diff --git a/.gitignore b/.gitignore
index 8294f8c1..c6b2ccdd 100644
--- a/.gitignore
+++ b/.gitignore
@@ -8,3 +8,4 @@ tusd_*_*
 __pycache__/
 examples/hooks/plugin/hook_handler
 .idea/
+.vscode/
\ No newline at end of file
diff --git a/cmd/tusd/cli/flags.go b/cmd/tusd/cli/flags.go
index 33e00db5..f77638d4 100644
--- a/cmd/tusd/cli/flags.go
+++ b/cmd/tusd/cli/flags.go
@@ -15,6 +15,7 @@ var Flags struct {
 	HttpHost                         string
 	HttpPort                         string
 	HttpSock                         string
+	EnableH2C                        bool
 	MaxSize                          int64
 	UploadDir                        string
 	Basepath                         string
@@ -87,6 +88,7 @@ func ParseFlags() {
 		f.StringVar(&Flags.HttpSock, "unix-sock", "", "If set, will listen to a UNIX socket at this location instead of a TCP socket")
 		f.StringVar(&Flags.Basepath, "base-path", "/files/", "Basepath of the HTTP server")
 		f.BoolVar(&Flags.BehindProxy, "behind-proxy", false, "Respect X-Forwarded-* and similar headers which may be set by proxies")
+		f.BoolVar(&Flags.EnableH2C, "enable-h2c", false, "Allow for HTTP/2 cleartext (h2c) connections (non-encrypted)")
 	})
 
 	fs.AddGroup("TLS options", func(f *flag.FlagSet) {
diff --git a/cmd/tusd/cli/serve.go b/cmd/tusd/cli/serve.go
index 0ea987e1..a647888d 100644
--- a/cmd/tusd/cli/serve.go
+++ b/cmd/tusd/cli/serve.go
@@ -15,6 +15,9 @@ import (
 	tushandler "github.com/tus/tusd/v2/pkg/handler"
 	"github.com/tus/tusd/v2/pkg/hooks"
 	"github.com/tus/tusd/v2/pkg/hooks/plugin"
+
+	"golang.org/x/net/http2"
+	"golang.org/x/net/http2/h2c"
 )
 
 const (
@@ -160,6 +163,13 @@ func Serve() {
 
 	if protocol == "http" {
 		// Non-TLS mode
+		if Flags.EnableH2C {
+			// Wrap in h2c for optional HTTP/2 support in clear text mode (without TLS)
+			// See https://pkg.go.dev/golang.org/x/net/http2/h2c#NewHandler
+			h2s := &http2.Server{}
+			newHandler := h2c.NewHandler(mux, h2s)
+			server.Handler = newHandler
+		}
 		err = server.Serve(listener)
 	} else {
 		// TLS mode
diff --git a/docs/_getting-started/configuration.md b/docs/_getting-started/configuration.md
index f1b8033e..bb76150f 100644
--- a/docs/_getting-started/configuration.md
+++ b/docs/_getting-started/configuration.md
@@ -22,7 +22,7 @@ By default, tusd listens on port 8080 and all available interfaces. This can be
 $ tusd -host 127.0.0.1 -port 1337
 ```
 
-Once running, tusd accepts HTTP/1.1 requests on the configured port. If [HTTPS/TLS](#httpstls) is configured, tusd will also accept HTTP/2 connection, thanks to [Go's transparent support](https://pkg.go.dev/net/http#hdr-HTTP_2). HTTP/3 and QUIC is currently not supported by tusd directly and requires the use of a reverse proxy.
+Once running, tusd accepts HTTP requests on the configured port.
 
 ### UNIX socket
 
@@ -126,6 +126,14 @@ Alternatively, you can completely disable any CORS-related logic in tusd and han
 $ tusd -disable-cors
 ```
 
+## HTTP/2
+
+By default, tusd only accepts HTTP/1.1 requests on the configured port.
+
+If [HTTPS/TLS](#httpstls) is configured, tusd will also accept an encrypted HTTP/2 connection without any additional configuration, thanks to [Go's transparent support](https://pkg.go.dev/net/http#hdr-HTTP_2).
+
+Alternatively, if HTTPS/TLS is not enabled, support for HTTP/2 cleartext mode (h2c) can be activated using the `-enable-h2c` flag, where tusd also accepts unencrypted HTTP/2 requests. This is useful if a reverse proxy should connect to tusd over HTTP/2 (e.g. in GCP Cloud Run). Be aware that the first request on an upgraded connection (without prior knowledge) is [read fully into memory](https://pkg.go.dev/golang.org/x/net/http2/h2c#NewHandler). To avoid excessive memory usage from PATCH requests, it's recommended to only connect with prior knowledge about tusd's HTTP/2 support.
+
 ## HTTPS/TLS
 
 If you want tusd to be accessible via HTTPS, there are two options:
diff --git a/go.mod b/go.mod
index e79bf401..0a6a8597 100644
--- a/go.mod
+++ b/go.mod
@@ -28,6 +28,7 @@ require (
 	github.com/tus/lockfile v1.2.0
 	github.com/vimeo/go-util v1.4.1
 	golang.org/x/exp v0.0.0-20230626212559-97b1e661b5df
+	golang.org/x/net v0.26.0
 	google.golang.org/api v0.195.0
 	google.golang.org/grpc v1.65.0
 	google.golang.org/protobuf v1.34.2