diff --git a/CHANGELOG.md b/CHANGELOG.md
index 52be58929204..ad6bd0e82f44 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -45,6 +45,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Reset padding for `<dialog>` elements in preflight ([#11069](https://github.com/tailwindlabs/tailwindcss/pull/11069))
 - Deprecate `--no-autoprefixer` flag in the CLI ([#11280](https://github.com/tailwindlabs/tailwindcss/pull/11280))
 - Make the Rust based parser the default ([#11394](https://github.com/tailwindlabs/tailwindcss/pull/11394))
+- Simplify the `sans` font-family stack ([#11748](https://github.com/tailwindlabs/tailwindcss/pull/11748))
 
 ## [3.3.2] - 2023-04-25
 
diff --git a/src/css/preflight.css b/src/css/preflight.css
index 4935b607b540..451f0054750c 100644
--- a/src/css/preflight.css
+++ b/src/css/preflight.css
@@ -31,7 +31,7 @@ html {
   -webkit-text-size-adjust: 100%; /* 2 */
   -moz-tab-size: 4; /* 3 */
   tab-size: 4; /* 3 */
-  font-family: theme('fontFamily.sans', ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, "Noto Sans", sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"); /* 4 */
+  font-family: theme('fontFamily.sans', ui-sans-serif, system-ui, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"); /* 4 */
   font-feature-settings: theme('fontFamily.sans[1].fontFeatureSettings', normal); /* 5 */
   font-variation-settings: theme('fontFamily.sans[1].fontVariationSettings', normal); /* 6 */
 }
diff --git a/stubs/config.full.js b/stubs/config.full.js
index bda7d03ba566..bdc73f705056 100644
--- a/stubs/config.full.js
+++ b/stubs/config.full.js
@@ -303,13 +303,6 @@ module.exports = {
       sans: [
         'ui-sans-serif',
         'system-ui',
-        '-apple-system',
-        'BlinkMacSystemFont',
-        '"Segoe UI"',
-        'Roboto',
-        '"Helvetica Neue"',
-        'Arial',
-        '"Noto Sans"',
         'sans-serif',
         '"Apple Color Emoji"',
         '"Segoe UI Emoji"',
diff --git a/tests/kitchen-sink.test.js b/tests/kitchen-sink.test.js
index 73ca80fd209d..c91365732577 100644
--- a/tests/kitchen-sink.test.js
+++ b/tests/kitchen-sink.test.js
@@ -239,8 +239,7 @@ test('it works', () => {
     expect(result.css).toMatchFormattedCss(css`
       .theme-test {
         color: #3b82f6;
-        font-family: ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, Segoe UI, Roboto,
-          Helvetica Neue, Arial, Noto Sans, sans-serif, Apple Color Emoji, Segoe UI Emoji,
+        font-family: ui-sans-serif, system-ui, sans-serif, Apple Color Emoji, Segoe UI Emoji,
           Segoe UI Symbol, Noto Color Emoji;
       }
       @media (min-width: 1024px) {
diff --git a/tests/plugins/__snapshots__/preflight.test.js.snap b/tests/plugins/__snapshots__/preflight.test.js.snap
index 1cc99bb496f0..453839a4656e 100644
--- a/tests/plugins/__snapshots__/preflight.test.js.snap
+++ b/tests/plugins/__snapshots__/preflight.test.js.snap
@@ -16,7 +16,7 @@ html {
   tab-size: 4;
   font-feature-settings: normal;
   font-variation-settings: normal;
-  font-family: ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, Segoe UI, Roboto, Helvetica Neue, Arial, Noto Sans, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;
+  font-family: ui-sans-serif, system-ui, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;
   line-height: 1.5;
 }
 
@@ -209,7 +209,7 @@ html {
   tab-size: 4;
   font-feature-settings: normal;
   font-variation-settings: normal;
-  font-family: ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, Segoe UI, Roboto, Helvetica Neue, Arial, Noto Sans, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;
+  font-family: ui-sans-serif, system-ui, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;
   line-height: 1.5;
 }
 
diff --git a/tests/plugins/fontFamily.test.js b/tests/plugins/fontFamily.test.js
index ad43dc2e5d50..51091815eaca 100644
--- a/tests/plugins/fontFamily.test.js
+++ b/tests/plugins/fontFamily.test.js
@@ -6,8 +6,7 @@ quickPluginTest('fontFamily').toMatchFormattedCss(css`
       monospace;
   }
   .font-sans {
-    font-family: ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, Segoe UI, Roboto,
-      Helvetica Neue, Arial, Noto Sans, sans-serif, Apple Color Emoji, Segoe UI Emoji,
+    font-family: ui-sans-serif, system-ui, sans-serif, Apple Color Emoji, Segoe UI Emoji,
       Segoe UI Symbol, Noto Color Emoji;
   }
   .font-serif {
diff --git a/tests/raw-content.test.css b/tests/raw-content.test.css
index cc43ad4c4084..3038e8a34338 100644
--- a/tests/raw-content.test.css
+++ b/tests/raw-content.test.css
@@ -526,9 +526,8 @@
   vertical-align: middle;
 }
 .font-sans {
-  font-family: ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, Segoe UI, Roboto,
-    Helvetica Neue, Arial, Noto Sans, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol,
-    Noto Color Emoji;
+  font-family: ui-sans-serif, system-ui, sans-serif, Apple Color Emoji, Segoe UI Emoji,
+    Segoe UI Symbol, Noto Color Emoji;
 }
 .text-2xl {
   font-size: 1.5rem;
diff --git a/tests/resolveConfig.test.js b/tests/resolveConfig.test.js
index 954c406597d8..e086986326e5 100644
--- a/tests/resolveConfig.test.js
+++ b/tests/resolveConfig.test.js
@@ -148,7 +148,7 @@ test('theme key is merged instead of replaced', () => {
         'grey-lighter': '#f1f5f8',
       },
       fonts: {
-        sans: ['system-ui', 'BlinkMacSystemFont', '-apple-system', 'Roboto', 'sans-serif'],
+        sans: ['system-ui', 'Roboto', 'sans-serif'],
         serif: ['Constantia', 'Lucida Bright', 'Georgia', 'serif'],
       },
       screens: {
@@ -174,7 +174,7 @@ test('theme key is merged instead of replaced', () => {
         'grey-lighter': '#f1f5f8',
       },
       fonts: {
-        sans: ['system-ui', 'BlinkMacSystemFont', '-apple-system', 'Roboto', 'sans-serif'],
+        sans: ['system-ui', 'Roboto', 'sans-serif'],
         serif: ['Constantia', 'Lucida Bright', 'Georgia', 'serif'],
       },
       screens: {
diff --git a/tests/source-maps.test.js b/tests/source-maps.test.js
index bf7870db66fd..1233f2a46666 100644
--- a/tests/source-maps.test.js
+++ b/tests/source-maps.test.js
@@ -98,7 +98,7 @@ test('preflight + base have source maps', async () => {
       "13:2-13 -> 13:2-13",
       "14:2-31 -> 14:2-31",
       "15:2-33 -> 15:2-33",
-      "16:2-208 -> 16:2-208",
+      "16:2-121 -> 16:2-121",
       "17:2-18 -> 17:2-18",
       "18:0 -> 18:0",
       "20:0 -> 20:0",