diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7312641c81a..70bc76b8e03 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -666,7 +666,8 @@ Released with 1.0.0-beta.37 code base.
 ### Fixed
 
   - Improved the error propagation in `web3-providers-http` package to effectively propagate useful error infomation about failed HTTP connections (#5955)
-  - Fix error: "n.data.substring is not a function", that is raised when there is a revert and `web.eth.handleRevert = true` (#6000)
+  - Fixed "Uncaught TypeError" calling a contract function that revert using MetaMask (#4454) and related "n.data.substring is not a function", that is raised when there is a revert and `web.eth.handleRevert = true` (#6000)
+
 ### Changed
 
   - `transaction.type` is now formatted to a hex string before being send to provider (#5979)
diff --git a/packages/web3-core-method/src/index.js b/packages/web3-core-method/src/index.js
index 7747460b2cf..54ff4b7128d 100644
--- a/packages/web3-core-method/src/index.js
+++ b/packages/web3-core-method/src/index.js
@@ -653,7 +653,15 @@ Method.prototype.buildCall = function () {
                 if (!err && method.isRevertReasonString(result)){
                     reasonData = result.substring(10);
                 } else if (err && err.data){
-                    reasonData = (err.data.data || err.data).substring(10);
+                    // workaround embedded error details got from some providers like MetaMask
+                    if (typeof err.data === 'object') {
+                        // Ganache has no `originalError` sub-object unlike others
+                        var originalError = err.data.originalError ?? err.data;
+                        reasonData = originalError.data.substring(10);
+                    }
+                    else {
+                        reasonData = err.data.substring(10);
+                    }
                 }
 
                 if (reasonData){
diff --git a/test/eth.call.revert.js b/test/eth.call.revert.js
new file mode 100644
index 00000000000..75bf8eb89c5
--- /dev/null
+++ b/test/eth.call.revert.js
@@ -0,0 +1,98 @@
+var chai = require('chai');
+var assert = chai.assert;
+var FakeIpcProvider = require('./helpers/FakeIpcProvider');
+var Web3 = require('../packages/web3');
+
+describe('call revert', function () {
+    var provider;
+    var web3;
+
+    beforeEach(function () {
+        provider = new FakeIpcProvider();
+        web3 = new Web3(provider);
+        web3.eth.handleRevert = true;
+    });
+
+    it('Errors with revert reason string through MetaMask', async function() {
+        provider.injectRawError({
+          "code": -32603,
+          "message": "execution reverted: DeadlineExpired",
+          "data": {
+            "originalError": {
+              "code": 3,
+              "data": "0x08c379a00000000000000000000000000000000000000000000000000000000000000020000000000000000000000000000000000000000000000000000000000000000f446561646c696e65457870697265640000000000000000000000000000000000",
+              "message": "execution reverted: DeadlineExpired"
+            }
+          }
+        });
+        provider.injectValidation(function (payload) {
+            assert.equal(payload.jsonrpc, '2.0');
+            assert.equal(payload.method, 'eth_call');
+            assert.deepEqual(
+                payload.params,
+                [{
+                    to: '0xa94f5374fce5edbc8e2a8697c15331677e6ebf0b',
+                    data: '0x23455654',
+                    gas: '0xb',
+                    gasPrice: '0xb'
+                }, 'latest']
+            );
+        });
+
+        var options = {
+            to: '0xa94f5374fce5edbc8e2a8697c15331677e6ebf0b',
+            data: '0x23455654',
+            gas: 11,
+            gasPrice: 11
+        };
+
+        try {
+            await web3.eth.call(options, 'latest');
+            assert.fail('call should have failed!');
+        } catch (error) {
+            assert.equal(error.reason, 'DeadlineExpired');
+        }
+    });
+
+    it('Errors with revert reason string from Ganache through MetaMask', async function() {
+        provider.injectRawError({
+            "code": -32603,
+            "message": "Internal JSON-RPC error.",
+            "data": {
+              "message": "VM Exception while processing transaction: revert ImproperState",
+              "stack": "CallError: VM Exception while processing transaction: revert ImproperState\n    at Blockchain.simulateTransaction (C:\\Users\\nicos\\AppData\\Roaming\\npm\\node_modules\\ganache\\dist\\node\\1.js:2:82786)",
+              "code": -32000,
+              "name": "CallError",
+              "data": "0x08c379a00000000000000000000000000000000000000000000000000000000000000020000000000000000000000000000000000000000000000000000000000000000d496d70726f706572537461746500000000000000000000000000000000000000"
+            }
+        });
+        provider.injectValidation(function (payload) {
+            assert.equal(payload.jsonrpc, '2.0');
+            assert.equal(payload.method, 'eth_call');
+            assert.deepEqual(
+                payload.params,
+                [{
+                    to: '0xa94f5374fce5edbc8e2a8697c15331677e6ebf0b',
+                    data: '0x23455654',
+                    gas: '0xb',
+                    gasPrice: '0xb'
+                }, 'latest']
+            );
+        });
+
+        var options = {
+            to: '0xa94f5374fce5edbc8e2a8697c15331677e6ebf0b',
+            data: '0x23455654',
+            gas: 11,
+            gasPrice: 11
+        };
+
+        try {
+            await web3.eth.call(options, 'latest');
+            assert.fail('call should have failed!');
+        } catch (error) {
+            assert.equal(error.reason, 'ImproperState');
+        }
+    });
+    
+});
diff --git a/test/helpers/FakeIpcProvider.js b/test/helpers/FakeIpcProvider.js
index 6f52cb6c667..c877027127a 100644
--- a/test/helpers/FakeIpcProvider.js
+++ b/test/helpers/FakeIpcProvider.js
@@ -142,6 +142,11 @@ FakeIpcProvider.prototype.injectError = function (error) {
     this.error.push(errorStub);
 };
 
+// to simulate strange behavior of MetaMask
+FakeIpcProvider.prototype.injectRawError = function (error) {
+    this.error.push(error);
+};
+
 FakeIpcProvider.prototype.injectValidation = function (callback) {
     this.validation.push(callback);
 };