diff --git a/CHANGELOG.md b/CHANGELOG.md
index 017ec2e415..c4a5fae76b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,7 @@ We use *breaking* word for marking changes that are not backward compatible (rel
 - [#2254](https://github.com/thanos-io/thanos/pull/2254) Bucket: Fix metrics registered multiple times in bucket replicate
 - [#2271](https://github.com/thanos-io/thanos/pull/2271) Bucket Web: Fixed Issue #2260 bucket passes null when storage is empty
 - [#2339](https://github.com/thanos-io/thanos/pull/2339) Query: fix a bug where `--store.unhealthy-timeout` was never respected
+- [#2411](https://github.com/thanos-io/thanos/pull/2411) Query: fix a bug where queries might not time out sometimes due to issues with one or more StoreAPIs
 
 ### Added
 
diff --git a/pkg/store/proxy.go b/pkg/store/proxy.go
index 8440de2f96..c071848c05 100644
--- a/pkg/store/proxy.go
+++ b/pkg/store/proxy.go
@@ -434,7 +434,12 @@ func startStreamSeriesSet(
 				s.warnCh.send(storepb.NewWarnSeriesResponse(errors.New(w)))
 				continue
 			}
-			s.recvCh <- rr.r.GetSeries()
+			select {
+			case s.recvCh <- rr.r.GetSeries():
+			case <-ctx.Done():
+				s.handleErr(errors.Wrapf(ctx.Err(), "failed to receive any data from %s", s.name), done)
+				return
+			}
 		}
 	}()
 	return s
diff --git a/pkg/store/proxy_test.go b/pkg/store/proxy_test.go
index 1e49cce456..8e8b6022d4 100644
--- a/pkg/store/proxy_test.go
+++ b/pkg/store/proxy_test.go
@@ -462,6 +462,60 @@ func TestProxyStore_SeriesSlowStores(t *testing.T) {
 		expectedErr         error
 		expectedWarningsLen int
 	}{
+		{
+			title: "partial response disabled; 1st errors out after some delay; 2nd store is fast",
+			storeAPIs: []Client{
+				&testClient{
+					StoreClient: &mockedStoreAPI{
+						RespSeries: []*storepb.SeriesResponse{
+							storepb.NewWarnSeriesResponse(errors.New("warning")),
+							storeSeriesResponse(t, labels.FromStrings("a", "b"), []sample{{1, 1}, {2, 2}, {3, 3}}),
+						},
+						RespDuration:       2 * time.Second,
+						SlowSeriesIndex:    1,
+						injectedError:      errors.New("test"),
+						injectedErrorIndex: 1,
+					},
+					labelSets: []storepb.LabelSet{{Labels: []storepb.Label{{Name: "ext", Value: "1"}}}},
+					minTime:   1,
+					maxTime:   300,
+				},
+				&testClient{
+					StoreClient: &mockedStoreAPI{
+						RespSeries: []*storepb.SeriesResponse{
+							storepb.NewWarnSeriesResponse(errors.New("warning")),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+							storeSeriesResponse(t, labels.FromStrings("b", "a"), []sample{{4, 1}, {5, 2}, {6, 3}}),
+						},
+					},
+					labelSets: []storepb.LabelSet{{Labels: []storepb.Label{{Name: "ext", Value: "1"}}}},
+					minTime:   1,
+					maxTime:   300,
+				},
+			},
+			req: &storepb.SeriesRequest{
+				MinTime:                 1,
+				MaxTime:                 300,
+				Matchers:                []storepb.LabelMatcher{{Name: "ext", Value: "1", Type: storepb.LabelMatcher_EQ}},
+				PartialResponseDisabled: true,
+			},
+			expectedErr: errors.New("test: receive series from test: test"),
+		},
 		{
 			title: "partial response disabled; 1st store is slow, 2nd store is fast;",
 			storeAPIs: []Client{
@@ -1349,6 +1403,10 @@ type mockedStoreAPI struct {
 	LastSeriesReq      *storepb.SeriesRequest
 	LastLabelValuesReq *storepb.LabelValuesRequest
 	LastLabelNamesReq  *storepb.LabelNamesRequest
+
+	// injectedError will be injected into Recv() if not nil.
+	injectedError      error
+	injectedErrorIndex int
 }
 
 func (s *mockedStoreAPI) Info(ctx context.Context, req *storepb.InfoRequest, _ ...grpc.CallOption) (*storepb.InfoResponse, error) {
@@ -1358,7 +1416,7 @@ func (s *mockedStoreAPI) Info(ctx context.Context, req *storepb.InfoRequest, _ .
 func (s *mockedStoreAPI) Series(ctx context.Context, req *storepb.SeriesRequest, _ ...grpc.CallOption) (storepb.Store_SeriesClient, error) {
 	s.LastSeriesReq = req
 
-	return &StoreSeriesClient{ctx: ctx, respSet: s.RespSeries, respDur: s.RespDuration, slowSeriesIndex: s.SlowSeriesIndex}, s.RespError
+	return &StoreSeriesClient{injectedErrorIndex: s.injectedErrorIndex, injectedError: s.injectedError, ctx: ctx, respSet: s.RespSeries, respDur: s.RespDuration, slowSeriesIndex: s.SlowSeriesIndex}, s.RespError
 }
 
 func (s *mockedStoreAPI) LabelNames(ctx context.Context, req *storepb.LabelNamesRequest, _ ...grpc.CallOption) (*storepb.LabelNamesResponse, error) {
@@ -1382,12 +1440,18 @@ type StoreSeriesClient struct {
 	respSet         []*storepb.SeriesResponse
 	respDur         time.Duration
 	slowSeriesIndex int
+
+	injectedError      error
+	injectedErrorIndex int
 }
 
 func (c *StoreSeriesClient) Recv() (*storepb.SeriesResponse, error) {
 	if c.respDur != 0 && (c.slowSeriesIndex == c.i || c.slowSeriesIndex == 0) {
 		time.Sleep(c.respDur)
 	}
+	if c.injectedError != nil && (c.injectedErrorIndex == c.i || c.injectedErrorIndex == 0) {
+		return nil, c.injectedError
+	}
 
 	if c.i >= len(c.respSet) {
 		return nil, io.EOF