diff --git a/docs/config.rst b/docs/config.rst
index a8da73db..d64d2f88 100644
--- a/docs/config.rst
+++ b/docs/config.rst
@@ -339,6 +339,44 @@ Produces these sessions when running ``nox --list``:
     * tests(mysql, new)
 
 
+Parametrizing the session Python
+--------------------------------
+
+You can use parametrization to select the Python interpreter for a session.
+These two examples are equivalent:
+
+.. code-block:: python
+
+    @nox.session
+    @nox.parametrize("python", ["3.6", "3.7", "3.8"])
+    def tests(session):
+        ...
+
+    @nox.session(python=["3.6", "3.7", "3.8"])
+    def tests(session):
+        ...
+
+The first form can be useful if you need to exclude some combinations of Python
+versions with other parameters. For example, you may want to test against
+multiple versions of a dependency, but the latest version doesn't run on older
+Pythons:
+
+.. code-block:: python
+
+    @nox.session
+    @nox.parametrize(
+        "python,dependency",
+        [
+            (python, dependency)
+            for python in ("3.6", "3.7", "3.8")
+            for dependency in ("1.0", "2.0")
+            if (python, dependency) != ("3.6", "2.0")
+        ],
+    )
+    def tests(session, dependency):
+        ...
+
+
 The session object
 ------------------
 
diff --git a/nox/_decorators.py b/nox/_decorators.py
index 03878deb..b04e48ab 100644
--- a/nox/_decorators.py
+++ b/nox/_decorators.py
@@ -1,5 +1,6 @@
 import copy
 import functools
+import inspect
 import types
 from typing import Any, Callable, Dict, Iterable, List, Optional, cast
 
@@ -66,20 +67,35 @@ def copy(self, name: str = None) -> "Func":
 
 class Call(Func):
     def __init__(self, func: Func, param_spec: "Param") -> None:
+        call_spec = param_spec.call_spec
+        session_signature = "({})".format(param_spec)
+
+        # Determine the Python interpreter for the session using either @session
+        # or @parametrize. For backwards compatibility, we only use a "python"
+        # parameter in @parametrize if the session function does not expect it
+        # as a normal argument, and if the @session decorator does not already
+        # specify `python`.
+
+        python = func.python
+        if python is None and "python" in call_spec:
+            signature = inspect.signature(func.func)
+            if "python" not in signature.parameters:
+                python = call_spec.pop("python")
+
         super().__init__(
             func,
-            func.python,
+            python,
             func.reuse_venv,
             None,
             func.venv_backend,
             func.venv_params,
             func.should_warn,
         )
-        self.param_spec = param_spec
-        self.session_signature = "({})".format(param_spec)
+        self.call_spec = call_spec
+        self.session_signature = session_signature
 
     def __call__(self, *args: Any, **kwargs: Any) -> Any:
-        kwargs.update(self.param_spec.call_spec)
+        kwargs.update(self.call_spec)
         return super().__call__(*args, **kwargs)
 
     @classmethod
diff --git a/tests/test__parametrize.py b/tests/test__parametrize.py
index d130174a..79fc2e5d 100644
--- a/tests/test__parametrize.py
+++ b/tests/test__parametrize.py
@@ -15,7 +15,7 @@
 from unittest import mock
 
 import pytest
-from nox import _decorators, _parametrize
+from nox import _decorators, _parametrize, parametrize, session
 
 
 @pytest.mark.parametrize(
@@ -242,3 +242,69 @@ def test_generate_calls_ids():
     f.assert_called_with(foo=1)
     calls[1]()
     f.assert_called_with(foo=2)
+
+
+def test_generate_calls_session_python():
+    called_with = []
+
+    @session
+    @parametrize("python,dependency", [("3.8", "0.9"), ("3.9", "0.9"), ("3.9", "1.0")])
+    def f(session, dependency):
+        called_with.append((session, dependency))
+
+    calls = _decorators.Call.generate_calls(f, f.parametrize)
+
+    assert len(calls) == 3
+
+    assert calls[0].python == "3.8"
+    assert calls[1].python == "3.9"
+    assert calls[2].python == "3.9"
+
+    assert calls[0].session_signature == "(python='3.8', dependency='0.9')"
+    assert calls[1].session_signature == "(python='3.9', dependency='0.9')"
+    assert calls[2].session_signature == "(python='3.9', dependency='1.0')"
+
+    session_ = ()
+
+    calls[0](session_)
+    calls[1](session_)
+    calls[2](session_)
+
+    assert len(called_with) == 3
+
+    assert called_with[0] == (session_, "0.9")
+    assert called_with[1] == (session_, "0.9")
+    assert called_with[2] == (session_, "1.0")
+
+
+def test_generate_calls_python_compatibility():
+    called_with = []
+
+    @session
+    @parametrize("python,dependency", [("3.8", "0.9"), ("3.9", "0.9"), ("3.9", "1.0")])
+    def f(session, python, dependency):
+        called_with.append((session, python, dependency))
+
+    calls = _decorators.Call.generate_calls(f, f.parametrize)
+
+    assert len(calls) == 3
+
+    assert calls[0].python is None
+    assert calls[1].python is None
+    assert calls[2].python is None
+
+    assert calls[0].session_signature == "(python='3.8', dependency='0.9')"
+    assert calls[1].session_signature == "(python='3.9', dependency='0.9')"
+    assert calls[2].session_signature == "(python='3.9', dependency='1.0')"
+
+    session_ = ()
+
+    calls[0](session_)
+    calls[1](session_)
+    calls[2](session_)
+
+    assert len(called_with) == 3
+
+    assert called_with[0] == (session_, "3.8", "0.9")
+    assert called_with[1] == (session_, "3.9", "0.9")
+    assert called_with[2] == (session_, "3.9", "1.0")