diff --git a/.github/workflows/pypi.yaml b/.github/workflows/pypi.yaml
new file mode 100644
index 0000000..67c2c89
--- /dev/null
+++ b/.github/workflows/pypi.yaml
@@ -0,0 +1,27 @@
+name: PyPI
+on:
+  push:
+    tags:
+      - v*
+jobs:
+  build-and-publish:
+    name: Build and publish Python package
+    runs-on: ubuntu-latest
+    environment:
+      name: pypi
+      url: https://pypi.org/p/points2regions
+    permissions:
+      id-token: write
+    steps:
+    - name: Checkout
+      uses: actions/checkout@v4
+    - name: Setup Python
+      uses: actions/setup-python@v4
+      with:
+        python-version: "3.x"
+    - name: Install pypa/build
+      run: python3 -m pip install --user build
+    - name: Build wheel & tarball
+      run: python3 -m build
+    - name: Publish package
+      uses: pypa/gh-action-pypi-publish@release/v1
diff --git a/README.md b/README.md
index 163ef97..e5fa429 100644
--- a/README.md
+++ b/README.md
@@ -7,7 +7,7 @@ Points2Regions is a Python tool designed for clustering and defining regions bas
 You can install Points2Regions using the following command:
 
 ```bash
-pip install git+https://github.com/wahlby-lab/Points2Regions
+pip install points2regions
 ```
 
 
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..9bf6df9
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,5 @@
+[build-system]
+requires = ["setuptools>=64", "setuptools_scm>=8"]
+build-backend = "setuptools.build_meta"
+
+[tool.setuptools_scm]
diff --git a/setup.cfg b/setup.cfg
new file mode 100644
index 0000000..5f728b8
--- /dev/null
+++ b/setup.cfg
@@ -0,0 +1,36 @@
+[metadata]
+name = points2regions
+author = Axel Andersson
+author_email = axel.andersson@it.uu.se
+description = A simple and efficient clustering tool for spatial 2D points with categorical labels.
+long_description = file: README.md
+long_description_content_type = text/markdown
+url = https://github.com/wahlby-lab/Points2Regions
+license = MIT
+license_files = LICENSE
+classifiers = 
+    Intended Audience :: Science/Research
+    License :: OSI Approved :: MIT License
+    Operating System :: OS Independent
+    Programming Language :: Python :: 3
+    Programming Language :: Python :: 3 :: Only
+    Programming Language :: Python :: 3.8
+    Programming Language :: Python :: 3.9
+    Programming Language :: Python :: 3.10
+    Programming Language :: Python :: 3.11
+    Programming Language :: Python :: 3.12
+    Topic :: Scientific/Engineering :: Bio-Informatics
+    Topic :: Scientific/Engineering :: Image Processing
+
+[options]
+packages = find:
+python_requires = >=3.8
+install_requires =
+    numpy
+    pandas
+    scikit-image
+    scikit-learn
+    scipy
+
+[options.packages.find]
+include = tissuumaps
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 93175b2..0000000
--- a/setup.py
+++ /dev/null
@@ -1,28 +0,0 @@
-from setuptools import setup, find_packages
-
-setup(
-    name='Points2Regions',
-    version='0.1.0',
-    packages=find_packages(exclude=["tests*", "example*", "tissuumaps"]),
-    description='A simple and efficient clustering tool for spatial 2D points with categorical labels.',
-    long_description=open('README.md').read(),
-    long_description_content_type='text/markdown',
-    author='Axel Andersson',
-    author_email='axel.andersson@it.uu.se',
-    url='https://github.com/wahlby-lab/Points2Regions',
-    install_requires=[
-        'numpy',
-        'scipy',
-        'pandas',
-        'scikit-learn',
-        'scikit-image'
-    ],
-    classifiers=[
-        # Classifiers help users find your project,
-        # see: https://pypi.org/classifiers/
-        'Programming Language :: Python :: 3',
-        'License :: OSI Approved :: MIT License',
-        'Operating System :: OS Independent',
-    ],
-    python_requires='>=3.8',
-)