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add tiger project
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martvanrijthoven committed Feb 8, 2023
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40 changes: 40 additions & 0 deletions content/pages/projects/tiger.md
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title: TIGER Challenge
finished: true
type: general
picture: projects/tiger-banner.png
template: project-single
groups: pathology
default_group: pathology
description: Challenge on tumor infiltrating lymphcytes
people: Mart van Rijthoven, Witali Aswolinskiy, Leslie Tessier, Joep Bogaerts, Maschenka Balkenhol, James Meakin, Bram van Ginneken, Francesco Ciompi, Jeroen van der Laak
bibkeys:


<img alt="TIGER Challenge logo" class="img-fluid" src="https://rumc-gcorg-p-public.s3.amazonaws.com/b/636/tiger-banner_z2IclkS.x20.jpeg">


TIGER is the first challenge on fully automated assessment of tumor-infiltrating lymphocytes (TILs) in H&E breast cancer slides. The goal of this challenge is to evaluate new computer algorithms for the automated assessment of tumor-infiltrating lymphocytes (TILs) in Her2 positive and Triple Negative breast cancer (BC) histopathology slides. In recent years, several studies have shown the predictive and prognostic value of visually scored TILs in BC as well as in other cancer types, making TILs a powerful biomarker that can potentially be used in the clinic. With TIGER, we aim at developing computer algorithms that can automatically generate a "TIL score" with a high prognostic value.

## Tasks

Participants in the TIGER challenge will have to develop computer algorithms to analyze H&E-stained whole-slide images of breast cancer histopathology, to perform three tasks:

- detection of lymphocytes and plasma cells, which are the main types of cells considered as tumor-infiltrating lymphocytes;
- segmentation of invasive tumor and tumor-associated stroma, which are the main tissue compartments considered when identifying relevant regions for the TILs;
- compute an automated TILs score, one score per slide, based on the output of detection and segmentation.

## Participate in the challenge

The challenge is hosted on [Grand-Challenge](https://grand-challenge.org/). Please signup at the [TIGER Challenge](https://tiger.grand-challenge.org/).

## Supporters

The TIGER challenge is supported by

- [International Immuno-Oncology Biomarker Working Group on Breast Cancer](https://tilsinbreastcancer.org)
- [AWS](https://aws.amazon.com/)
- [Jules Bordet Institute](https://www.bordet.be/)
- [Breast Cancer Research Foundation](https://www.bcrf.org/)
- [NuCLS](https://nucls.grand-challenge.org/)
- [ExaMode](https://www.examode.eu/)

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