The Bacterial and Viral Bioinformatics Resource Center (BV-BRC) is an information system designed to support the biomedical research community’s work on bacterial and viral infectious diseases via integration of vital pathogen information with rich data and analysis tools. BV-BRC combines the data, technology, and extensive user communities from two long-running centers: PATRIC, the bacterial system , and IRD/ViPR, the viral systems. In addition to hundreds of thousands of bacterial genomes in PATRIC and over a million viral genomes in IRD/ViPR, the two resources host data on protein structure and function, clinical studies, drug targets and resistance, epidemiology, and other features, and provide open source tools for data analysis and genomic annotation.