem
very
attractive
because
they
decrease
insulin
resistance
in
obese
,
diabetics

Their
hepatic
side
effects
must
be
however
under
control

Better
knowledge
of
non
lipidic
effects
of
statins
on
the
arterial
wall
and
the
discovery
of
the
action
of
fibrates
on
PPAR
(
Peroxisome
Proliferator
Activated
Receptors
)
improved
strongly
the
therapeutic
management
of
hyperlipidemias

However
,
these
results
have
to
be
confirmed
by
larger
trials
,
currently
underway
,
before
to
consider
that
beta-blockade
should
definitely
be
incorporated
in
the
treatment
of
heart
failure

Sumatriptan
and
other
selective
serotonin
agonists
represent
a
major
breakthrough
in
acute
migraine
treatment

A
single
training
bout
per
day
was
previously
considered
sufficient
,
whereas
today
athletes
regularly
train
twice
a
day
or
more

Consequently
,
the
number
of
athletes
who
are
overtraining
and
have
insufficient
rest
is
increasing

However
,
negative
overtraining
,
causing
maladaptation
and
other
negative
consequences
such
as
staleness
,
can
occur

Physiological
,
psychological
,
biochemical
and
immunological
symptoms
must
be
considered
,
both
independently
and
together
,
to
fully
understand
the
'staleness
'
syndrome

The
time
frame
of
training
and
recovery
is
also
important
since
the
consequences
of
negative
overtraining
comprise
an
overtraining-response
continuum
from
short
to
long
term
effects

For
an
elite
athlete
to
refrain
from
training
for
>
72
hours
is
extremely
undesirable
,
highlighting
the
importance
of
a
carefully
monitored
recovery
process

One
such
framework
for
this
is
referred
to
as
the
total
quality
recovery
(
TQR
)
process

By
using
a
TQR
scale
,
structured
around
the
scale
developed
for
ratings
of
perceived
exertion
(
RPE
)
,
the
recovery
process
can
be
monitored
and
matched
against
the
breakdown
(
training
)
process
(
TQR
versus
RPE
)

The
TQR
scale
emphasises
both
the
athlete
's
perception
of
recovery
and
the
importance
of
active
measures
to
improve
the
recovery
process

Little
attention
has
been
directed
toward
identifying
the
changes
which
occur
in
salivary
composition
in
response
to
exercise

A
knowledge
of
the
neural
control
of
salivary
secretion
is
especially
important
for
the
understanding
of
the
effects
of
exertion
on
salivary
secretion

Saliva
composition
might
therefore
be
used
as
an
alternative
noninvasive
indicator
of
the
response
of
the
different
body
tissues
and
systems
to
physical
exertion

In
this
respect
,
the
response
of
salivary
amylase
and
salivary
electrolytes
to
incremental
levels
of
exercise
is
of
particular
interest

Tsa
is
the
point
during
exercise
at
which
the
levels
of
salivary
alpha-amylase
and
electrolytes
(
especially
Na+
)
also
begin
to
rise
above
baseline
levels

It
has
been
determined
that
the
plasma
FFA
turnover
rate
is
sufficiently
rapid
to
account
for
most
of
the
fat
metabolised
during
low
intensity
exercise
(
25
to
40
%
VO2max
)

However
,
an
exercise
intensity
of
65
%
VO2max
results
in
a
slight
decrease
in
the
amount
of
plasma
FFA
uptake
by
muscle
tissue

Furthermore
,
it
is
widely
documented
that
endurance
activities
increase
the
energy
utilisation
from
fat
while
sparing
carbohydrate
sources

A
clinical
joint
study
on
insulin
therapy
,
a
survey
of
the
actual
inter-laboratory
differences
in
GHb
measurement
among
41
institutions
and
an
assessment
of
11
assay
methods
for
the
determination
of
GHb
were
performed
using
commercial
calibrators
and
fresh
blood
samples

The
recommendation
of
the
Japan
Diabetes
Society
to
measure
only
the
stable
GHb
component
and
to
correct
the
GHb
percentage
by
two-point
calibration
with
assigned
values
,
was
effective
but
not
sufficient

Users
in
clinical
practice
must
recognize
these
problems
,
and
,
before
supply
,
the
providers
should
check
their
method
and
keep
records
that
are
readily
traceable

A
postal
survey
was
performed
to
determine
the
current
practices
and
attitudes
of
radiologists
towards
the
imaging
of
suspected
lower
limb
deep
vein
thrombosis
(
DVT
)

One
hundred
and
twenty-seven
departments
responded
to
a
questionnaire
sent
in
March
1996

In
hospitals
where
venography
was
routinely
used
as
the
first
line
investigation
,
the
most
common
reasons
were
:
the
perceived
inferiority
of
ultrasound
(
US
)
in
demonstrating
below-knee
clot
,
its
time-consuming
nature
and
the
limited
access
to
suitable
ultrasound
machines

Observations
on
the
incidence
of
following
of
visual
and
auditory
stimuli
in
naive
mallard
ducklings
(
Anas
platyrhynchos
)

An
experimental
study
of
conflict
and
fear
:
an
analysis
of
behavior
of
young
chicks
toward
a
mealworm

The
measuring
function
of
the
first
legs
of
Araneus
diadematus
Cl

The
transport
of
prey
by
ants

Courtship
behaviour
in
the
Drosophila
obscura
group

Comparative
studies

Short-term
retention
as
a
function
of
method
of
measurement
,
recording
time
,
and
meaningfulness
of
the
material

Persisting
odours
as
a
biasing
factor
in
open-field
research
with
mice

Vividness
of
words
and
learning
to
learn
in
free-recall
learning

Genetic
study
of
the
memorization
of
words
and
pictures

Physico-chemical
studies
on
the
stability
of
penicillin
salts

IV

Some
inflammatory
disorders
of
the
large
intestine

Sarcoidosis
involving
the
veriform
appendix

A
method
to
aid
correct
diagnosis

Clinico-statistical
considerations
on
vescicular
mole

Epidemiology
of
hypertension

The
use
of
radioactive
isotopes
in
the
diagnosis
of
hypertension

The
angiogram
in
the
study
of
hypertension

Hepatocerebral
degeneration
(
portal
systemic
encephalopathy
)

The
relationship
to
fatty
acids

Auto-uro
therapy
:
status
and
future
prospects

Intra-arterial
infusion
of
the
head
and
neck

Anatomic
and
distributional
problems

Lymphatics
of
the
mouth
and
neck

Studies
on
contractile
properties
of
the
blood
serum

Blood
loss
in
artificial
interruption
of
pregnancy

Modified
bra
in
the
prevention
of
mastitis
in
nursing
mothers

Hormonal
phenomenon
after
the
excision
of
hydatiform
mole

The
family
physician
and
cervical
carcinoma
--
challenge
and
opportunity

Karen
:
the
other
side
of
the
picture

Rhesus
haemolytic
disease
;
an
approach
to
prevention

Tumours
of
the
uterus

Malignancy

Dumping
syndrome
following
pyloroplasty
.

Measured
subtotal
gastrectomy
for
duodenal
ulcer

The
lesions
in
bovine
udders
shedding
nonhemolytic
coagulase-negative
staphylococci

Repository
vitamin
B
12
preparations

Treatment
of
childhood
schizophrenia

Polycystic
ovaries
associated
with
congenital
adrenal
hyperplasia

A
radioautographic
study
with
H3-thymidine
on
adrenal
medulla
nuclei
of
rats
intermittently
exposed
to
cold

Effect
of
thoracic
cava
obstruction
on
response
of
proximal
tubule
sodium
reabsorption
to
saline
infusion

The
metabolism
of
intravenously
injected
isotopic
cholic
acid
in
Laennec
's
cirrhosis

The
role
of
the
liver
in
serum-induced
hypercoagulability

Etiology
and
incidence
of
renal
stones

Diagnosis
of
stone
disease

Medical
treatment
of
stone
disease

Is
the
task
hopeless
?

Comparison
of
the
international
and
American
systems
for
the
staging
of
breast
cancer

The
postprandial
period
of
the
gastrectomized
patient

Comparative
effects
of
two
benzodiazepine
compounds
on
isolated
human
myometrium

Histochemistry
of
hydrolytic
and
oxidative
enzymes
in
the
human
and
experimentally
induced
adenocarcinoma
of
the
endometrium

The
responsibilities
of
the
obstetrician

V

The
effect
of
dietary
protein
source
on
serum
proteins

Familial
vitamin
D
resistant
rickets
in
untreated
adult

Report
of
a
case
without
conjunctival
involvement

The
metabolism
of
cortisol
by
human
extra-hepatic
tissues

Aromatization
of
7-alpha-hydroxydehydroepiandrosterone
and
of
its
3-sulphate
by
ovarian
and
placental
tissue
cultures

Mutation
frequencies
detected
following
irradiation
of
virgin
and
inseminated
Drosophila
melanogaster
females

Twinning
in
relation
to
birth
weight
,
mortality
,
and
congenital
anomalies

Ovarian
carcinoma

The
problems
of
staging
and
grading

Oxytocin
induction
in
pregnant
rabbits
,
with
special
reference
to
the
stillbirth
rate

Significance
of
a
single
umbilical
artery

Perforated
peptic
ulcer
in
pregnancy

Poverty
as
an
isolated
factor
in
relation
to
perinatal
asphyxia

Gynaecological
pain

Fat
absorption
:
a
transport
problem

Analysis
of
Cr
,
Zn
,
Fe
and
Pb
contaminants
in
food
coal-tar
dyes
and
their
aluminium
lakes
by
atomic
absorption
spectrophotometry

Screening
tests
of
microorganisms
for
the
microbial
transformation
of
griseophenone
A
,
N-methylcoclaurine
and
sparteine

Determination
of
silicone
oil
in
disposable
plastic
syringes

A
tentative
draft
of
qualitative
test
of
fluoride
for
adoption
to
the
general
tests
of
eighth
revised
edition
of
the
Pharmacopoeia
of
Japan

A
note
on
the
assay
of
corticoid
preparations
by
tetrazolium
salt

Analysis
of
steroids

I
.
The
production
and
detection
of
anti-insulin
serum
and
anti-guinea-pig
globulin
rabbit
serum

Sodium
in
heart
failure

Potassium
in
heart
failure

Clinical
physiopathology
of
the
patency
of
the
interatrial
septum

Various
aspects
of
diuresis
in
heart
congestive
failure

Defects
of
the
interventricular
septum
not
associated
with
other
malformations

Clinical
physiopathology
of
the
patency
of
Botallo
's
ductus
arteriosus

Immediate
outcome
and
long-term
results
of
108
sphincterotomies
of
Oddi
's
sphincter
of
biliary
indication

Rhinitis
in
herds
with
piglet
influenza

The
stimulatory
effect
of
luteinizing
hormone
on
adenosine
3
'
,
5'-monophosphate
accumulation
in
corpus
luteum
slices

Electrolyte
and
acid-base
balance
in
fetal
and
maternal
blood

An
experimental
and
a
clinical
study

A
radium
accident
in
a
hospital

The
rate
of
severe
preeclampsia
is
increased
in
triplet
as
compared
to
twin
gestations

Pregnancy
in
chronic
progressive
external
ophthalmoplegia
:
a
case
report

Effect
of
magnesium
sulfate
on
the
development
of
cystic
periventricular
leukomalacia
in
preterm
infants

A
case
report
and
a
review
of
the
literature

Spontaneous
rectus
sheath
hematoma
during
pregnancy
mimicking
abruptio
placenta

Laryngeal
obstruction
caused
by
lingual
thyroglossal
duct
cyst
presenting
at
birth

Depression
after
childbirth
:
the
views
of
medical
students
and
women
compared

Commentary
:
are
nurses
effective
providers
of
labor
support
?
Should
they
be
?
Can
they
be
?

Commentary
:
discharge
packs
:
how
much
do
they
matter
?

Mucous
membrane
melanomas
of
the
upper
aerodigestive
tract

Are
the
products
of
CD44
exons
v5
and
v6
markers
for
metastasis
of
laryngeal
carcinomas
?

A
case
of
sarcoidosis
of
the
mastoid

Genomic
medicine

Internet
resources
for
medical
genetics

>
From
the
Centers
for
Disease
Control
and
Prevention

Chlamydia
screening
practices
of
primary-care
providers
--
Wake
County
,
North
Carolina
,
1996

Evidence
for
a
new
locus
on
chromosome
12

BRCA1
sequence
analysis
in
women
at
high
risk
for
susceptibility
mutations

Evidence
of
a
new
susceptibility
locus
in
Caucasian
and
Chinese
patients

Attitudes
toward
health-care
,
HIV
infection
,
and
perinatal
transmission
interventions
in
a
cohort
of
inner-city
,
pregnant
women

Homology
modeling
of
adenylosuccinate
synthetase
from
Saccharomyces
cerevisiae
reveals
a
possible
binding
region
for
single-stranded
ARS
sequences

The
comparison
of
the
responsiveness
of
human
isolated
internal
mammary
and
gastroepiploic
arteries
to
levcromakalim
:
an
alternative
approach
to
the
management
of
graft
spasm

Single-dose
pharmacokinetics
of
felbamate
in
patients
with
renal
dysfunction

Role
of
phosphatidylinositol
3-kinase
in
degranulation
induced
by
IgE-dependent
and
-independent
mechanisms
in
rat
basophilic
RBL-2H3
(
ml
)
cells

Elective
surgery
for
colorectal
cancer
in
the
aged
:
a
clinical-economical
evaluation

Leukaemia
and
non-Hodgkin
's
lymphoma
in
children
and
young
adults
:
are
prenatal
and
neonatal
factors
important
determinants
of
disease
?

Inverse
correlation
between
loss
of
heterozygosity
of
the
short
arm
of
chromosome
12
and
p15ink4B/p16ink4
gene
inactivation
in
childhood
acute
lymphoblastic
leukaemia

Elective
surgery
for
gastrointestinal
tumours
in
the
elderly

I
.
Introduction

II

The
roots

1981

Treatment
uncertainties
surround
early
diagnosis
of
breast
cancer

Epilepsy
and
attention
deficit
hyperactivity
disorder
:
is
methylphenidate
safe
and
effective
?

Osteopathic
manifesto

IV

V

Legislative
and
legal
vigilance

Torsion-angle
molecular
dynamics
as
a
new
efficient
tool
for
NMR
structure
calculation

Time-domain
quanification
of
amplitude
,
chemical
shift
,
apparent
relaxation
time
T2
,
and
phase
by
wavelet-transform
analysis

Investigation
of
uncertainties
in
relaxation
analysis
of
2D
NOE
which
arise
from
spectral
noise

Application
to
a
novel
tin
derivative
of
erythromycin
A

Thermoelectric
cooling
for
NMR
sample
temperature
control

H2NCO-E.COSY
,
a
simple
method
for
the
sterospecific
assignment
of
side-chain
amide
protons
in
proteins

Radiation
dosimetry
by
localized
magnetic
resonance
spectroscopy

Resolution
due
in
medical
software
regulation

1981

The
practical
use
of
PCR
for
rapid
detection
of
methicillin
resistance
among
staphylococcal
clinical
isolates
from
Turkish
hospitals

ROXIS
Study
Group

Screening
for
Chlamydia
trachomatis
?

VIII

Winning
the
war
on
cancer

Genetic
testing
opens
brave
new
world

Telemedicine
gets
a
chance
to
prove
itself

Recurrent
strokes
in
a
34-year-old
man

Another
use
of
androgens
:
treatment
of
anemia
of
end-stage
renal
disease

Isotopic
evidence
for
extraterrestrial
non-racemic
amino
acids
in
the
Murchison
meteorite

Classification
of
malignant
lymphomas
:
the
updated
Kiel
classification

Diagnosing
and
managing
polymyalgia
rheumatica
and
temporal
arteritis

Sensitivity
of
temporal
artery
biopsy
varies
with
biopsy
length
and
sectioning
strategy

Obstructive
sleep
apnoea

Search
for
studies
was
limited

Authorship

Authorship

Transurethral
microwave
thermotherapy

Environmental
tobacco
smoke
and
coronary
heart
disease

The
pruning
of
Doctor
McDonough
and
the
``
humanizing
''
of
statistics

Prevention
in
the
home
health
setting

Contempo
1997
:
obstetrics
and
gynecology

Mortality
and
refusal
of
ICU
admission

Extracorporeal
photopheresis
in
SÃ
(
c
)
zary
syndrome

Attacks
on
tobacco
industry

Does
blinding
of
readers
affect
results
of
meta-analyses
?

Consumption
of
alcohol
and
mortality
in
Russia

Conference
proceedings

Who
understands
the
menopause
?

The
US
attack
on
Cuba
's
health

Brain
serotonin
neurotoxicity
and
primary
pulmonary
hypertension
from
fenfluramine
and
dexfenfluramine

Putting
patients
first
?

Amiodarone
and
thyroid
function

<
TO_SEE
>
Probucol
and
multivitamins
in
the
prevention
of
restenosis
after
coronary
angioplasty

Hormone
replacement
therapy

Addressing
needle-stick
concerns

Thalidomide
in
oral
Crohn
's
disease
refractory
to
conventional
medical
treatment

Treatment
of
hypertension
in
elderly
patients

Dominant
negative
and
cooperative
effects
of
mutant
forms
of
prolactin
receptor

Female
embryonic
lethality
in
mice
nullizygous
for
both
Msh2
and
p53

The
Continuous
Infusion
versus
Double-Bolus
Administration
of
Alteplase
(
COBALT
)
Investigators

Atrial
fibrillation
begets
trouble

``
Whiplash
''
injury
of
the
cervical
spine
:
value
of
modern
diagnostic
imaging

Guidelines
and
cardiac
anaesthetists

''
Combined
pediatric
and
radiation
oncology
grand
rounds
addresses
severe
illness
and
death

The
importance
of
being
where
?
Balancing
the
perspective
on
practice
coverage

Cholesterol-lowering
therapy

Progressive
sensorineural
hearing
loss
,
subjective
tinnitus
and
vertigo
caused
by
elevated
blood
lipids

Chronic
telogen
effluvium
:
potential
complication
for
clinical
trials
in
female
androgenetic
alopecia
?

Cancer
therapy
and
tumor
physiology

Mutual
relationships
based
on
equality

Hormonal
responses
to
restraint
in
rhesus
monkeys

The
role
of
procedures
in
family
practice
:
is
there
a
right
answer
?

Arthrodesis
of
the
first
metatarsophalangeal
joint
to
salvage
failed
silicone
implant
arthroplasty

Stroke
incidence
rates
among
black
residents
of
Harare
--
a
prospective
community-based
study

Unethical
trials
of
interventions
to
reduce
perinatal
transmission
of
the
human
immunodeficiency
virus
in
developing
countries

DOTS
--
are
we
over-optimistic
?

Activation
at
the
germinal
vesicle
stage
of
starfish
oocytes
produces
parthenogenetic
development
through
the
failure
of
polar
body
extrusion

Early
death
amongst
anaesthetists

Water
fluoridation
,
tooth
decay
in
5
year
olds
,
and
social
deprivation
measured
by
the
Jarman
score
:
analysis
of
data
from
British
dental
surveys

Pharmaceutical
industry
is
invited
to
respond
to
amnesty
for
unreported
trials

Should
we
screen
for
gestational
diabetes
?

Leprosy
beyond
the
year
2000

Glasgow
has
already
produced
strategy
for
treatment

Evidence
on
effectiveness
is
stronger
for
statins
than
for
other
treatments

Evidence
based
advertising
?
Half
of
drug
advertisements
in
BMJ
over
six
months
cited
no
supporting
evidence

Non-steroidal
anti-inflammatory
therapy
for
bronchial
asthma

Drugs
for
the
Third
World

Pure
alexia
could
not
be
a
disconnection
syndrome

A
randomized
,
double-blind
,
dose-response
comparison
of
epidural
fentanyl
versus
sufentanil
analgesia
after
cesarean
section

Spontaneous
splenic
rupture
following
administration
of
granulocyte
colony-stimulating
factor
(
G-CSF
)
:
occurrence
in
an
allogeneic
donor
of
peripheral
blood
stem
cells

The
American
Urological
Association

Weekly
clinicopathological
exercises

A
preterm
newborn
female
triplet
with
diffuse
cystic
changes
in
the
left
lung

Back
from
the
dead
:
extracorporeal
rewarming
of
severe
accidental
hypothermia
victims
in
accident
and
emergency

EU
directive
on
bovine
spongiform
encephalopathy
will
not
affect
drugs

Management
of
patients
with
HIV/AIDS

Pregnancy
outcomes
in
women
with
gestational
diabetes
compared
with
the
general
obstetric
population

Lumbar
puncture
need
n't
be
a
headache

Randomised
controlled
trial
of
magnetic-resonance
pelvimetry
in
breech
presentation
at
term

Interview
by
Tom
Heinemann

Reducing
risk
is
best
strategy

Anesthesiology

Trouble
in
paradise

Evaluation
of
diagnostic
peritoneal
lavage
in
stable
patients
with
gunshot
wounds
to
the
abdomen

A
randomised
comparison
of
the
EuroQol
and
Short
Form-36
after
stroke

Clinical
significance
of
Blastocystis
hominis
infection
:
epidemiologic
study

Chronic
leg
ulcers
:
beware
the
'wolf
in
sheep
's
clothing
!
'
.

What
investigations
and
procedures
do
patients
in
hospices
want
?
Interview
based
survey
of
patients
and
their
nurses

Double-blind
study
of
pulsing
magnetic
field
effects
on
multiple
sclerosis
.

CDA
opposes
proposed
HBV
recommendations

Clinical
problem-solving

The
Third
International
Study
of
Infarct
Survival
Collaborative
Group

Removal
of
a
broken
solid-core
intramedullary
femoral
nail
using
both
antegrade
and
retrograde
starting
points

Does
hyperglycemia
really
cause
coronary
heart
disease
?

Diagnosis
and
therapy
of
primary
stomach
lymphoma

Consensus
of
the
Surgical
Working
Group
for
Oncology
,
the
Working
Group
for
Medical
Oncology
and
the
Working
Group
for
Radiologic
Oncology

Ovine
Johne
's
disease

Bullous
eruption
in
a
patient
with
systemic
lupus
erythematosus
:
mite
dermatitis
caused
by
Cheyletiella
blakei

A
case-control
study
of
cytochrome
P450
1A1
,
glutathione
S-transferase
M1
,
cigarette
smoking
and
lung
cancer
susceptibility
(
Massachusetts
,
United
States
)

Association
between
thrombolytic
treatment
and
the
prognosis
of
hemodynamically
stable
patients
with
major
pulmonary
embolism
:
results
of
a
multicenter
registry
.

Metastatic
malignant
mesothelioma
presenting
as
colonic
polyps

Microelectrode-guided
posteroventral
pallidotomy
for
treatment
of
Parkinson
's
disease
:
postoperative
magnetic
resonance
imaging
analysis

A
positive
cannabinoids
workplace
drug
test
following
the
ingestion
of
commercially
available
hemp
seed
oil

Goldilocks
and
Mrs

Frequent
users
of
emergency
services

Follow
up
after
potential
curative
surgery
of
colorectal
cancer

Fulminant
hepatic
failure
in
murine
hepatitis
virus
strain
3
infection
:
tissue-specific
expression
of
a
novel
fgl2
prothrombinase

The
use
and
effects
of
postcoital
contraception

Antisense
suppression
of
4-coumarate
:
coenzyme
A
ligase
activity
in
Arabidopsis
leads
to
altered
lignin
subunit
composition

<
TO_SEE
>
Alopecia
as
a
consequence
of
tacrolimus
therapy
in
renal
transplantation
?

Factors
influencing
blood
flow
in
the
optic
nerve
head

SYT-SSX
gene
fusion
as
a
determinant
of
morphology
and
prognosis
in
synovial
sarcoma

Genetic
testing
for
cancer
risk
:
how
to
reconcile
the
conflicts

A
piece
of
my
mind

Leaders
or
lemmings
?

Embryonic
stem
cells
and
hematopoietic
stem
cell
biology

Shark
cartilage
for
cancer
?

Photorepair
mutants
of
Arabidopsis

Fibromyalgia
:
La
Maladie
est
Morte

Small
cell
lung
cancer
can
express
CD34
antigen

Evaluation
of
a
ventilation
strategy
to
prevent
barotrauma
in
patients
at
high
risk
for
acute
respiratory
distress
syndrome

Audit
commission
tackles
anaesthetic
services

Translocations
of
11q13
in
mantle
cell
lymphoma
fail
to
disrupt
the
S
mu
bp-2
gene

Factors
affecting
uptake
of
antenatal
HIV
testing
in
London
:
results
of
a
multicentre
study

Peptide
nucleic
acid
(
PNA
)
from
DNA
recognition
to
antisense
and
DNA
structure

Homeopathy
for
postoperative
ileus
?
A
meta-analysis

Connexin-26
mutations
in
sporadic
non-syndromal
sensorineural
deafness

Treatment
of
hypertensive
patients
with
diabetes

China
's
human-organ
trade
highlighted
by
US
arrest
of
``
salesman
''

Administration
of
dexamethasone
induces
proteinuria
of
glomerular
origin
in
mice

Hypertension
treatment
and
control
in
sub-Saharan
Africa
:
the
epidemiological
basis
for
policy

Dual-fractal
analysis
for
antigen
--
antibody
binding
kinetics
for
biosensor
applications

Further
evidence
for
the
importance
of
an
androgen
response
element
in
the
factor
IX
promoter

High-affinity
binding
of
the
neonatal
Fc
receptor
to
its
IgG
ligand
requires
receptor
immobilization

Troponin-T
concentrations
should
be
measured

Second
Strang
International
Cancer
Conference
:
genetics
and
the
environment
New
York
,
USA
,
15-16
November
1996

Update
on
Helicobacter
pylori
research

Histologic
diagnosis
of
chronic
hepatitis
,
grading
and
staging

The
Integrative
Neurobiology
of
Affiliation

March
14-17
,
1996

August
17-22
,
1996

Neuropeptides
in
Development
and
Aging

Psychobiology
of
Postraumatic
Stress
Disorder

Proceedings
of
the
3rd
International
Congress

Oncogenic
raf-1
induces
the
expression
of
non-histone
chromosomal
architectural
protein
HMGI-C
via
a
p44/p42
mitogen-activated
protein
kinase-dependent
pathway
in
salivary
epithelial
cells

Pendred
syndrome
is
caused
by
mutations
in
a
putative
sulphate
transporter
gene
(
PDS
)

Proceedings
of
the
VIIIth
International
Conference
on
the
Na/K-ATPase
and
Related
Transport
ATPases

Proceedings

Joint
meeting
of
the
Benelux
Society
for
Microcirculation
and
the
Gesellschaft
fÃ1/4r
Mikrozirkulation
e.V

Mainz
,
Germany
,
October
23-25
,
1997

International
forensic
science
and
justice

Paris
,
France
,
March
6-7
,
1997

Proposed
genetic
nomenclature
rules
for
Tetrahymena
thermophila
,
Paramecium
primaurelia
and
Paramecium
tetraurelia

The
Seventh
International
Meeting
on
Ciliate
Molecular
Biology
Genetics
Nomenclature

Neurone
development
and
death
,
from
a
cell
biologist
's
perspective

3rd
Neurotrauma/Polytrauma
Symposium

Bethesda
,
Maryland
,
USA

November
13-15
,
1996

Copenhagen
,
23-26
October
1997

Abstracts

Bethesda
,
Maryland
,
USA

December
5
,
1997

Infectious
diseases
:
their
impact
on
dentistry

What
's
new
in
protein
folding
?
EMBO
workshop
:
protein
folding
and
misfolding
inside
and
outside
the
cell

Meeting
of
the
European
forum
of
nurses

Serologic
evidence
for
mother-to-child
transmission
of
Kaposi
sarcoma-associated
herpesvirus
infection

New
developments
in
the
treatment
of
diabetes
and
hyperlipidemias

Role
of
beta-blockers
in
the
treatment
of
cardiac
insufficiency

Which
calcium
antagonists
for
hypertension
?

Golf
injuries

Academic
medicine
and
complementary
medicine
--
campaign
for
the
truth
in
medical
theories

Subcutaneous
hematomas
,
reduced
Quick
value

Morphology
and
molecular
biology
of
malignant
soft
tissue
sarcomas

Radiotherapy
of
soft
tissue
sarcomas

Intramedullary
metastases
of
bronchogenic
carcinoma

Nervous
system
borreliosis
with
pseudo-lymphoma
cells
in
cerebrospinal
fluid

Cranial
nerve
injuries
during
multifocal
neuropathies
with
persistent
conduction
blocks

Facial
palsy
relevant
to
HIV
seropositivity

Auditory
perception
disorders
due
to
bilateral
cortical
lesions

Generation
of
diversity
in
mammalian
gut-associated
lymphoid
tissues
:
restricted
V
gene
usage
does
not
preclude
complex
V
gene
organization

Algae
or
protozoa
:
phylogenetic
position
of
euglenophytes
and
dinoflagellates
as
inferred
from
mitochondrial
sequences

Satellite
DNA
repeat
sequence
variation
is
low
in
three
species
of
burying
beetles
in
the
genus
Nicrophorus
(
Coleoptera
:
Silphidae
)

The
importance
of
patient
registration
and
processing

Human
bodily
health
and
the
common
good

A
gross
and
microscopic
study
of
cerebral
injuries
accompanying
maxillofacial
high-velocity
projectile
wounding
in
dogs

Absorbable
suture
technique
:
solution
to
the
growth
problem
in
pediatric
pacing
with
endocardial
leads

Interview
by
Grethe
Kjaergaard

American
Diabetes
Association

Will
the
real
plastic
surgeon
please
stand
up
?

Modulation
of
ultraviolet
light-induced
epidermal
damage
:
beneficial
effects
of
tocopherol

Bilateral
sampling
of
the
internal
jugular
vein
to
distinguish
between
mechanisms
of
adrenocorticotropic
hormone-dependent
Cushing
syndrome

The
influence
of
patients
'
hopes
of
receiving
a
prescription
on
doctors
'
perceptions
and
the
decision
to
prescribe
:
a
questionnaire
survey

Coronary
endothelial
dysfunction
in
humans
is
associated
with
myocardial
perfusion
defects

American
College
of
Physicians

Management
of
vaginal
vault
prolapse

Tissue
adhesives
--
revisited

Racial
discrimination
in
the
allocation
of
distinction
awards
?
Analysis
of
list
of
award
holders
by
type
of
award
,
specialty
and
region

Providing
primary
care
in
the
accident
and
emergency
department

Chicago
report
profiles

WHO
decides
:
food
irradiation
safe
at
any
level

Genetic
sampling
:
big
brother
or
big
science
?

Physician
assistants
and
nurse
practitioners
in
hospital
outpatient
departments
,
1993-1994

The
veracious
etiology
of
ectopic
pregnancy

Is
dietary
fat
a
major
determinant
of
body
fat
?

Early
inpatient
rehabilitation
after
elective
hip
and
knee
arthroplasty

Slater
revisited
:
6
year
follow
up
study
of
patients
with
medically
unexplained
motor
symptoms

Reduced
ratio
of
male
to
female
births
in
several
industrial
countries
:
a
sentinel
health
indicator
?

Should
we
accept
mediocrity
?

Colonoscopic
removal
of
chicken
bones
impacted
in
the
sigmoid
in
two
patients

Nonneoplastic
disorders
of
the
eccrine
glands

Cerebrospinal
fluid
and
plasma
insulin
levels
in
Alzheimer
's
disease
:
relationship
to
severity
of
dementia
and
apolipoprotein
E
genotype

Remifentanil
in
the
critically
ill

Anaesthesia
for
laparoscopic
cholecystectomy
in
a
patient
with
Eisenmenger
's
syndrome

Abstracts

Vitamin
K2
and
serum
cholesterol
in
patients
on
continuous
ambulatory
peritoneal
dialysis

Clinical
evaluation
of
adjuvant
chemoradiotherapy
with
CDDP
,
5-FU
,
and
VP-16
for
advanced
esophageal
cancer

The
effect
of
a
social
support
boosting
intervention
on
stress
,
coping
,
and
social
support
in
caregivers
of
children
with
HIV/AIDS

Point-counterpoint

Persons
successful
at
long-term
weight
loss
and
maintenance
continue
to
consume
a
low-energy
,
low-fat
diet

Ultrasound
measurements
of
the
newborn
hip

Online
medical
surveys
:
using
the
Internet
as
a
research
tool

Mike
Grace
talks
to
Mike
Joy

Multivalent
cations
depress
ligand
affinity
of
insulin-like
growth
factor-binding
proteins-3
and
-5
on
human
GM-10
fibroblast
cell
surfaces

Sudden
death
in
young
athletes
:
screening
for
the
needle
in
a
haystack

<
TO_SEE
>
Prevention
of
a
first
stroke
by
transfusions
in
children
with
sickle
cell
anemia
and
abnormal
results
on
transcranial
Doppler
ultrasonography

How
to
decide
on
the
applicability
of
clinical
trial
results
to
your
patient

Causing
death
or
allowing
to
die
?
Developments
in
the
law

A
specialist
nurse
can
replace
pre-registration
house
officers
in
the
surgical
pre-admission
clinic

Ionized
magnesium
in
serum
and
ultrafiltrate
:
pH
and
bicarbonate
effect
on
measurements
with
the
AVL
988-4
electrolyte
analyzer

The
Gram
stain

When
can
odds
ratios
mislead
?

Enzyme
structure
with
two
catalytic
sites
for
double-sieve
selection
of
substrate

Role
of
the
ketogenic
diet
in
children
with
intractable
seizures
.

Evaluation
of
the
microparticle
enzyme
immunoassay
Abbott
IMx
Select
Chlamydia
and
the
importance
of
urethral
site
sampling
to
detect
Chlamydia
trachomatis
in
women

Secondary
prevention
for
stroke
after
CAPRIE
and
ESPS-2

<
TO_SEE
>
New-onset
angina
preceding
acute
myocardial
infarction
is
associated
with
improved
contractile
recovery
after
thrombolysis

Gorlin
syndrome
:
identification
of
4
novel
germ-line
mutations
of
the
human
patched
(
PTCH
)
gene

Mutations
in
brief
no

Online

Genetic
findings
in
congenital
bilateral
aplasia
of
vas
deferens
patients
and
identification
of
six
novel
mutatations

Mutations
in
brief
no

A
novel
point
mutation
in
a
splice
acceptor
site
of
intron
1
of
the
human
low
density
lipoprotein
receptor
gene
which
causes
severe
hypercholesterolemia
:
an
unexpected
absence
of
exon
skipping

Mutations
in
brief
no

A
de
novo
missense
mutation
(
R1623Q
)
of
the
SCN5A
gene
in
a
Japanese
girl
with
sporadic
long
QT
sydrome

Mutations
in
brief
no

A
new
informative
Alw
26
I
polymorphism
in
exon
10
of
the
human
low
density
lipoprotein
receptor
gene

145

146

Online

Significance
of
revision
of
the
occupational
illness
legislation
for
evaluating
intervertebral
disk
damage

Microalbuminuria
is
positively
associated
with
usual
dietary
saturated
fat
intake
and
negatively
associated
with
usual
dietary
protein
intake
in
people
with
insulin-dependent
diabetes
mellitus

The
Stresst'er
ergometer
as
an
alternative
to
treadmill
testing
in
patients
with
claudication

Placebo
in
drug
clinical
trials

A
simple
technique
for
correction
of
mucosal
irregularities
of
the
lip

Helicobacter
pylori
and
abdominal
symptoms
:
a
population-based
study
among
preschool
children
in
southern
Germany

Have
we
treated
AIDS
too
well
?
Rationing
and
the
future
of
AIDS
exceptionalism

Recommendations
on
antiretroviral
treatment

Safe
motherhood
:
can
we
make
a
difference
?

Lumbar
spine
stenosis
:
a
common
cause
of
back
and
leg
pain

Myoepithelial
carcinoma
with
predominance
of
plasmacytoid
cells
arising
in
a
pleomorphic
adenoma
of
the
parotid
gland

Doing
everything

Online

Identification
of
a
large
insertion
and
two
novel
point
mutations
(
3671del8
and
S1221X
)
in
tuberous
sclerosis
complex
(
TSC
)
patients

Online

Mutational
analysis
of
the
cystathionine
beta-synthase
gene
:
a
splicing
mutation
,
two
missense
mutations
and
an
insertion
in
patients
with
homocystinuria

Analysis
of
five
mutations
in
20
mucopolysaccharidois
type
1
patients
:
high
prevalence
of
the
W402X
mutation

121

Online

Mutations
in
brief
no

122

Use
of
public
performance
reports
:
a
survey
of
patients
undergoing
cardiac
surgery

Re
:
Friday
afternoon
pulmonary
arteriography
(
FAPA
)
:
are
Fridays
good
for
your
health
?

Hormone
replacement
therapy
and
breast
cancer
.

Polymorphism
in
promoter
region
of
inducible
nitric
oxide
synthase
gene
and
protection
against
malaria

A
systematic
review
of
five
systemic
treatments
for
severe
psoriasis

Trisomy
10
in
leukemia

Risk
factors
for
hemiretinal
vein
occlusion
:
comparison
with
risk
factors
for
central
and
branch
retinal
vein
occlusion
:
the
eye
disease
case-control
study

Relatives
in
the
resuscitation
room
:
their
point
of
view

Acute
obstructive
hydrocephalus
complicating
bacterial
meningitis
in
childhood

Subcutaneous
autologous
ovarian
transplantation
in
Wistar
rats
maintains
hormone
secretion

How
do
you
treat
refractory
pouchitis
and
when
do
you
decide
to
remove
the
pouch
?

Clinical
comparison
with
iomeprol
and
ioxaglate

A
new
modified
technique
for
harvest
of
calcaneal
bone
grafts
in
surgery
on
the
foot
and
ankle

Epilepsy
--
a
guide
to
medical
treatment

Adolescent
pregnancy
and
sexual
abuse

Still
hard
to
know
how
large
the
benefits
will
really
be

conclusions
:
apc
is
effective
for
the
treatment
of
endoluminal
hemoptysis
and
airway
obstruction

conclusion
:
as
expected
,
the
type
of
chemotherapy
we
used
,
to
treat
non-seminomatous
germ-cell
tumors
proved
to
be
highly
effective
for
seminomatous
types
,
as
well

these
results
suggested
that
the
sp1
decoy
strategy
would
be
effective
for
regulating
tumor
growth
by
simultaneously
reducing
cancer
cell
(
a
)
angiogenic
growth
factor
expression
,
(
b
)
proliferation
,
and
(
c
)
invasiveness

considering
that
hamsters
had
a
lung
metastasis
rate
of
50
%
before
mdp-lys
treatment
,
liposomal
mdp-lys
given
at
a
dose
of
20
microg
twice/week
was
effective
for
inhibiting
lung
metastasis
at
a
far
lower
dose
of
mdp-lys
than
that
given
as
a
solution
(
40
microg
vs.
350
microg
per
week
)

we
have
documented
previously
that
adenovirus-mediated
interleukin
12
(
il-12
)
gene
therapy
is
effective
for
orthotopic
tumor
control
and
suppression
of
pre-established
metastases
in
a
preclinical
prostate
cancer
model
(
y.
nasu
et
al
.
,
gene
ther

clinically
,
oral
administration
of
uft
has
proved
to
be
effective
as
an
adjuvant
therapy
after
surgery
for
some
malignant
tumors
such
as
non-small
cell
lung
cancer

moreover
,
uft
has
proved
to
be
effective
for
inoperable
advanced
malignancies
such
as
colorectal
cancer
,
especially
in
combination
with
leucovorin
or
cisplatin

in
conclusion
,
fractionated
administration
of
cpt-11
and
cddp
was
highly
effective
for
advanced
nsclc
with
manageable
toxicities

weekly
paclitaxel
was
very
well
tolerated
,
yet
was
effective
for
recurrent
cervical
adenocarcinoma

reviewer
's
conclusions
:
a
single
dose
of
nasal
decongestant
in
the
common
cold
is
moderately
effective
for
the
short
term
relief
of
congestion
in
adults
,
while
there
is
no
evidence
available
to
show
benefit
after
repeated
use
over
several
days

conclusions
:
members
of
an
ethnically
diverse
community
believe
antibiotics
are
effective
for
colds
,
are
very
likely
to
seek
care
for
colds
,
and
often
obtain
antibiotics
without
a
prescription

<
TO_SEE
>
the
availability
of
four
antiviral
agents
that
effectively
prevent
and
treat
influenza
provides
the
physician
with
considerable
flexibility
for
their
use
in
influenza
control

background
and
objectives
:
thoracic
paravertebral
block
(
tpvb
)
is
a
unilateral
analgesic
technique
that
has
been
advocated
in
both
acute
and
chronic
thoracic
and
abdominal
pain

this
report
illustrates
that
tpvb
could
also
be
effective
for
this
kind
of
pain

conclusions
:
this
case
report
supports
the
notion
that
,
in
practice
,
the
paravertebral
block
could
be
an
effective
and
safe
alternative
to
relief
of
pleuritic
pain

one
course
of
chronochemotherapy
was
effective
for
lymph
node
and
peritoneum
metastases

the
only
specific
antidote
for
dosage-dependent
hepatotoxicity
is
n-acetylcysteine
(
and
some
other
sulfhydryl
donors
)
,
which
is
highly
effective
for
the
prevention
of
significant
hepatotoxicity
after
acetaminophen
overdose

two
triazole
antifungal
agents
,
fluconazole
and
itraconazole
,
were
introduced
over
a
decade
ago
and
since
then
have
been
used
extensively
for
the
prophylaxis
and
treatment
of
a
variety
of
fungal
infections

the
use
of
topical
corticosteroids
has
revolutionised
the
treatment
of
inflammatory
skin
diseases

in
particular
,
tacrolimus
and
ascomycin
derivatives
have
been
shown
to
be
effective
for
treating
atopic
dermatitism
with
a
surprising
lack
of
side
effects

the
cancer
and
leukemia
group
b
performed
a
series
of
studies
involving
sequential
chemotherapy
followed
by
radiation
for
patients
with
unresectable
stage
iii
nsclc

only
22
patients
(
10
%
)
were
alive
at
five
years
:
19
patients
with
nsclc
who
had
got
surgical
treatment
,
one
patient
with
nsclc
(
stage
iiib
)
who
had
recieved
radiotherapy
,
and
two
patients
with
sclc
,
limited
disease
,
treated
with
chemo-
and
radiotherapy

whether
the
era
of
platinum-based
chemotherapy
in
the
treatment
of
nsclc
should
continue
or
not
must
be
determined
by
phase
iii
trials
,
evaluating
the
use
of
a
platinum
agent
with
one
of
the
new
agent
combinations

in
three
patients
with
bos
and
concurrent
acute
rejection
,
therapy
with
extracorporeal
photopheresis
led
to
the
resolution
of
the
acute
rejection
episode

conclusion
:
extracorporeal
photopheresis
appears
to
be
a
promising
therapy
for
patients
with
early
bos

purpose
:
many
patients
with
locally
advanced
non-small-cell
lung
cancer
(
la-nsclc
)
are
eligible
for
combined-modality
therapy
(
cmt
;
chemotherapy
and
radiotherapy
)

objective
:
to
report
the
use
of
heparin
and
enoxaparin
for
radiation-induced
myelopathy

conclusion
:
vip
combination
chemotherapy
and
early
concurrent
thoracic
irradiation
for
patients
with
limited
stage
small
cell
lung
cancer
revealed
excellent
antitumor
response
with
tolerable
toxicity

<
TO_SEE
>
mediastinoscopy
facilitates
identification
of
patients
with
regionally
advanced
disease
prior
to
resection
,
allowing
neoadjuvant
therapy
and
avoiding
unnecessary
resections

we
evaluated
the
role
of
systemic
chemotherapy
for
patients
with
malignant
pleural
effusions
from
nsclc

in
contrast
,
the
introduction
and
improvement
of
chemotherapy
since
the
1970s
gave
rise
to
an
improvement
in
-
only
short-term
(
<
2
years
)
-
survival
for
patients
with
small-cell
lung
cancer

the
degree
of
healing
and
damage
of
the
bronchial
wall
after
photodynamic
therapy
,
nd-yag
laser
and
electrocautery
for
intraluminal
early-stage
cancer
have
been
analysed

to
examine
whether
efficacy
of
postoperative
oral
administration
of
uft
,
a
5-fluorouracil
derivative
chemotherapeutic
agent
,
may
be
influenced
by
incidence
of
apoptosis
(
apoptosis
index
)
or
apoptosis-related
gene
status
(
p53
and
bcl-2
)
of
the
tumour
,
a
total
of
162
patients
with
pathologic
stage
i
non-small
cell
lung
cancer
were
retrospectively
reviewed

is
prolonged
survival
possible
for
patients
with
supraclavicular
node
metastases
in
nsclc
treated
with
chemoradiotherapy
?
ijrobp
1999
;
44
(
4
)
:
847-853

we
aimed
to
investigate
whether
biological
factors
related
to
radiosensitivity
and
chemosensitivity
have
prognostic
significance
in
non-small-cell-lung-cancer
(
nsclc
)
patients
treated
with
daily
low
doses
of
cisplatin
and
radiotherapy

methods
:
we
placed
stents
for
both
esophageal
and
tracheobronchial
stenoses
in
8
patients
(
7
with
esophageal
cancer
and
1
with
lung
cancer
)

conclusions
:
for
patients
with
both
esophageal
and
tracheobronchial
stenoses
,
a
stent
should
be
introduced
into
the
tracheobronchus
first

a
retrospective
immunohistochemical
study
was
performed
on
material
from
patients
who
were
newly
diagnosed
with
osteogenic
sarcoma
who
were
treated
according
to
the
t12
protocol
from
the
authors
'
institution
between
1986
to
1993

for
patients
with
lung
carcinoma
who
are
in
relatively
poor
health
,
the
authors
chose
videothoracoscopic
lobectomy
or
partial
resection
of
the
lung
instead
of
an
open
thoracotomy

background
:
curative
therapy
is
available
for
patients
with
stage
0
lung
carcinoma
,
with
a
>
90
%
5-year
survival
rate

in
the
gks
group
,
large
lesions
(
>
30
mm
)
were
removed
surgically
and
all
other
small
lesions
(
<
or
=
30
mm
)
were
treated
by
gks

patients
with
a
single
non-sclc
,
breast
,
melanoma
,
renal
cell
,
and
ovarian
carcinoma
brain
metastasis
have
the
best
chance
for
long-term
survival
if
treated
with
surgical
resection
and
wbrt

methods
:
over
90
months
,
therapeutic
vats
metastasectomy
was
accomplished
upon
80
patients
with
colorectal
metastases

patients
with
limited-stage
small-cell
carcinoma
of
the
lung
are
treated
with
combined-modality
therapy
with
the
intent
to
cure

methods
:
we
analyzed
30
patients
who
were
discovered
to
have
brain
metastases
during
the
diagnosis
of
121
patients
enrolled
in
three
consecutive
clinical
trials
on
advanced
nsclc
assessing
combination
chemotherapy
of
cisplatin
,
ifosfamide
and
irinotecan
with
rhg-csf
support

in
patients
with
metastatic
colorectal
cancer
,
intravenous
oxaliplatin
has
been
trialled
as
a
monotherapy
and
in
combination
with
other
agents

in
addition
,
oxaliplatin
has
shown
efficacy
in
patients
with
platinum-pretreated
ovarian
cancer
and
achieved
objective
response
rates
similar
to
paclitaxel
in
this
setting
(
16
vs
17
%
)

promising
results
have
also
been
found
with
oxaliplatin
in
patients
with
non-hodgkin
's
lymphoma
,
breast
cancer
,
mesothelioma
and
non-small
cell
lung
cancer

additional
clinical
investigation
of
oxaliplatin
in
patients
with
other
cancers
is
warranted
given
the
promising
results
achieved
in
early
trials
,
most
notably
in
patients
with
platinum-pretreated
ovarian
cancer

the
current
study
was
designed
to
assess
the
prognostic
value
of
immunomorphologic
changes
in
locoregional
lymph
nodes
and
lymphocytic
infiltration
of
primary
tumor
(
li
)
in
patients
who
undergo
resection
for
bronchogenic
carcinoma

the
drug
is
currently
in
phase
iii
clinical
trials
for
patients
with
non-small
cell
lung
cancer
in
combination
with
paclitaxel
and
carboplatin
,
as
well
as
in
advanced
hormone
refractory
prostate
cancer
in
combination
with
mitoxantrone

of
1
,
042
patients
with
primary
lung
cancer
who
underwent
resection
from
1982
to
1995
,
549
patients
with
adenocarcinoma
(
ad
)
and
363
with
squamous
cell
carcinoma
(
sq
)
were
included
in
this
study

chemotherapy
administered
before
surgery
or
definitive
irradiation
has
improved
survival
rates
in
patients
with
stage
iii
nsclc

objectives
:
this
study
aims
to
test
whether
prophylactic
cranial
irradiation
prolongs
survival
of
patients
with
small
cell
lung
cancer
in
complete
remission

combination
chemotherapy
is
the
cornerstone
of
treatment
that
confers
a
meaningful
survival
benefit
for
patients
with
small-cell
lung
cancer

for
symptomatic
metastases
in
bone
or
brain
,
radiotherapy
usually
gives
temporary
palliation

for
intrathoracic
relapse
and
severe
obstruction
of
main
bronchus
and/or
superior
caval
vein
,
radiotherapy
is
a
possibility
if
not
given
as
part
of
first-line
treatment

tumor
vaccines
against
gangliosides
that
are
expressed
on
almost
all
human
sclc
cells
have
been
recently
developed

sample
:
45
adults
with
primary
cancer
of
the
lung
receiving
<
outpatient
primary
or
adjuvant
radiation
therapy

conclusions
:
this
study
is
the
first
to
evaluate
planned
sequential
chemotherapy
in
patients
with
nsclc

purpose
:
this
randomized
trial
was
designed
to
determine
whether
paclitaxel
plus
carboplatin
(
pc
)
offered
a
survival
advantage
over
vinorelbine
plus
cisplatin
(
vc
)
for
patients
with
advanced
non
--
small-cell
lung
cancer

conclusion
:
pc
is
equally
efficacious
as
vc
for
the
treatment
of
advanced
non
--
small-cell
lung
cancer

conclusions
:
the
intensification
of
platinum
dose
(
cisplatin
plus
carboplatin
)
in
combination
chemotherapy
significantly
increased
the
complete
response
rate
,
overall
survival
and
number
of
two-year
survivors
among
sclc
patients
with
limited
disease
compared
to
combination
therapy
with
carboplatin
alone
,
suggesting
that
a
more
aggressive
treatment
to
this
category
of
patients
is
worthwhile
,
while
no
difference
in
treatment
outcome
was
observed
for
patients
with
extensive
disease

the
aim
of
this
study
was
to
investigate
the
relationships
among
technetium-99m
tetrofosmin
(
tc-tf
)
accumulation
in
untreated
small
cell
lung
cancer
(
sclc
)
,
the
expression
of
p-glycoprotein
(
pgp
)
and
multidrug
resistance
related
protein-1
(
mrp1
)
,
and
the
response
to
chemotherapy
in
patients
with
untreated
sclc

in
the
present
report
,
we
reviewed
articles
on
pulmonary
angiography
for
patients
with
pulmonary
hypertension

animal
studies
suggest
that
the
kidney
is
involved
in
the
elimination
of
recombinant
human
granulocyte
colony-stimulating
factor
(
rhg-csf
)
,
which
is
used
for
patients
with
neutropenia
during
cancer
chemotherapy

amifostine
(
wr-2721
)
is
a
cytoprotective
agent
that
protects
a
broad
range
of
normal
tissues
from
the
toxic
effects
of
chemotherapy
and
radiotherapy
without
attenuating
tumour
response

<
TO_SEE
>
in
another
randomised
phase
iii
trial
in
303
patients
with
head
and
neck
cancer
undergoing
irradiation
therapy
(
total
dose
50
to
70gy
)
,
pretreatment
with
intravenous
amifostine
200
mg/m2
significantly
reduced
the
incidence
of
acute
and
late
grade
>
or
=2
xerostomia

A
review
of
the
fetal-maternal
carboxyhemoglobin
relationships
and
the
differences
in
fetal
oxyhemoglobin
physiology
are
used
to
explain
the
recommendation
that
pregnant
women
with
carbon
monoxide
poisoning
should
receive
100
%
oxygen
therapy
for
up
to
five
times
longer
than
is
otherwise
necessary

Therapeutic
effect
of
a
left
ventricular
assist
device
on
acute
myocardial
infarction
evaluated
by
magnetic
resonance
imaging

Successful
treatment
of
psoriasis
with
topical
application
of
active
vitamin
D3
analogue
,
1
alpha
,
24-dihydroxycholecalciferol

We
suggest
that
1
alpha
,
24
(
OH
)
2D3
merits
further
investigation
as
a
potentially
useful
topical
therapy
for
psoriasis

Supramaximal
horizontal
rectus
surgery
in
the
management
of
third
and
sixth
nerve
palsy

Supramaximal
medial
and
lateral
rectus
surgery
was
performed
to
correct
horizontal
deviations
in
seven
cases
of
sixth
nerve
palsy
and
three
cases
of
third
nerve
palsy
,
with
satisfactory
results
in
most
cases

Ninety-six
patients
with
disseminated
malignant
melanoma
received
thrice
weekly
intramuscular
injections
of
leukocyte
A
recombinant
interferon
(
rIFN-alpha
A
,
Roferon-A
,
Hoffmann
La
Roche
)
at
doses
of
12
X
10
(
6
)
U/m2
or
50
X
10
(
6
)
U/m2
with
or
without
cimetidine
as
an
immunorestorative
agent

Ten
patients
with
advanced
stage
(
TNM
IIB-IVB
)
mycosis
fungoides
were
treated
with
a
combination
chemotherapy
program
consisting
of
bleomycin
and
methotrexate
weekly
,
doxorubicin
every
3
weeks
,
and
topical
nitrogen
mustard
daily
(
BAM-M
)

Guiding
surgical
therapy
of
ventricular
tachycardia
by
preoperative
endocardial
catheter
mapping
necessitates
improvement
of
the
accuracy
of
localization
of
the
arrhythmogenic
site

Since
few
trials
have
examined
the
effects
of
therapeutic
supplementation
and
their
results
have
been
variable
,
further
therapeutic
trials
are
required
to
examine
the
role
of
vitamin
C
in
the
treatment
of
colds

The
PR
was
observed
in
one
patient
with
non-functioning
endocrine
pancreatic
tumor
with
progressive
liver
and
lymph
node
metastases
after
16
months
of
i.m
.
lanreotide
therapy

Inchinko-to
(
TJ-135
)
is
a
herbal
medicine
consisting
of
three
kinds
of
crude
drugs
,
and
in
Japan
it
is
administered
mainly
to
patients
with
cholestasis

Therefore
administration
of
TJ-135
may
be
useful
in
patients
with
severe
acute
hepatitis
accompanying
cholestasis
or
in
those
with
autoimmune
hepatitis

Surgical
management
of
syringomyelia
associated
with
spinal
adhesive
arachnoiditis

Traditionally
,
the
therapy
of
symptomatic
bronchiectasis
is
based
on
antibiotics
,
antibronchoobstructive
medication
,
and
chest
physical
therapy

Prospective
,
randomized
,
largescale
trials
supporting
any
of
the
different
treatment
strategies
are
not
available
,
but
antibiotics
and
surgery
probably
have
improved
the
long-term
outcome
of
many
patients
with
bronchiectasis

Patients
with
classical
symptoms
such
as
heartburn
and
regurgitation
may
be
treated
pharmaceutically
combined
with
life
style
counselling

The
surgical
treatment
of
lung
lacerations
and
major
bronchial
disruptions
caused
by
blunt
thoracic
trauma

BACKGROUND
:
An
increasing
number
of
reports
indicate
symptomatic
relief
of
biliary
colic
symptoms
after
cholecystectomy
for
biliary
dyskinesia

Cholecystectomy
should
be
a
first-line
therapy
for
biliary
dyskinesia
patients

Effectiveness
of
pseudoephedrine
plus
acetaminophen
for
treatment
of
symptoms
attributed
to
the
paranasal
sinuses
associated
with
the
common
cold

METHODS
AND
RESULTS
:
From
1959
to
1998
,
84
patients
underwent
a
total
of
90
operations
for
treatment
of
pulmonary
aspergilloma
in
the
Marie-Lannelongue
Hospital

The
lesion
was
resected
by
video-assisted
thoracoscopic
surgery
because
it
was
suspected
of
being
a
lung
abscess
that
had
caused
repeated
episodes
of
inflammation

Interferon
plays
a
critical
role
in
the
host
's
natural
defense
against
viral
infections
and
in
their
treatment

CONCLUSION
:
The
WDTA
is
an
intrinsically
motivating
educational
program
that
has
the
ability
to
effect
determinants
of
asthma
self-management
behavior
in
9-
to
13-year-old
children
with
asthma

Second
,
children
in
the
first
year
of
life
are
at
highest
risk
of
progression
and
should
be
treated
with
trimethoprim-sulfamethoxazole
to
prevent
Pneumocystis
carinii
pneumonia
,
and
targeted
for
receiving
antiretrovirals

Effectiveness
of
casein
hydrolysate
feedings
in
infants
with
colic
(
see
comments
)

We
conclude
that
antimicrobial/
antituberculous
agents
have
only
a
minor
short-term
effect
in
long-lasting
CGM
of
undetermined
cause

The
patient
had
previously
been
immunized
with
two
doses
of
Hib
conjugate
vaccine
(
PRP-T
)

AIM
:
To
assess
the
impact
on
community-based
pediatricians
of
the
conclusions
of
the
10th
Conference
de
Consensus
en
Therapeutique
Anti-Infectieuse
(
CCTAI
)
on
the
antibiotic
treatment
in
acute
nasopharyngitis
(
ANP
)

We
assessed
the
prevalence
of
head
louse
infestation
and
the
effectiveness
of
1
%
permethrin
against
head
lice
in
Kosovar
refugees

We
conclude
that
1
%
permethrin
treatment
was
effective
in
louse
control
in
this
refugee
population

PURPOSE
:
Macrolide
antibiotics
are
frequently
prescribed
to
patients
with
symptoms
of
a
common
cold

Because
the
symptoms
of
rhinovirus
colds
are
attributed
to
the
inflammatory
response
to
infection
,
we
studied
the
effects
of
treatment
with
clarithromycin
on
the
symptomatic
and
inflammatory
response
to
nasal
inoculation
with
rhinovirus

Therapeutic
pneumothorax
(
TP
)
proved
its
efficacy
in
pre-antibiotic
era
,
so
one
can
assume
that
it
can
be
applied
with
the
same
success
in
multidrug
resistant
TB

The
ruptured
horn
was
excised
by
laparotomy

Clinical
trials
show
levofloxacin
to
be
as
effective
as
cephalosporins
in
acute
exacerbation
of
chronic
bronchitis
and
as
effective
as
co-amoxiclav
,
cephalosporins
or
amoxycillin
in
community-acquired
pneumonia

Additionally
,
epidemiologic
evidence
of
a
marked
decline
in
new
KS
since
the
widespread
use
of
highly
active
antiretroviral
therapy
(
HAART
)
advocates
its
use

Humoral
immune
response
after
vaccination
against
influenza
in
patients
with
breast
cancer

Gingyo-san
and
its
components
were
administered
orally
to
mice
1
day
before
,
then
1
and
4
days
after
the
inhalation
of
a
mouse-adopted
strain
of
influenza
A2
(
H2N2
)
virus

Patients
with
evidence
of
infection
with
H.
pylori
were
treated
with
a
combination
of
omeprazole
,
amoxicillin
,
and
clarithromycin

BACKGROUND
:
Drainage
methods
for
the
gastric
conduit
after
esophagectomy
for
carcinoma
have
been
controversial

Contemporary
asthma
management
guidelines
list
inhaled
corticosteroids
as
the
preferred
controller
medication
for
patients
with
persistent
asthma

Fluticasone
propionate
is
one
of
several
inhaled
corticosteroids
used
for
the
treatment
of
asthma

Combination
therapy
with
interferon-alpha
(
IFN
alpha
)
plus
Ribavirin
has
been
shown
to
improve
the
response
rate
in
patients
with
chronic
hepatitis
C
as
compared
to
IFN
alpha
alone

To
prove
,
whether
Ribavirin
has
any
additional
effect
on
the
decline
of
hepatitis
C
viremia
during
the
first
weeks
of
treatment
patients
with
and
without
combination
therapy
were
compared

Use
of
ES
to
treat
CBD
stones
on
a
routine
basis
was
therefore
not
found
to
be
any
better
than
one-time
surgical
exploration

Effect
of
cholecystectomy
on
gastroesophageal
and
duodenogastric
reflux

He
needed
mechanical
ventilation
for
severe
hypoxemia
,
but
recovered
with
glucocorticoid
pulse
therapy

CONCLUSION
:
In
patients
with
asthma
receiving
repeated
inhaled
doses
of
FP
,
the
systemic
exposure
(
AUC
)
after
inhalation
from
the
Diskus
was
similar
to
that
from
the
Diskhaler
,
with
no
difference
between
the
DPIs
in
the
effects
on
cortisol
suppression

CONCLUSIONS
:
Amoxicillin
remains
the
antibiotic
of
choice
for
initial
empiric
treatment
of
AOM
,
although
the
traditional
dosage
should
be
increased
in
patients
at
risk
for
drug-resistant
S.
pneumoniae

This
model
can
be
used
to
test
the
safety
and
efficacy
of
liver-assist
devices
aimed
at
temporizing
the
detoxification
functions
of
the
failing
liver

Recent
major
epidemiologic
trends
in
bacterial
meningitis
include
a
dramatic
decline
in
the
incidence
of
Haemophilus
influenzae
meningitis
since
the
introduction
of
the
protein-conjugated
H.
influenzae
vaccines
,
and
a
worldwide
increase
in
infections
with
antibiotic-resistant
strains
of
bacterial
pathogens

Sida
cordifolia
L.
(
Malvaceae
)
is
used
in
folk
medicine
for
the
treatment
of
inflammation
of
the
oral
mucosa
,
blenorrhea
,
asthmatic
bronchitis
and
nasal
congestion

New
vaccines
are
under
study
to
further
control
bacterial
meningitis

The
study
involved
117
infants
(
mean
age
2.6
months
)
,
who
needed
hospital
treatment
because
of
RSV
bronchiolitis

OBJECTIVE
:
This
study
was
designed
to
evaluate
the
safety
and
estimate
the
efficacy
of
oral
budesonide
in
patients
with
primary
sclerosing
cholangitis
(
PSC
)

The
purpose
of
this
study
was
to
determine
if
topical
DL-alpha-tocopherol
(
vitamin
E
)
could
reduce
ultraviolet-induced
damage
to
the
epidermis

OBJECTIVE
:
This
study
aimed
to
determine
the
effect
of
external
beam
radiation
therapy
on
choroidal
neovascularization
(
CNV
)
secondary
to
age-related
macular
degeneration
(
AMD
)

Thrombolytic
therapy
has
been
accepted
in
the
treatment
of
acute
myocardial
infarction

<
TO_SEE
>
CASE
SUMMARY
:
A
92-year
old
white
woman
who
was
receiving
venlafaxine
for
management
of
depression
was
found
to
have
hyponatremia

Touch
sensibility
was
assessed
with
von
Frey
's
monofilaments
in
the
breasts
of
10
healthy
women
(
controls
)
and
of
80
women
with
breast
cancer
who
at
least
1
year
previously
had
undergone
subcutaneous
mastectomy
and
immediate
reconstruction
with
a
prosthesis

<
TO_SEE
>
CONCLUSIONS
:
Malnourished
patients
with
chronic
renal
failure
receiving
PN
are
at
risk
of
developing
electrolyte
abnormalities
,
particularly
hypophosphatemia

Aortocoronary
bypass
grafting
is
an
accepted
procedure
for
ischemic
heart
disease

Immunotherapy
of
mice
with
preexisting
cancers
with
heat
shock
protein
preparations
derived
from
autologous
cancer
resulted
in
retarded
progression
of
the
primary
cancer
,
a
reduced
metastatic
load
,
and
prolongation
of
life-span

Subcutaneous
injection
of
irradiated
LLC-IL2
did
not
affect
the
growth
of
preexisting
s.c.
tumors
and
also
did
not
improve
survival
of
mice
bearing
the
lung
or
peritoneal
tumors

We
describe
such
an
event
in
a
man
who
underwent
allogeneic
BMT
for
APL
in
second
relapse
and
4
years
later
presented
with
testicular
relapse

<
TO_SEE
>
CONCLUSION
:
Direct
PTA
may
be
performed
safely
as
an
alternative
to
thrombolytic
therapy
in
patients
with
acute
occlusion
of
the
middle
cerebral
artery
when
early
CT
findings
and/or
lenticulostriate
artery
involvement
are
present
or
when
superselective
local
angiography
shows
the
presence
of
a
large
embolus
or
high-grade
stenosis

Therefore
,
prudent
management
and
use
of
washed
red
blood
cells
transfusion
would
prevent
hemolytic
aggravation
even
in
open
heart
surgery

We
report
the
first
case
(
to
our
knowledge
)
of
an
endoscopic
removal
of
a
forehead
soft
tissue
mass

As
the
overview
shows
,
both
groups
of
substances
are
useful
for
individualized
treatment
of
benign
prostatic
hyperplasia
(
BPH
)
,
provided
that
conservative
pharmacological
treatment
of
BPH
is
basically
accepted
and
that
the
patients
'
quality
of
life
is
also
considered

Besides
the
well-known
nonsteroidal
antiinflammatory
drugs
(
NSAID
)
for
the
treatment
of
rheumatic
pain
herbal
medicine
can
also
be
applied
successfully

High-dose
intravenous
immunoglobulin
(
hdIVIg
)
is
increasingly
used
to
treat
a
range
of
inflammatory
and
autoimmune
diseases

We
describe
a
technique
that
enables
the
autologous
repair
of
large
midline
incisional
hernias
by
restoring
the
functional
musculoaponeurotic
support
of
the
abdominal
wall

METHODS
:
During
a
19-month
period
,
seven
children
with
empyema
underwent
thoracoscopy

While
these
findings
are
observed
for
all
classes
of
oral
drugs
,
the
issue
is
especially
critical
for
cancer
chemotherapy
,
in
which
a
narrow
therapeutic
index
is
frequently
observed

Therefore
,
interest
is
growing
in
mAbs
as
therapeutic
alternatives
for
patients
with
low-grade
NHL
and
those
with
transformed
histology

The
activity
of
oral
UFT
in
large-bowel
cancer
when
administered
with
oral
LV
(
approximately
50
mg/dose
)
has
resulted
in
objective
response
rates
of
approximately
40
%

CONCLUSION
:
UFT
is
a
fluoropyrimidine
active
in
colorectal
cancer

BACKGROUND
:
Adrenalectomy
is
the
current
treatment
for
phaeochromocytoma

As
single
agent
therapy
in
malignant
melanoma
,
interferon
alfa-2a
was
only
marginally
useful
in
most
patients

Studies
with
various
interferon
alpha
preparations
,
including
interferons
induced
in
human
leukocytes
,
interferon
alfa-N1
,
interferon
alfa-2a
,
and
interferon
alfa-2b
,
have
all
provided
evidence
for
modest
but
reproducible
antitumor
activity
in
advanced
renal
cell
carcinoma

The
rationale
for
antileukemic
therapy
in
hairy
cell
leukemia
is
to
reduce
the
significant
risk
of
infection
and
other
potential
serious
complications

Recombinant
and
natural
forms
of
interferon
alpha
have
been
shown
to
bring
about
tumor
regressions
in
patients
with
low-grade
non-Hodgkin
's
lymphoma

Current
studies
using
interferon
in
patients
with
low-grade
non-Hodgkin
's
lymphomas
are
evaluating
lower
,
and
perhaps
better
tolerated
doses
of
interferon

While
the
demonstrated
antiviral
,
antiproliferative
,
and
immunomodulatory
properties
of
interferons
have
led
to
a
number
of
theories
regarding
their
potential
use
in
treating
individuals
with
chronic
myelogenous
leukemia
(
CML
)
,
their
limited
availability
has
prevented
thorough
clinical
investigation

Intrathecal
sufentanil
provides
approximately
2
h
of
excellent
labor
analgesia
with
minimal
motor
blockade

OBJECTIVE
:
We
report
the
results
of
a
double-blind
,
double-dummy
,
active-control
study
designed
to
evaluate
the
efficacy
and
safety
of
lamotrigine
(
LTG
)
administered
as
monotherapy
to
adult
outpatients
with
partial
seizures

We
conducted
a
long-term
trial
of
docosahexanoic
acid
(
DHA
)
-concentrated
fish
oil
capsules
for
patients
in
a
high-risk
group
for
colorectal
cancer

This
article
reviews
current
trends
in
management
of
esophageal
achalasia
,
highlighting
short-term
outcome
and
cost
comparisons
of
three
treatments
:
botulinum
toxin
injection
,
pneumatic
dilation
,
and
laparoscopic
myotomy

The
clinical
application
of
therapeutic
hysteroscopy
,
mainly
in
the
field
of
the
treatment
of
abnormal
uterine
bleeding
,
started
in
the
1980s

Treatment
of
irritable
bowel
syndrome
with
Chinese
herbal
medicine
:
a
randomized
controlled
trial

Tubularized
incised
plate
hypospadias
repair
for
proximal
hypospadias

Comparison
of
radical
prostatectomy
and
iodine
125
interstitial
radiotherapy
for
the
treatment
of
clinically
localized
prostate
cancer
:
a
7-year
biochemical
(
PSA
)
progression
analysis

Immunotherapy
of
tumors
with
autologous
tumor-derived
heat
shock
protein
preparations

European
register
of
patients
with
sickle
cell
disease
treated
with
hydroxyurea
is
being
set
up

Haematoma
block
versus
intravenous
regional
anaesthesia
in
Colles
'
fractures

Protective
effect
of
pralidoxime
on
muscle
fiber
necrosis
induced
by
organophosphate
compounds

Statins
for
prevention
of
stroke

Effect
of
photodynamic
therapy
in
combination
with
mitomycin
C
on
a
mitomycin-resistant
bladder
cancer
cell
line

In
vitro
and
in
vivo
comparison
between
the
effects
of
treatment
with
adenosine
triphosphate
and
treatment
with
buthionine
sulfoximine
on
chemosensitization
and
tumour
growth
of
B16
melanoma

Effects
of
transpupillary
thermotherapy
on
immunological
parameters
and
apoptosis
in
a
case
of
primary
uveal
melanoma

Nerve-sparing
surgery
for
advanced
rectal
cancer
patients
:
special
reference
to
Dukes
C
patients

Current
surgical
therapy
for
bronchiectasis

Thoracoscopic
surgery
for
spontaneous
pneumothorax

Transabdominal
extensive
esophagogastric
devascularization
with
gastroesophageal
stapling
for
management
of
noncirrhotic
portal
hypertension
:
long-term
results

Sliding
door
technique
for
the
repair
of
midline
incisional
hernias

Thoracoscopy
for
empyema
in
children

Conventional
treatments
for
non-Hodgkin
's
lymphoma
:
the
need
for
new
therapies

Antiplatelet
therapy
in
acute
cerebral
ischemia

Excimer
laser
assisted
in
situ
keratomileusis
for
hyperopia

Interferon
treatment
of
renal
cell
carcinoma

Antimicrobial
treatment
options
in
the
management
of
odontogenic
infections

An
active-control
trial
of
lamotrigine
monotherapy
for
partial
seizures

Gene
therapy
for
myocardial
angiogenesis

Acid
suppression
therapy
in
Barrett
's
esophagus
:
the
importance
of
pH
monitoring

Physiologic
treatment
of
depressive
reactions
:
a
pilot
study

Treatment
of
hydrocele
and
cysts
of
the
epididymis
with
sclerosing
injections
of
quinine
and
urea
chlorhydrolactate
in
a
30
per
cent
solution

The
treatment
of
autoimmune
hemolytic
anemia
with
heparin

Effects
of
clomiphene
citrate
on
endometrial
hyperplasia
in
the
premenopausal
female

Prolonged
use
of
methyldopa
in
severe
hypertension
in
pregnancy

Glutathione
S-transferase
activity
in
epithelial
ovarian
cancer
:
association
with
response
to
chemotherapy
and
disease
outcome

<
TO_SEE
>
Frontal
dysfunction
blocks
the
therapeutic
effect
of
THA
on
attention
in
Alzheimer
's
disease

Corticosteroid
injections
for
sciatica

<
TO_SEE
>
Antiplatelet
therapy
to
prevent
stroke
:
risk
of
brain
hemorrhage
and
efficacy
in
atrial
fibrillation

Another
potential
use
of
troglitazone
in
noninsulin-dependent
diabetes
mellitus

Are
ABVD
and
MOPP/ABV
truly
equivalent
for
treating
Hodgkin
's
disease
at
advanced
stages
?

Paclitaxel
for
the
treatment
of
lymphoma

Percutaneous
transluminal
angioplasty
in
the
treatment
of
renovascular
hypertension
:
sequential
prospective
study

A
comparison
of
rectal
diazepam
gel
and
placebo
for
acute
repetitive
seizures

5-year
outcome
of
surgical
resection
and
watchful
waiting
for
men
with
moderately
symptomatic
benign
prostatic
hyperplasia
:
a
Department
of
Veterans
Affairs
cooperative
study

Single
or
double
lung
transplantation
for
pulmonary
hypertension

Interferon
beta
treatment
for
multiple
sclerosis

Intravenous
immunoglobulin
treatment
in
multiple
sclerosis

Perceived
contraindications
to
thrombolytic
treatment
in
acute
myocardial
infarction

Antibiotics
after
dog
bite

Stereotactic
radiosurgery
for
acoustic
neuroma
:
a
Canadian
perspective

Hematopoietic
stem-cell
transplantation
for
the
treatment
of
severe
combined
immunodeficiency

Hyperbaric
oxygen
therapy
for
children
with
cerebral
palsy

Peripheral
retinal
cryotherapy
for
postvitrectomy
diabetic
vitreous
hemorrhage
in
phakic
patients

Hyperbaric
or
normobaric
oxygen
for
acute
carbon
monoxide
poisoning
:
a
randomised
controlled
clinical
trial

Matrix
metalloproteinase
inhibitors
in
the
treatment
of
cancer

A
randomized
,
controlled
study
in
adults
of
the
immunogenicity
of
a
novel
hepatitis
B
vaccine
containing
MF59
adjuvant

Protection
of
swine
from
foot-and-mouth
disease
with
one
dose
of
an
all-D
retro
peptide

Field
evaluation
of
the
clinical
effectiveness
of
vaccines
against
pertussis
,
measles
,
rubella
and
mumps
:
comments

Transmural
drainage
of
pancreatic
fluid
collections
without
electrocautery
using
the
Seldinger
technique

Alterations
of
monocyte
function
in
patients
with
growth
hormone
(
GH
)
deficiency
:
effect
of
substitutive
GH
therapy

<
TO_SEE
>
Safety
trial
with
the
5HT1B/1D
agonist
avitriptan
(
BMS-180048
)
in
patients
with
migraine
who
have
experienced
pressure
,
tightness
,
and/or
pain
in
the
chest
,
neck
,
and/or
throat
following
sumatriptan

The
outcome
of
arthroscopic
treatment
of
temporomandibular
joint
arthropathy

Neostigmine
for
acute
colonic
pseudo-obstruction

<
TO_SEE
>
The
effect
of
bisoprolol
on
perioperative
mortality
and
myocardial
infarction
in
high-risk
patients
undergoing
vascular
surgery

Surgical
management
of
severe
secondary
peritonitis

Treatment
of
hypertension
with
ascorbic
acid

Efficacy
of
open-bite
treatment
with
the
Thera-spoon

Hepatic
arterial
infusion
of
chemotherapy
after
resection
of
hepatic
metastases
from
colorectal
cancer

Evidence
for
double
resistance
to
permethrin
and
malathion
in
head
lice

Urgent
colonoscopy
for
the
diagnosis
and
treatment
of
severe
diverticular
hemorrhage

Effects
of
tolcapone
,
a
catechol-O-methyltransferase
inhibitor
,
on
motor
symptoms
and
pharmacokinetics
of
levodopa
in
patients
with
Parkinson
's
disease
.

Dry
powdered
formoterol
,
twice
a
day
versus
aerosolized
salbutamol
,
four
times
a
day
,
in
patients
with
stable
asthma

Celecoxib
for
arthritis

Poliomyelitis
prevention
:
revised
recommendations
for
use
of
inactivated
and
live
oral
poliovirus
vaccines

Brimonidine
tartrate
0.2
%
twice
daily
vs
timolol
0.5
%
twice
daily
:
1-year
results
in
glaucoma
patients

Epoetin
:
a
pharmacoeconomic
review
of
its
use
in
chronic
renal
failure
and
its
effects
on
quality
of
life

Reduction
of
vasoreactivity
and
thrombogenicity
with
laser-thermal
angioplasty
:
comparison
with
balloon
angioplasty

Effects
of
ultrasound
energy
on
total
peripheral
artery
occlusions
:
initial
angiographic
and
angioscopic
results
.

High-dose
chemotherapy
with
autologous
stem-cell
support
for
epithelial
ovarian
cancer

``
Tandem
''
high-dose
chemoradiotherapy
with
autologous
stem-cell
support
in
the
treatment
of
newly
diagnosed
or
responsive
multiple
myeloma

Intravenous
immune
globulin
for
recurrent
spontaneous
abortion