diff --git a/package.json b/package.json
index 43b57b8381..60346d1d53 100644
--- a/package.json
+++ b/package.json
@@ -48,7 +48,7 @@
     "cron-parser": "^4.2.1",
     "get-port": "^5.1.1",
     "glob": "^7.2.0",
-    "ioredis": "^4.28.2",
+    "ioredis": "^4.28.5",
     "lodash": "^4.17.21",
     "msgpackr": "^1.4.6",
     "semver": "^6.3.0",
diff --git a/src/classes/redis-connection.ts b/src/classes/redis-connection.ts
index 4a9e3958ae..68e4804d46 100644
--- a/src/classes/redis-connection.ts
+++ b/src/classes/redis-connection.ts
@@ -58,17 +58,25 @@ export class RedisConnection extends EventEmitter {
       if (this.blocking) {
         this.opts.maxRetriesPerRequest = null;
       }
+
+      this.checkUpstashHost(this.opts.host);
     } else {
       this._client = opts;
-      this.opts = isRedisCluster(this._client)
-        ? this._client.options.redisOptions
-        : this._client.options;
+
+      if (isRedisCluster(this._client)) {
+        const hosts = (<any>this._client).startupNodes.map(
+          (node: { host: string }) => node.host,
+        );
+        this.checkUpstashHost(this._client.options.redisOptions?.host || hosts);
+      } else {
+        this.opts = this._client.options;
+
+        this.checkUpstashHost(this.opts.host);
+      }
 
       this.checkBlockingOptions(deprecationMessage, this.opts);
     }
 
-    this.checkUpstashHost(this.opts.host);
-
     this.handleClientError = (err: Error): void => {
       this.emit('error', err);
     };
@@ -83,8 +91,11 @@ export class RedisConnection extends EventEmitter {
     }
   }
 
-  private checkUpstashHost(host: string | undefined) {
-    if (host?.endsWith('upstash.io')) {
+  private checkUpstashHost(host: string[] | string | undefined) {
+    const includesUpstash = Array.isArray(host)
+      ? host.some(node => node.endsWith('upstash.io'))
+      : host?.endsWith('upstash.io');
+    if (includesUpstash) {
       throw new Error(upstashMessage);
     }
   }
diff --git a/tests/test_connection.ts b/tests/test_connection.ts
index 2e3653885e..a449784164 100644
--- a/tests/test_connection.ts
+++ b/tests/test_connection.ts
@@ -62,6 +62,43 @@ describe('connection', () => {
         'BullMQ: Upstash is not compatible with BullMQ.',
       );
     });
+
+    describe('when using Cluster instance', async () => {
+      it('throws an error', async () => {
+        const connection = new IORedis.Cluster([
+          {
+            host: 'https://upstash.io',
+          },
+        ]);
+
+        expect(() => new QueueBase(queueName, { connection })).to.throw(
+          'BullMQ: Upstash is not compatible with BullMQ.',
+        );
+        await connection.disconnect();
+      });
+    });
+
+    describe('when using redisOptions', async () => {
+      it('throws an error', async () => {
+        const connection = new IORedis.Cluster(
+          [
+            {
+              host: 'localhost',
+            },
+          ],
+          {
+            redisOptions: {
+              host: 'https://upstash.io',
+            },
+          },
+        );
+
+        expect(() => new QueueBase(queueName, { connection })).to.throw(
+          'BullMQ: Upstash is not compatible with BullMQ.',
+        );
+        await connection.disconnect();
+      });
+    });
   });
 
   it('should recover from a connection loss', async () => {
diff --git a/tests/test_obliterate.ts b/tests/test_obliterate.ts
index e70195b0cb..de7e2d18b3 100644
--- a/tests/test_obliterate.ts
+++ b/tests/test_obliterate.ts
@@ -383,6 +383,7 @@ describe('Obliterate', function () {
     const worker = new Worker(
       queue.name,
       async job => {
+        await delay(100);
         return job.log('Lorem Ipsum Dolor Sit Amet');
       },
       { connection },
diff --git a/yarn.lock b/yarn.lock
index f982c8c0c2..8f005c65c9 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -3436,7 +3436,7 @@ into-stream@^6.0.0:
     from2 "^2.3.0"
     p-is-promise "^3.0.0"
 
-ioredis@^4.28.2:
+ioredis@^4.28.5:
   version "4.28.5"
   resolved "https://registry.yarnpkg.com/ioredis/-/ioredis-4.28.5.tgz#5c149e6a8d76a7f8fa8a504ffc85b7d5b6797f9f"
   integrity sha512-3GYo0GJtLqgNXj4YhrisLaNNvWSNwSS2wS4OELGfGxH8I69+XfNdnmV1AyN+ZqMh0i7eX+SWjrwFKDBDgfBC1A==