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| digraph { | ||
| node [shape="box" margin=0.05 width=0 height=0]; | ||
| //ratio="compress" | ||
| //rank="same" | ||
| rankdir="LR" | ||
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| graph[size="7.75,10.25"] | ||
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| margin=0; | ||
| graph [fontsize=8]; | ||
| //edge [fontsize=8]; | ||
| node [fontsize=8]; | ||
|
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| "Fertilized egg" [style="filled,dashed" fillcolor="lightgrey"] | ||
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| "Fertilized egg" -> "Trophoblast" | ||
| "Trophoblast" -> "Placental cell" | ||
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| "Fertilized egg" -> "Epiblast" | ||
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| "Epiblast" -> "Embryonic stem cell" | ||
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| "Embryonic stem cell" -> "Primordial germ cell" | ||
| "Primordial germ cell" -> "Pre-Sertoli cell" | ||
| "Pre-Sertoli cell" -> "Sertoli cell" | ||
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| "Primordial germ cell" -> "Pre-Leydig cell" | ||
| "Pre-Leydig cell" -> "Leydig cell" | ||
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| "Primordial germ cell" -> "Theca cell" | ||
| "Theca cell" -> "Small Luteal cell" | ||
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| "Primordial germ cell" -> "Pre-Granulosa cell" | ||
| "Pre-Granulosa cell" -> "Granulosa cell" | ||
| "Granulosa cell" -> "Cumulus cell" | ||
| "Granulosa cell" -> "Mature Granulosa cell" | ||
| "Granulosa cell" -> "Mural Granulosa cell" | ||
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| "Primordial germ cell" -> "Ovarian Somatic cell" | ||
| "Primordial germ cell" -> "Testis Somatic cell" | ||
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| "Embryonic stem cell" -> "Ectoderm" | ||
| "Embryonic stem cell" -> "Mesoderm" | ||
| "Embryonic stem cell" -> "Endoderm" | ||
|
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| subgraph { | ||
| node[fillcolor="#e6fffa" style="filled,solid"] | ||
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| "Mesoderm" -> "Hemangioblast" -> "Hematopoietic stem cell" | ||
| "Hematopoietic stem cell" -> "Myeloid progenitor" | ||
| "Hematopoietic stem cell" -> "Lymphoid progenitor" | ||
| "Myeloid progenitor" -> "Myeloblast" | ||
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| "Myeloblast" -> "Basophil" | ||
| "Myeloblast" -> "Neutrophil" | ||
| "Myeloblast" -> "Eosinophil" | ||
| "Myeloblast" -> "Monocyte" | ||
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| "Lymphoid progenitor" -> "NK cell" | ||
| "Lymphoid progenitor" -> "Small lymphocyte" | ||
| "Small lymphocyte" -> "Naive T cell" | ||
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| "Naive T cell" -> "T Helper cell" | ||
| "Naive T cell" -> "T Cytotoxic cell" | ||
| "Naive T cell" -> "T Memory cell" | ||
| "Naive T cell" -> "T Regulatory cell" | ||
| "Naive T cell" -> "NKT cell" | ||
| "Naive T cell" -> "Gamma delta T cell" | ||
| "Naive T cell" -> "MAIT cell" | ||
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| "Small lymphocyte" -> "Immature B cell" | ||
| "Immature B cell" -> "B cell" | ||
| "B cell" -> "Memory B cell" | ||
| "Memory B cell" -> "Plasma cell" | ||
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| "Monocyte" -> "Fetal macrophage" -> "Mature macrophage" -> "Kupffer cell" | ||
| "Fetal macrophage" -> "Red pulp macrophage" | ||
| "Monocyte" -> "Microglia cell" | ||
| "Monocyte" -> "Conventional dendritic cell\n(syn. Myeloid dendritic cell)" | ||
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| "Conventional dendritic cell\n(syn. Myeloid dendritic cell)" -> "Langerhans cell" | ||
| "Conventional dendritic cell\n(syn. Myeloid dendritic cell)" -> "Adipose dendritic cell" | ||
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| "Myeloid progenitor" -> "Megakaryoblast" -> "Megakaryocyte" -> "Platelets" | ||
| "Myeloid progenitor" -> "Erythroblast" -> "Reticulocyte" -> "Erythrocyte" | ||
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| "Myeloid progenitor" -> "Plasmacytoid dendritic cell" | ||
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| "Erythrocyte" -> "Nucleate erythrocyte" | ||
| "Erythrocyte" -> "Anucleate erythrocyte" | ||
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| "Myeloid progenitor" -> "Mast cell" | ||
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| "Mesoderm" -> "Cardiac mesoderm" -> "Cardiomyocyte" | ||
| "Cardiac mesoderm" -> "Conduction cell (His bundle, AV nodal)" | ||
| "Cardiac mesoderm" -> "Endothelial cell" | ||
| "Cardiac mesoderm" -> "Fibroblast" | ||
| "Cardiac mesoderm" -> "Vascular smooth muscle cell" | ||
| } | ||
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| "Hemangioblast" -> "Angioblast" | ||
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| // Mesenchymal stem cell | ||
| subgraph { | ||
| node[fillcolor="#f5d6eb" style="filled,solid"] | ||
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| "Mesoderm" -> "Mesenchymal stem cell" | ||
| "Mesenchymal stem cell" -> "Osteoblast" -> "Osteocyte" | ||
| "Mesenchymal stem cell" -> "Pre-osteoclast" -> "Osteoclast" | ||
| "Mesenchymal stem cell" -> "Pre-myoblast progenitor cell" | ||
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| "Pre-myoblast progenitor cell" -> "Satellite cell" | ||
| "Pre-myoblast progenitor cell" -> "Myoblast" | ||
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| "Myoblast" -> "Skeletal muscle cell" | ||
| "Myoblast" -> "Cardiac muscle cell" | ||
| "Myoblast" -> "Smooth muscle cell" | ||
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| "Mesenchymal stem cell" -> "Stromal cell" | ||
| "Mesenchymal stem cell" -> "Common fibroblast progenitor" -> "Fibroblast" | ||
| "Mesenchymal stem cell" -> "Periosteal cell" -> "Chondroprogenitor" -> "Chondrocyte" -> "Hypertrophic chondrocyte" | ||
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| "Periosteal cell" -> "Tendon cell" | ||
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| "Mesenchymal stem cell" -> "White pre-adipocyte" -> "White adipocyte" | ||
| "Mesenchymal stem cell" -> "Brown pre-adipocyte" -> "Brown adipocyte" | ||
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| "Mesenchymal stem cell" -> "Vascular progenitor cell" | ||
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| "Vascular progenitor cell" -> "Angioblast" -> "Endothelial cell" | ||
| "Endothelial cell" -> "Arterial endothelial cell" | ||
| "Endothelial cell" -> "Venous endothelial cell" -> "Lymphatic endothelial cell" | ||
| "Vascular progenitor cell" -> "Pericyte" | ||
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| // kidney | ||
| "Mesenchymal stem cell" -> "Metanephric progenitor cell" | ||
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| subgraph cluster3 { | ||
| color=lightgrey; | ||
| label="Kidney"; | ||
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| "Metanephric progenitor cell" -> "Loop of Hendle cell" | ||
| "Metanephric progenitor cell" -> "Proximal tubule cell" | ||
| "Metanephric progenitor cell" -> "Distal tubule cell" | ||
| "Metanephric progenitor cell" -> "Podocyte" | ||
| "Metanephric progenitor cell" -> "Juxtaglomerular cell" | ||
| "Metanephric progenitor cell" -> "Mesangial cell" | ||
| "Metanephric progenitor cell" -> "Vascular smooth muscle cell" | ||
| "Metanephric progenitor cell" -> "Macula densa cell" [color=grey] | ||
| "Metanephric progenitor cell" -> "Principal cells" | ||
| "Metanephric progenitor cell" -> "Intercalated cells" | ||
| } | ||
| } | ||
|
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||
| // Neuronal | ||
| subgraph { | ||
| node[fillcolor="#f2ffe6" style="filled,solid"] | ||
|
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| "Ectoderm" -> "Neuronal stem cell" | ||
| "Neuronal stem cell" -> "Neuronal progenitor cell" | ||
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| "Neuronal progenitor cell" -> "Neuron-restricted progenitor" | ||
| "Neuron-restricted progenitor" -> "Purkinje neuron" | ||
| "Neuron-restricted progenitor" -> "Dopaminergic neuron" | ||
| "Neuron-restricted progenitor" -> "GABAergic neuron" | ||
| "Neuron-restricted progenitor" -> "Peptidergic neuron" | ||
| "Neuron-restricted progenitor" -> "Noradrenergic neuron" | ||
| "Neuron-restricted progenitor" -> "Nitrergic neuron" | ||
| "Neuron-restricted progenitor" -> "Mauthner neuron" | ||
| "Neuron-restricted progenitor" -> "hypocretin-secreting neuron" | ||
| "Neuron-restricted progenitor" -> "Histaminergic neuron" | ||
| "Neuron-restricted progenitor" -> "Glycinergic neuron" | ||
| "Neuron-restricted progenitor" -> "Galanergic neuron" | ||
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| "GABAergic neuron" -> "Kolmer-Agduhr neuron" | ||
| "GABAergic neuron" -> "Lugaro cell" | ||
| "GABAergic neuron" -> "cerebellar Golgi cell" | ||
| "GABAergic neuron" -> "GABAergic interplexiform cell" | ||
| "GABAergic neuron" -> "cerebral cortex GABAergic interneuron" | ||
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| "Neuron-restricted progenitor" -> "Sensory neuron" | ||
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| "Sensory neuron" -> "Chemoreceptor cell" | ||
| "Sensory neuron" -> "vomeronasal sensory neuron" | ||
| "Sensory neuron" -> "sensory neuron of spinal nerve" | ||
| "Sensory neuron" -> "sensory neuron of dorsal root ganglion" | ||
| "Sensory neuron" -> "Rohon-Beard neuron" | ||
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| "Sensory neuron" -> "Photoreceptor cell" | ||
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| "Photoreceptor cell" -> "retinal Rod cell" | ||
| "Photoreceptor cell" -> "retinal Cone cell" | ||
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| "Sensory neuron" -> "Olfactory bulb interneuron" | ||
| "Olfactory bulb interneuron" -> "mitral cell" | ||
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| "Chemoreceptor cell" -> "Olfactory receptor cell" | ||
| "Olfactory receptor cell" -> "ciliated olfactory receptor neuron" | ||
| "Olfactory receptor cell" -> "crypt olfactory receptor neuron" | ||
| "Olfactory receptor cell" -> "microvillous olfactory receptor neuron" | ||
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| "Chemoreceptor cell" -> "Taste receptor cell" | ||
| "Taste receptor cell" -> "type I taste bud cell" | ||
| "Taste receptor cell" -> "type II taste bud cell" | ||
| "Taste receptor cell" -> "type III taste bud cell" | ||
| "Taste receptor cell" -> "type IV taste bud cell" | ||
| "Taste receptor cell" -> "type V taste bud cell" | ||
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| "Neuron-restricted progenitor" -> "Cholinergic neuron" | ||
| "Neuron-restricted progenitor" -> "Glutamatergic neuron" | ||
| "Neuron-restricted progenitor" -> "Cajal-Retzius cell" | ||
| "Neuron-restricted progenitor" -> "Pyramidal cell" | ||
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| "Pyramidal cell" -> "Meynert cell" | ||
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| "Neuron-restricted progenitor" -> "Serotonergic neuron" | ||
| "Neuronal progenitor cell" -> "Motor neuron progenitor" -> "Motor neuron" | ||
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| "Neuronal stem cell" -> "Glia progenitor cell" | ||
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| "Glia progenitor cell" -> "Type 1 Astrocyte progenitor cell" -> "Type 1 Astrocyte" | ||
| "Glia progenitor cell" -> "Type 2 Astrocyte progenitor cell" -> "Type 2 Astrocyte" | ||
| "Glia progenitor cell" -> "Oligodendrocyte progenitor cell" -> "Pre-oligodendrocyte" -> "Oligodendrocyte" | ||
|
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| "Glia progenitor cell" -> "Radial progenitor cell" -> "Radial glia cell" | ||
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| "Radial glia cell" -> "Bergmann glia cell" | ||
| "Radial glia cell" -> "Muller glia cell" | ||
| "Radial glia cell" -> "Ependymal cell" -> "Tanycytes" | ||
| "Radial glia cell" -> "Pituicyte" | ||
| } | ||
|
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||
| // Neural crest | ||
| subgraph { | ||
| node[fillcolor="#ccccff" style="filled,solid"] | ||
|
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| "Ectoderm" -> "Neural crest cell" -> "Schwann cell precursor" -> "Immature Schwann cell" | ||
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| "Immature Schwann cell" -> "Myelinating Schwann cell" | ||
| "Immature Schwann cell" -> "Non-myelinating Schwann cell" | ||
|
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| // Anterior pituitary gland cell | ||
| Ectoderm -> "Anterior pituitary gland cell" | ||
|
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| // | ||
| "Neural crest cell" -> "Melanoblast" -> "Melanocyte" | ||
| "Neural crest cell" -> "Cardiac neural crest progenitor" | ||
|
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| "Cardiac neural crest progenitor" -> "Cardiac neuron" | ||
| "Cardiac neural crest progenitor" -> "Cardiac smooth muscle cell" | ||
| } | ||
|
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| // Mammary | ||
| "Mammary stem cell" -> "Myoepithelial cell" | ||
| "Mammary stem cell" -> "Luminal epithelial cell" | ||
|
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| // Endoderm | ||
| subgraph { | ||
| node[fillcolor="#ffff99" style="filled,solid"] | ||
|
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| "Endoderm" -> "Hepatoblast" | ||
| "Hepatoblast" -> "Hepatocyte" | ||
| "Hepatoblast" -> "Cholangiocyte" | ||
| "Hepatoblast" -> "Oval cells" | ||
|
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| "Endoderm" -> "Pancreatic progenitor" | ||
|
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| // weirdness. name must start with "cluster" to get a box. | ||
| subgraph cluster2 { | ||
| color=lightgrey; | ||
| label="Pancreas"; | ||
|
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| "Pancreatic progenitor" -> "Endocrine progenitor" | ||
| "Endocrine progenitor" -> "Alpha cell" | ||
| "Endocrine progenitor" -> "Beta cell" | ||
| "Endocrine progenitor" -> "Delta cell" | ||
| "Endocrine progenitor" -> "Epsilon cell" | ||
| "Endocrine progenitor" -> "Pancreatic polypeptide cell" | ||
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| "Pancreatic progenitor" -> "Exocrine progenitor" | ||
| "Exocrine progenitor" -> "Acinar cell" | ||
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| "Pancreatic progenitor" -> "Ductal cell" | ||
| } | ||
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| "Endoderm" -> "GI Non-secretory progenitor" | ||
| "Endoderm" -> "GI secretory progenitor" | ||
|
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| // weirdness. name must start with "cluster" to get a box. | ||
| subgraph cluster1 { | ||
| color=lightgrey; | ||
| label="GI tract"; | ||
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| "GI Non-secretory progenitor" -> "Enterocyte" | ||
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| "GI secretory progenitor" -> "Paneth cell" | ||
| "GI secretory progenitor" -> "Goblet cell" | ||
| "GI secretory progenitor" -> "Tuft cell" | ||
| "GI secretory progenitor" -> "Enteroendocrine cell" | ||
| } | ||
| } | ||
|
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| "Hepatic stellate cells" -> "Myofibroblasts" | ||
| } |
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